Azelaoyl PAF
Item № 60924
CAS № 354583-69-0
Purity ≥98%
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500 µg $27.00 $0.00
1 mg $51.00 $0.00
5 mg $216.00 $0.00
10 mg $378.00 $0.00

Pricing updated 2015-11-25. Prices are subject to change without notice.

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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.1 One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.2 Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.2

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Technical Information
Formal Name 1-O-hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
CAS Number 354583-69-0
Molecular Formula C33H66NO9P
Formula Weight 651.9
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 82 Kb PDF

Download Safety Data Sheet (SDS) 28 Kb PDF

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References & Background Reading
Product Description References

1. Tontonoz, P., Nagy, L., Alvarez, J.G.A., et al. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 241-252 (1998).

2. Davies, S.S., Pontsler, A.V., Marathe, G.K., et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists. J Biol Chem 276 16015-16023 (2001).

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