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Join us! · ENDO 2015 · San Diego, California · March 5-8, 2015 · Booth 1935
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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2015 Cayman Chemical Company

Azelaoyl PAF

Cayman Chemical Item Number 60924

(CAS 354583-69-0)

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Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.1 One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.2 Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.2

1. Tontonoz, P., Nagy, L., Alvarez, J.G.A., et al. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 241-252 (1998).

2. Davies, S.S., Pontsler, A.V., Marathe, G.K., et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists. J Biol Chem 276 16015-16023 (2001).

Formal Name 1-​O-​hexadecyl-​2-​O-​(9-​carboxyoctanoyl)-​sn-​glyceryl-​3-​phosphocholine
CAS Number 354583-69-0
Molecular Formula C33H66NO9P
Formula Weight 651.9
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(OC(CCCCCCCC(O)​=O)​=O)​COP([O-]​)​(OCC[N+]​(C)​(C)​C)​=O
InCHI Code
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​1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)​41-28-26-34(2,3)​4)​43-33(37)​25-22-19-17-18-21-24-32(35)​36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)​/t31-/m1/s1
InCHI Key
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ZDFOCDTXDPKJKA-WJOKGBTCSA-N

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Azelaoyl PAF is available in the following screening library:

Size Price Quantity Subtotal
500 µg $27.00 $0.00
1 mg $51.00 $0.00
5 mg $216.00 $0.00
10 mg $378.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2015-02-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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