D-myo-Inositol-1,3,4-triphosphate (sodium salt)

Cayman Chemical Item Number 60972

1,3,4-IP3 (sodium salt); Ins(1,3,4)-P3 (sodium salt)

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The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.1,2 D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.3 The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.4 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.5

1. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3. Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem 274 18973-18980 (1999).

4. Lew, P.D., Monod, A., Krause, K., et al. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. J Biol Chem 261 13121-13127 (1986).

5. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

  • 1,3,4-IP3 (sodium salt)
  • Ins(1,3,4)-P3 (sodium salt)
Formal Name D-​myo-​inositol-​1,​3,​4-​tris(dihydrogen phosphate),​ trisodium salt
Molecular Formula C6H12O15P3 · 3Na
Formula Weight 486.0
Formulation A lyophilized powder
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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D-myo-Inositol-1,3,4-triphosphate (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
100 µg $35.00 $0.00
500 µg $158.00 $0.00
1 mg $280.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-05. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA


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