2-Arachidonyl Glycerol ether

Cayman Chemical Item Number 62165

2-AG ether; Noladin (CAS 222723-55-9)

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2-Arachidonyl glycerol ether (2-AG ether) has been isolated from porcine brain and its structure determined by mass spec analysis.1 2-AG ether has also been synthesized as an analog of the endogenous cannabinoid (CB), 2-AG, for structure activity testing.2 2-AG ether is a selective central cannabinoid (CB1) receptor agonist exhibiting Ki values of 21.2 nM and >3 µM at the CB1 and peripheral cannabinoid (CB2) receptors, respectively, and displays the typical tetrad of CB activities in mice.1 It is much more chemically stable than 2-AG, with an endogenous half-life of hours rather than minutes.3 However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.2 2-AG ether elicits modest reductions in IOP in rabbits when administered at doses exceeding 50 µg per eye.3 2-AG ether increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.4

1. Hanus, L., Abu-Lafi, S., Fride, E., et al. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci USA 98 3662-3665 (2001).

2. Sugiura, T., Kodaka, T., Nakane, S., et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem 274 2794-2801 (1999).

3. Laine, K., Jarvinen, K., Mechoulam, R., et al. Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. Invest Ophthamol Vis Sci 43(10) 3216-3222 (2002 Oct 1).

4. Njie, Y.F., Kumar, A., Qiao, Z., et al. Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility. Invest Ophthamol Vis Sci 47(5) 1999-2005 (2006).

  • 2-AG ether
  • Noladin
Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraen-​2-​glyceryl ether
CAS Number 222723-55-9
Molecular Formula C23H40O3
Formula Weight 364.6
Formulation A solution in ethanol
Purity ≥98%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
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2-Arachidonyl Glycerol ether is available in the following screening library:

Size Price Quantity Subtotal
1 mg $20.00 $0.00
5 mg $90.00 $0.00
10 mg $160.00 $0.00
25 mg $350.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

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