Fumonisin B1
Item № 62580
CAS № 116355-83-0
Purity ≥98%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $48.00 $0.00
5 mg $216.00 $0.00
10 mg $384.00 $0.00
25 mg $768.00 $0.00

Pricing updated 2015-09-03. Prices are subject to change without notice.

Bulk Inquiry Form

X

Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Description

Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains. Outbreaks of food poisoning in livestock and humans following the consumption of Fusarium infested corn are caused by fumonisins.1 It functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).2 Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.3 It also blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, again through inhibition of ceramide production.4 Incubation of Swiss 3T3 cells with fumonisin B1 results in both an altered cell morphology due to disruption of axonal growth and a decrease in cell proliferation.5

Download Product Insert Download Safety Data Sheet (SDS)

Related Products

Show all 21 Hide all but first 3

View Related Product Categories
View Screening Libraries with Fumonisin B1
Technical Information
Formal Name 1,​2,​3-​propanetricarboxylic acid,​ 1,​-​1'-​[1-​(12-​amino-​4,​9,​11-​trihydroxy-​2-​methyltridecyl)-​2-​(1-​methylpentyl)-​1,​2-​ethanediyl] ester
CAS Number 116355-83-0
Molecular Formula C34H59NO15
Formula Weight 721.8
Purity ≥98%
Formulation A crystalline solid
SMILES C[C@H]​(N)​[C@@H]​(O)​C[C@H]​(O)​CCCC[C@@H]​(O)​C[C@H]​(C)​CC(OC(C[C@H]​(C(O)​=O)​CC(O)​=O)​=O)​C(OC(C[C@@H]​(C(O)​=O)​CC(O)​=O)​=O)​[C@@H]​(C)​CCCC
InChI Code ​1S/C34H59NO15/c1-5-6-9-20(3)​32(50-31(44)​17-23(34(47)​48)​15-29(41)​42)​27(49-30(43)​16-22(33(45)​46)​14-28(39)​40)​13-19(2)​12-24(36)​10-7-8-11-25(37)​18-26(38)​21(4)​35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)​(H,41,42)​(H,45,46)​(H,47,48)​/t19-,20+,21-,22?,2
InChI Key UVBUBMSSQKOIBE-BQLGDNNVSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
Product Downloads

Download Product Insert 126 Kb PDF

Download Safety Data Sheet (SDS) 27 Kb PDF

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

Inserts
QC Sheets
Certificates of Analysis
GCMS Data
References & Background Reading
Product Description References

1. Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins - novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol 54 1806-1811 (1988).

2. Wang, E., Norred, W.P., Bacon, C.W., et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266 14486-14490 (1991).

3. Balsinde, J., Balboa, M.A., and Dennis, E.A. Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. J Biol Chem 272 20373-20377 (1997).

4. Wieder, T., Orfanos, C.E., and Geilen, C.C. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. J Biol Chem 273 11025-11031 (1998).

5. Meivar-Levy, I., Sbanay, H., Bershadsky, A.D., et al. The role of sphingolipids in the maintenance of fibroblast morphology. The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3. J Biol Chem 272 1558-1564 (1997).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...