7-hydroxycoumarinyl Arachidonate

Cayman Chemical Item Number 62910

Umbelliferyl Arachidonate (CAS 161180-11-6)

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7-hydroxycoumarinyl Arachidonate is the arachidonic acid ester of 7-hydroxycoumarin (umbelliferone) and behaves as a substrate for cPLA2. Hydrolysis of 7-hydroxycoumarinyl arachidonate by phospholipase results in the release of the fluorescent compound 7-hydroxycoumarin which can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm).1,2

1. Huang, Z., Laliberté, F., Tremblay, N.M., et al. A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. Anal Biochem 222 110-115 (1994).

2. Pickard, R.T., Chiou, X.G., Strifler, B.A., et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem 271 19225-19231 (1996).

  • Umbelliferyl Arachidonate
Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenoic acid,​ 2-​oxo-​2H-​1-​benzopyran-​7-​yl ester
CAS Number 161180-11-6
Molecular Formula C29H36O4
Formula Weight 448.6
Formulation A solution in ethanol
Purity ≥98%
λmax 282, 312 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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7-hydroxycoumarinyl Arachidonate is available in the following screening library:

Size Price Quantity Subtotal
5 mg $28.00 $0.00
10 mg $53.00 $0.00
25 mg $126.00 $0.00
50 mg $224.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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