7-hydroxycoumarinyl Arachidonate Exclusive

Cayman Chemical Item Number 62910

Umbelliferyl Arachidonate (CAS 161180-11-6)

7-hydroxycoumarinyl Arachidonate (CAS 161180-11-6)

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Description

7-hydroxycoumarinyl Arachidonate is the arachidonic acid ester of 7-hydroxycoumarin (umbelliferone) and behaves as a substrate for cPLA2. Hydrolysis of 7-hydroxycoumarinyl arachidonate by phospholipase results in the release of the fluorescent compound 7-hydroxycoumarin which can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm).1,2

1 Huang, Z., Laliberté, F., Tremblay, N.M., et al. A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. Anal Biochem 222 110-115 (1994).

2 Pickard, R.T., Chiou, X.G., Strifler, B.A., et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem 271 19225-19231 (1996).

Synonyms
  • Umbelliferyl Arachidonate
Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenoic acid,​ 2-​oxo-​2H-​1-​benzopyran-​7-​yl ester
CAS Number 161180-11-6
Molecular Formula C29H36O4
Formula Weight 448.6
Formulation A solution in ethanol
Purity ≥98%
λmax 282, 312 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​Oc1ccc2ccc(=O)​oc2c1
InCHI Code
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​1S/C29H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-28(30)​32-26-22-20-25-21-23-29(31)​33-27(25)​24-26/h6-7,9-10,12-13,15-16,20-24H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
InCHI Key
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SFTGFGOBCQCZDY-DOFZRALJSA-N

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7-hydroxycoumarinyl Arachidonate is available in the following screening library:

Size Price Quantity Subtotal
5 mg $28.00 $0.00
10 mg $53.00 $0.00
25 mg $126.00 $0.00
50 mg $224.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-24. Prices are subject to change without notice.

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