PAz-PC

Cayman Chemical Item Number 62924

1-Palmitoyl-2-Azelaoyl PC; Azelaoyl PC (CAS 117746-89-1)

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Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.1 Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.2 PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.3

1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105(8) 1095-1108 (2000).

2. Podrez, E.A., Batyreva, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem 277 (41) 38517-38523 (2002).

3. Itabe, H., Kudo, I., and Inoue, K. Preferential hydrolysis of oxidized phospholipids by peritoneal fluid of rats treated with casein. Biochim Biophys Acta 963 192-200 (1998 Aug 16).

Synonyms
  • 1-Palmitoyl-2-Azelaoyl PC
  • Azelaoyl PC
Formal Name 1-​O-​hexadecanoyl-​2-​O-​(9-​carboxyoctanoyl)-​sn-​glyceryl-​3-​phosphocholine
CAS Number 117746-89-1
Molecular Formula C33H64NO10P
Formula Weight 665.8
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=P([O-]​)​(OCC[N+]​(C)​(C)​C)​OC[C@H]​(OC(CCCCCCCC(O)​=O)​=O)​COC(CCCCCCCCCCCCCCC)​=O
InCHI Code
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​1S/C33H64NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-18-21-24-32(37)​41-28-30(29-43-45(39,40)​42-27-26-34(2,3)​4)​44-33(38)​25-22-19-16-17-20-23-31(35)​36/h30H,5-29H2,1-4H3,(H-,35,36,39,40)​/t30-/m1/s1
InCHI Key
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GHQQYDSARXURNG-SSEXGKCCSA-N

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PAz-PC is available in the following screening library:

Size Price Quantity Subtotal
1 mg $33.00 $0.00
5 mg $149.00 $0.00
10 mg $264.00 $0.00
25 mg $578.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-03. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Azelaoyl PAF
KDdiA-PC
Lyso-PC
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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