Item № 62935
CAS № 439904-34-4
Purity ≥98%
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500 µg $40.00 $0.00
1 mg $76.00 $0.00
5 mg $320.00 $0.00
10 mg $560.00 $0.00

Pricing updated 2016-02-06. Prices are subject to change without notice.

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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.1 Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.2 KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species.3 KDdiA-PC confers CD-36 scavenger receptor binding affinity to LDL at a frequency of only two to three KDdiA-PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL.

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Technical Information
Formal Name 1-palmitoyl-2-(4-keto-dodec-3-ene-dioyl)phosphatidylcholine
CAS Number 439904-34-4
Molecular Formula C36H66NO11P
Formula Weight 719.9
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C36H66NO11P/c1-5-6-7-8-9-10-11-12-13-14-15-18-21-24-35(41)45-30-33(31-47-49(43,44)46-29-28-37(2,3)4)48-36(42)25-22-19-16-17-20-23-32(38)26-27-34(39)40/h26-27,33H,5-25,28-31H2,1-4H3,(H-,39,40,43,44)/b27-26+/t33-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 84 Kb PDF

Download Safety Data Sheet (SDS) 29 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105(8) 1095-1108 (2000).

2. Podrez, E.A., Batyreva, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem 277 (41) 38517-38523 (2002).

3. Podrez, E.A., Batyreva, B., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem 277(41) 38503-38516 (2002).

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