S-Farnesyl Thioacetic Acid

Cayman Chemical Item Number 63260

FTA (CAS 135784-48-4)

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S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can also inhibit methylation of both farnesylated and geranylgeranylated substrates.1,2,3

1. Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochim Biophys Acta 1300 5-16 (1996).

2. Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett 295 189-194 (1991).

3. Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem J 284 835-840 (1992).

  • FTA
Formal Name (3,​7,​11-​trimethyl-​2E,​6E,​10-​dodecatrienyl)thioacetic acid
CAS Number 135784-48-4
Molecular Formula C17H28O2S
Formula Weight 296.5
Formulation A solution in ethanol
Purity ≥97%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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S-Farnesyl Thioacetic Acid is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $14.00 $0.00
5 mg $63.00 $0.00
10 mg $112.00 $0.00
50 mg $490.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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