Superoxide Dismutase Assay Kit
Cayman Chemical Item Number 706002
SOD Assay KitSee analysis tools… Pre-configured for analysis on
Significant amounts of superoxide dismutase (SOD) in cellular and extracellular environments are crucial for the prevention of diseases linked to oxidative stress. Mutations in SOD account for approximately 20% of familial amyotrophic lateral sclerosis (ALS) cases. SOD also appears to be important in the prevention of other neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s Diseases.1,2 The reaction catalyzed by SOD is extremely fast, having a turnover of 2 x 106 M−1sec−1 and the presence of sufficient amounts of the enzyme in cells and tissues typically keeps the concentration of superoxide very low.3 Quantification of SOD activity is therefore essential in order to fully characterize the antioxidant capabilities of a biological system. The Cayman Chemical SOD Assay kit is a fast and reliable assay for the measurement of SOD activity from plasma, serum, tissue homogenates, and cell lysates. SOD activity is assessed by measuring the dismutation of superoxide radicals generated by xanthine oxidase and hypoxanthine in a convenient 96 well format. A key feature of the kit is the inclusion of a quality-
1. Maier, C.M., and Chan, P.H. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist 8(4) 323-334 (2002).
2. Liu, D. The roles of free radicals in amyotrophic lateral sclerosis. J Mol Neurosci 7 159-167 (1996).
3. Malström, B., Andreasson, L., and Reinhammer, B. XIIB. 533 (1975).
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Maier, C.M., and Chan, P.H. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist 8(4) 323-334 (2002).
Malström, B., Andreasson, L., and Reinhammer, B. XIIB. 533 (1975).
Liu, D. The roles of free radicals in amyotrophic lateral sclerosis. J Mol Neurosci 7 159-167 (1996).
Pricing updated 2015-04-01. Prices are subject to change without notice.
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You may be eligible to receive a free sample Superoxide Dismutase Assay Kit under the Cayman Challenge program.
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