Wy 14643

Cayman Chemical Item Number 70730

Pirinixic Acid (CAS 50892-23-4)

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Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6

1. Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

2. Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol 48 559-567 (1995).

3. Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393 790-793 (1998).

4. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

5. Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6 1634-1641 (1992).

6. Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 378 651-655 (1997).

  • Pirinixic Acid
Formal Name [[4-​chloro-​6-​[(2,​3-​dimethylphenyl)amino]-​2-​pyrimidinyl]thio]-​acetic acid
CAS Number 50892-23-4
Molecular Formula C14H14ClN3O2S
Formula Weight 323.8
Formulation A crystalline solid
Purity ≥98%
λmax 244, 292 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
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Wy 14643 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $9.00 $0.00
10 mg $17.00 $0.00
50 mg $72.00 $0.00
250 mg $270.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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