Item № 70950
CAS № 34157-83-0
Purity ≥98%
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5 mg $61.00 $0.00
10 mg $116.00 $0.00
50 mg $488.00 $0.00
100 mg $854.00 $0.00

Pricing updated 2015-12-01. Prices are subject to change without notice.

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A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.4

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Technical Information
Formal Name 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
CAS Number 34157-83-0
Molecular Formula C29H38O4
Formula Weight 450.6
Purity ≥98%
Formulation A crystalline solid
λmax 253, 424 nm
SMILES O=C1C=C2C(=CC=C3[C@@]2(C)CCC2(C)[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@]32C)C(=O)O)C(=C1O)C
InChI Code 1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26?,27+,28-,29+/m1/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2. Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3. Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

4. Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

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