Celastrol

Cayman Chemical Item Number 70950

(CAS 34157-83-0)

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Description

A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.4

1. Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2. Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3. Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

4. Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

Formal Name 3-​hydroxy-​9β,​13α-​dimethyl-​2-​oxo-​24,​25,​26-​trinoroleana-​1(10),​3,​5,​7-​tetraen-​29-​oic acid
CAS Number 34157-83-0
Molecular Formula C29H38O4
Formula Weight 450.6
Formulation A crystalline solid
Purity ≥98%
λmax 253, 424 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C=C2C(=CC=C3[C@@]​2(C)​CCC2(C)​[C@@H]​4C[C@@]​(C)​(CC[C@]​4(C)​CC[C@]​32C)​C(=O)​O)​C(=C1O)​C
InCHI Code
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​1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)​15-20(30)​23(17)​31)​12-14-29(6)​22-16-26(3,24(32)​33)​10-9-25(22,2)​11-13-28(21,29)​5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)​/t22-,25-,26?,27+,28-,29+/m1/s1
InCHI Key
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KQJSQWZMSAGSHN-KUDKLYNCSA-N

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Celastrol is available in the following screening library:

Size Price Quantity Subtotal
5 mg $61.00 $0.00
10 mg $116.00 $0.00
50 mg $488.00 $0.00
100 mg $854.00 $0.00
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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