cis-Parinaric Acid

Cayman Chemical Item Number 71430

α-Parinaric Acid (CAS 18427-44-6)

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cis-Parinaric acid is a naturally occurring polyunsaturated fatty acid containing an unusual conjugated (Z,E,E,Z) tetraene. This chromophore provides for a natural fluorescence at 432 nm with an excitation wavelength at 320 nm. cis-Parinaric acid occurs naturally in the seeds of the Makita tree, a tropical rainforest tree indigenous to Fiji. Makita seeds are inedible, and this toxicity may be due at least in part to the unstable conjugated fatty acids, including cis-parinaric acid, contained within the seed. cis-Parinaric acid has been used for the measurement of phospholipase activity, lipase activity, and as an indicator of lipid peroxidation.1,2,3,4

1. Wolf, C., Sagaert, L., and Bereziat, G. A sensitive assay of phospholipase using the fluorescent probe 2-parinaroyllecithin. Biochem Biophys Res Commun 99 275-283 (1981).

2. Beisson, F., Ferté, N., Nari, J., et al. Use of naturally fluorescent triacylglycerols from Parinari glaberrimum to detect low lipase activities from Arabidopsis thaliana seedlings. J Lipid Res 40 2313-2321 (1999).

3. McGuire, S.O., James-Kracke, M.R., Sun, G.Y., et al. An esterification protocol for cis-parinaric acid-determined lipid peroxidation in immune cells. Lipids 32 219-226 (1997).

4. de Hingh, Y.C.M., Meyer, J., Fischer, J.C., et al. Direct measurement of lipid peroxidation in submitochondrial particles. Biochemistry 34 12755-12760 (1995).

  • α-Parinaric Acid
Formal Name 9Z,​11E,​13E,​15Z-​octadecatetraenoic acid
CAS Number 18427-44-6
Molecular Formula C18H28O2
Formula Weight 276.4
Formulation A crystalline solid
Purity >98% (may contain up to 5% trans-Parinaric acid)
λmax 292, 305, 319 nm
Stability 2 years
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
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cis-Parinaric Acid is available in the following screening library:

Size Price Quantity Subtotal
1 mg $26.00 $0.00
5 mg $117.00 $0.00
10 mg $208.00 $0.00
25 mg $455.00 $0.00
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Related Products

7-hydroxycoumarinyl Arachidonate
cis-Parinaric Acid methyl ester


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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

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