Cayman Chemical Item Number 71810

(CAS 293754-55-9)

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The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

1. Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).

Formal Name N-​(2,​2,​2-​trifluoroethyl)-​N-​[4-​[2,​2,​2-​trifluoro-​1-​hydroxy-​1-​(trifluoromethyl)ethyl]phenyl]-​benzenesulfonamide
CAS Number 293754-55-9
Molecular Formula C17H12F9NO3S
Formula Weight 481.3
Formulation A crystalline solid
Purity ≥98%
λmax 227, 265, 272 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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T0901317 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $25.00 $0.00
50 mg $106.00 $0.00
100 mg $188.00 $0.00
500 mg $375.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-28. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

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Ann Arbor, Michigan 48108 USA


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