Mn(III)TMPyP

Cayman Chemical Item Number 75852

See more

Description

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.1 SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.1,2 Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.2

1. Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

2. Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).

Formal Name Mn(III)tetrakis(1-​methyl-​4-​pyridyl)porphyrin pentachloride
Molecular Formula C44H36MnN8 · 5Cl
Formula Weight 909.0
Formulation A black crystalline solid
Purity >95%
λmax 455 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
C[n]​1ccc(cc1)​C1=c2ccc3C(=c4ccc5=C(c6cc[n]​(C)​cc6)​c6ccc7=C(c8cc[n]​(C)​cc8)​c8ccc1n8[Mn]​([n]​23)​([n]​67)​n45)​c1cc[n]​(C)​cc1
InCHI Code
Copy InCHI code to clipboard
​1S/C44H36N8.Mn/c1-49-21-13-29(14-22-49)​41-33-5-7-35(45-33)​42(30-15-23-50(2)​24-16-30)​37-9-11-39(47-37)​44(32-19-27-52(4)​28-20-32)​40-12-10-38(48-40)​43(36-8-6-34(41)​46-36)​31-17-25-51(3)​26-18-31;/h5-28H,1-4H3;/q+2;+5
InCHI Key
Copy InCHI key to clipboard
BGLSPIZKJUFKIN-UHFFFAOYSA-N

Download free InCHI Key generation software

Size Price Quantity Subtotal
10 mg $13.00 $0.00
25 mg $31.00 $0.00
50 mg $59.00 $0.00
100 mg $104.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-05. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

EUK 134
FeTMPyP
Mn(III)TBAP
Peroxynitrite
Show all 4 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...