Mn(III)TMPyP
Item № 75852
Purity >95%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
10 mg $13.00 $0.00
25 mg $31.00 $0.00
50 mg $59.00 $0.00
100 mg $104.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.1 SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.1,2 Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.2

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Technical Information
Formal Name Mn(III)tetrakis(1-​methyl-​4-​pyridyl)porphyrin pentachloride
Molecular Formula C44H36MnN8 · 5Cl
Formula Weight 909.0
Purity >95%
Formulation A black crystalline solid
λmax 455 nm
SMILES C[n]​1ccc(cc1)​C1=c2ccc3C(=c4ccc5=C(c6cc[n]​(C)​cc6)​c6ccc7=C(c8cc[n]​(C)​cc8)​c8ccc1n8[Mn]​([n]​23)​([n]​67)​n45)​c1cc[n]​(C)​cc1
InChI Code ​1S/C44H36N8.Mn/c1-49-21-13-29(14-22-49)​41-33-5-7-35(45-33)​42(30-15-23-50(2)​24-16-30)​37-9-11-39(47-37)​44(32-19-27-52(4)​28-20-32)​40-12-10-38(48-40)​43(36-8-6-34(41)​46-36)​31-17-25-51(3)​26-18-31;/h5-28H,1-4H3;/q+2;+5
InChI Key BGLSPIZKJUFKIN-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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Download Safety Data Sheet (SDS) 21 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

2. Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).

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