MEG (sulfate)

Cayman Chemical Item Number 81020

(CAS 3979-00-8)

MEG (sulfate) (CAS 3979-00-8)

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Description

MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.1 MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.2 MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.3

1 Southan, G.J., Zingarelli, B., O'Connor, M., et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117 619-632 (1996).

2 Szabó, C., Ferrer-Sueta, G., Zingarelli, B., et al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272 9030-9036 (1997).

3 Cuzzocrea, S., Zingarelli, B., Hake, P., et al. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24 450-459 (1998).

Formal Name (2-​mercaptoethyl)-​guanidine sulfate
CAS Number 3979-00-8
Molecular Formula [C3H9N3S]2 · H2SO4
Formula Weight 336.4
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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N/C(N([H]​)​CCS)​=N/[H]​.O=S(O)​(O)​=O

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Size Price Quantity Subtotal
5 mg $55.00 $0.00
10 mg $105.00 $0.00
50 mg $440.00 $0.00
100 mg $770.00 $0.00
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Pricing updated 2014-04-21. Prices are subject to change without notice.

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