MEG (sulfate)

Cayman Chemical Item Number 81020

(CAS 3979-00-8)

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MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.1 MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.2 MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.3

1. Southan, G.J., Zingarelli, B., O'Connor, M., et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117 619-632 (1996).

2. Szabó, C., Ferrer-Sueta, G., Zingarelli, B., et al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272 9030-9036 (1997).

3. Cuzzocrea, S., Zingarelli, B., Hake, P., et al. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24 450-459 (1998).

Formal Name (2-​mercaptoethyl)-​guanidine sulfate
CAS Number 3979-00-8
Molecular Formula [C3H9N3S]2 · H2SO4
Formula Weight 336.4
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
5 mg $55.00 $0.00
10 mg $105.00 $0.00
50 mg $440.00 $0.00
100 mg $770.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-05. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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