Cayman Chemical Item Number 81590

Stsp (CAS 62996-74-1)

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Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.1 It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.2 However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.3 The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.3,4

1. Tamaoki, T., Nomoto, H., Takahashi, I., et al. Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochem Biophys Res Commun 135 397-402 (1986).

2. McGlynn, E., Liebetanz, J., Reutener, S., et al. Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ζ in insect cells using recombinant baculovirus. J Cell Biochem 49 239-250 (1992).

3. Ruegg, U.T., and Burgess, G.M. Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci 10 218-220 (1989).

4. Li, H., and Förstermann, U. Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene. Mol Pharmacol 57 427-35 (1999).

  • Stsp
Formal Name 2,​3,​10,​11,​12,​13-​hexahydro-​10R-​methoxy-​9S-​methyl-​11R-​methylamino-​9S,​13R-​epoxy-​1H,​9H-​diindolo[1,​2,​3-​gh;3’,​2’,​1’-​lm]pyrrolo[3,​4-​j][1,​7]benzodiazonin-​1-​one
CAS Number 62996-74-1
Molecular Formula C28H26N4O3
Formula Weight 466.5
Formulation A solution in ethyl acetate
Purity ≥98%
λmax 241, 295, 337, 355, 373 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Staurosporine is available in the following screening library:

Size Price Quantity Subtotal
100 µg $46.00 $0.00
250 µg $104.00 $0.00
500 µg $184.00 $0.00
1 mg $276.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-30. Prices are subject to change without notice.

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