Staurosporine

Cayman Chemical Item Number 81590

Stsp (CAS 62996-74-1)

Staurosporine (CAS 62996-74-1)

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Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.1 It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.2 However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.3 The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.3,4

1 Tamaoki, T., Nomoto, H., Takahashi, I., et al. Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochem Biophys Res Commun 135 397-402 (1986).

2 McGlynn, E., Liebetanz, J., Reutener, S., et al. Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ζ in insect cells using recombinant baculovirus. J Cell Biochem 49 239-250 (1992).

3 Ruegg, U.T., and Burgess, G.M. Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci 10 218-220 (1989).

4 Li, H., and Förstermann, U. Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene. Mol Pharmacol 57 427-35 (1999).

Synonyms
  • Stsp
Formal Name 2,​3,​10,​11,​12,​13-​hexahydro-​10R-​methoxy-​9S-​methyl-​11R-​methylamino-​9S,​13R-​epoxy-​1H,​9H-​diindolo[1,​2,​3-​gh;3’,​2’,​1’-​lm]pyrrolo[3,​4-​j][1,​7]benzodiazonin-​1-​one
CAS Number 62996-74-1
Molecular Formula C28H26N4O3
Formula Weight 466.5
Formulation A solution in ethyl acetate
Purity >98%
λmax 241, 295, 337, 355, 373 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CN[C@H]​1CC2OC(C)​(C1OC)​n1c3ccccc3c3c4CNC(=O)​c4c4c5ccccc5n2c4c13
InCHI Code
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​1S/C28H25N4O3/c1-28-26(34-3)​17(29-2)​12-20(35-28)​31-18-10-6-4-8-14(18)​22-23-16(13-30-27(23)​33)​21-15-9-5-7-11-19(15)​32(28)​25(21)​24(22)​31/h4-11,17,20,26,29H,12-13H2,1-3H3/t17-,20-,26?,28+/m0/s1
InCHI Key
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QMONMSZBUAIQPV-DERHNSQFSA-N

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Staurosporine is available in the following screening libraries:

Size Price Quantity Subtotal
100 µg $46.00 $0.00
250 µg $104.00 $0.00
500 µg $184.00 $0.00
1 mg $276.00 $0.00
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Cart Total $0.00

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