FABP4 (human recombinant) FITC conjugated
Cayman Chemical Item Number 9001068
FABP4; A-FABP; Adipocyte-Fatty Acid Binding Protein; ALBP
recombinant N-terminal His-tagged protein expressed in E. coli
FABP4 is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high-affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated.1 Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP4 is composed of ten antiparallel β strands that form a barrel. FABP4 is a fat cell specific protein involved in facilitating the bidirectional flux of fatty acids into and out of the adipocyte in response to insulin and epinephrine.3,4,5
Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).
Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).
Trillou, C.R., Arnone, M., Delgorge, C., et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 284 R345-R353 (2003).
Hotamisligil, G.S., Johnson, R.S., Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377-1379 (1996).
Uysal, K.T., Scheja, L., Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9) 3388-3396 (2000).
- Adipocyte-Fatty Acid Binding Protein
||50 mM sodium phosphate, pH 7.2, containing 150 mM sodium chloride and 20% glycerol
in continental US; may vary elsewhere
InCHI Key generation software
Pricing updated 2014-04-16.
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