FABP4 (human recombinant) FITC conjugated

Cayman Chemical Item Number 9001068

A-FABP; Adipocyte FABP; ALBP; Fatty Acid Binding Protein 4; aP2

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Source: recombinant N-terminal His-tagged protein expressed in E. coli · MW: 19 kDa · FABP4 is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high-affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated.1 Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP4 is composed of ten antiparallel β strands that form a barrel. FABP4 is a fat cell specific protein involved in facilitating the bidirectional flux of fatty acids into and out of the adipocyte in response to insulin and epinephrine.3,4,5

1. Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).

2. Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).

3. Trillou, C.R., Arnone, M., Delgorge, C., et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 284 R345-R353 (2003).

4. Hotamisligil, G.S., Johnson, R.S., Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377-1379 (1996).

5. Uysal, K.T., Scheja, L., Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9) 3388-3396 (2000).

  • A-FABP
  • Adipocyte FABP
  • ALBP
  • Fatty Acid Binding Protein 4
  • aP2
Formulation 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
Purity ≥95%
Stability 9 months
Storage -80°C
Shipping Wet ice in continental US; may vary elsewhere

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Size Price Quantity Subtotal
25 µg $415.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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