Dihomo-γ-Linolenic Acid

Cayman Chemical Item Number 90230

cis-8,11,14-Eicosatrienoic acid; γ-​Homolinolenic acid; DGLA (CAS 1783-84-2)

See more


Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1.1,2 In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.3,4

1. Bell, J.G., Tocher, D.R., and Sargent, J.R. Effect of supplementation with 20:3(n-3), 20:4(n-6) and 20:5(n-3) on the production of prostaglandins E and F of the 1-, 2- and 3-series in turbot (Scophthalmus maximus) brain astroglial cells in primary culture. Biochim Biophys Acta 1211 335-342 (1994).

2. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

3. Kawashima, H., Tateishi, N., Shiraishi, A., et al. Oral administration of dihomo-γ-linolenic acid prevents development of atopic dermatitis in NC/Nga mice. Lipids 43(1) 37-43 (2007).

4. Takai, S., Jin, D., Kawashima, H., et al. Anti-atherosclerotic effects of dihomo-γ-linolenic acid in ApoE-deficient mice. J Atheroscer Thromb 16(4) 480-489 (2009).

  • cis-8,11,14-Eicosatrienoic acid
  • γ-​Homolinolenic acid
  • DGLA
Formal Name 8Z,​11Z,​14Z-​eicosatrienoic acid
CAS Number 1783-84-2
Molecular Formula C20H34O2
Formula Weight 306.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

Dihomo-γ-Linolenic Acid is available in the following screening libraries:

Size Price Quantity Subtotal
10 mg $25.00 $0.00
50 mg $75.00 $0.00
100 mg $95.00 $0.00
500 mg $438.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

14(15)-EpEDE methyl ester
Dihomo-γ-Linolenic Acid-d6
Dihomo-γ-Linolenic Acid methyl ester
Linolenic Acid ethyl ester
α-Linolenic Acid
α-Linolenic Acid-d14
γ-Linolenic Acid
Show all 10 Hide all but first 3


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...