9,12-Octadecadiynoic Acid

Cayman Chemical Item Number 90400

Ro 3-1314 (CAS 2012-14-8)

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Ro 3-1314 is an inhibitor of both COX and lipoxygenase.1,2 Ro 3-1314 inhibits ram seminal vesicle COX with a Ki of 0.6 µM.1 It is a more effective inhibitor of COX-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48 µM.2

1. Vanderhoek, J.Y., and Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim Biophys Acta 296 374-381 (1973).

2. Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).

  • Ro 3-1314
Formal Name 9,​12-​octadecadiynoic acid
CAS Number 2012-14-8
Molecular Formula C18H28O2
Formula Weight 276.4
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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9,12-Octadecadiynoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 mg $61.00 $0.00
5 mg $275.00 $0.00
10 mg $488.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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