3-Thiatetradecanoic Acid

Cayman Chemical Item Number 90500

3-TDA (CAS 116296-31-2)

3-Thiatetradecanoic Acid (CAS 116296-31-2)

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Description

3-Thiatetradecanoic acid (3-thia TDA) is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage. When chronically administered to rats, 3-thia TDA acts as a peroxisome inducer (PPAR ligand), increases fatty acid oxidation, and lowers plasma lipid levels.1 Incorporation of 3-thia TDA into dietary regimens at 150 and 300 mg/kg in rats induces the formation of oleic acid via Δ9-desaturase, and dose-dependently increases Δ9-desaturase mRNA levels.2

1 Asiedu, D.K., Froyland, L., Vaagenes, H., et al. Long-term effect of tetradecylthioacetic acid: A study on plasma lipid profile and fatty acid composition and oxidation in different rat organs. Biochim Biophys Acta 1300 86-96 (1996).

2 Madsen, L., Froyland, L., Grav, H.J., et al. Up-regulated Δ9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: Accumulation of a Δ9-desaturated metabolite of tetradecylthioacetic acid. J Lipid Res 38 554-563 (1997).

Synonyms
  • 3-TDA
Formal Name (undecylthio)-​acetic acid
CAS Number 116296-31-2
Molecular Formula C13H26O2S
Formula Weight 246.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCSCC(O)​=O
InCHI Code
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​1S/C13H26O2S/c1-2-3-4-5-6-7-8-9-10-11-16-12-13(14)​15/h2-12H2,1H3,(H,14,15)​
InCHI Key
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CZSSKBQAJULWPY-UHFFFAOYSA-N

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3-Thiatetradecanoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 mg $38.00 $0.00
5 mg $171.00 $0.00
10 mg $304.00 $0.00
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Pricing updated 2014-04-17. Prices are subject to change without notice.

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Related Products

2-Hydroxymyristic Acid
9-Thiastearic Acid
Myristic Acid ethyl ester
O-11
Oleic Acid
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