Cayman Chemical Item Number 90510

11-Oxatetradecanoic Acid (CAS 119290-12-9)

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O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 µM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3

1. Doering, T.L., Raper, J., Buxbaum, L.U., et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science 252 1851-1854 (1991).

2. Doering, T.L., Lu, T., Werbovetz, K.A., et al. Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci USA 91 9735-9739 (1994).

3. Langner, C.A., Lodge, J.K., Travis, S.J., et al. 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. J Biol Chem 267(24) 17159-17169 (1992).

  • 11-Oxatetradecanoic Acid
Formal Name 10-​propoxy-​decanoic acid
CAS Number 119290-12-9
Molecular Formula C13H26O3
Formula Weight 230.3
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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O-11 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $38.00 $0.00
5 mg $171.00 $0.00
10 mg $304.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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