O-11
Item № 90510
CAS № 119290-12-9
Purity >98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $38.00 $0.00
5 mg $171.00 $0.00
10 mg $304.00 $0.00

Pricing updated 2015-09-03. Prices are subject to change without notice.

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Description
Synonyms
  • 11-Oxatetradecanoic Acid

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 µM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3

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Technical Information
Formal Name 10-​propoxy-​decanoic acid
CAS Number 119290-12-9
Synonyms
  • 11-Oxatetradecanoic Acid
Molecular Formula C13H26O3
Formula Weight 230.3
Purity >98%
Formulation A solution in methyl acetate
SMILES CCCOCCCCCCCCCC(=O)​O
InChI Code ​1S/C13H26O3/c1-2-11-16-12-9-7-5-3-4-6-8-10-13(14)​15/h2-12H2,1H3,(H,14,15)​
InChI Key HSRAJJQTYQHRSA-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 111 Kb PDF

Download Safety Data Sheet (SDS) 29 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Doering, T.L., Raper, J., Buxbaum, L.U., et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science 252 1851-1854 (1991).

2. Doering, T.L., Lu, T., Werbovetz, K.A., et al. Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci USA 91 9735-9739 (1994).

3. Langner, C.A., Lodge, J.K., Travis, S.J., et al. 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. J Biol Chem 267(24) 17159-17169 (1992).

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