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Join us! · ENDO 2015 · San Diego, California · March 5-8, 2015 · Booth 1935
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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

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Research Area · Apoptosis

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Item № Product Sizes & Pricing CAS Purity Image Exclusive Introduction Date Mojo Plain Text Name Synonyms Keywords Interest
15929 10058-F4 403811-55-2 ≥95% 2014-04-18 1.592044198895 10058-f4 cancers apoptosis genes regulations transcription factors oncogenes Myc Max dimer regulates proteins c-Myc cells growth 10058F4 10058 F4 permeable thiazolidione inhibits inhibition inhibitors proliferation cycles arrest myeloid humans leukemia metabolized metabolism mice tumors in vivo nuclear neuroblastoma n-Myc n c lipids glucose 1.592044198895
15088 1,2-Dipalmitoyl-sn-glycero-3-PS (sodium salt) 145849-32-7 ≥98% 2013-10-31 7.318031767955 1-2-dipalmitoyl-sn-glycero-3-ps-sodium-salt 1,2-DPPS; 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine 40290-42-4 lipids phospholipids liposomes membranes apoptosis dipalmitoyl sn glycerol phospho serines PS phosphatidylserine anionic long-chains long chains 16:0 16 0 palmitic acids sn-1 sn-2 sns 1 one 2 two sn1 sn2 sodium salts 7.318031767955
14438 1,5-Isoquinolinediol 5154-02-9 ≥98% 2013-04-11 3.334654671156 1-5-isoquinolinediol NSC 65585; 1,5-Dihydroxyisoquinoline Inhibitors oxidative injury apoptosis DNA damage inhibits inhibitions injuries poly(ADP-ribose) ADP PARPs PARP1 PARP-1 repari oxidant stress cells death induced 40048-26-8 NSC65585 NSC-65585 NSCs 65585 3.334654671156
34720 15(S)-HETE 54845-95-3 ≥98% 41.994460405156 15-s-hete soybean 15-LOs asthma airway 15-lipoxygenases monohydroxy fatty acids 15S-HETES 15-HETES arachidonic 15(S)-HETEs 15(S)HETEs potato polyunsaturated 15HETEs 41.994460405156
334720 15(S)-HETE-d8 84807-87-4 ≥99% deuterated forms (d1-d8) 55.934438305709 15-s-hete-d8 GC/MS deuterium isotopes 15-HETE-d8 standards 15S-HETE-d8 15(S)HETE-d8 deuterated GC-MS LC/MS LC-MS 15-HETEs 15(S)-HETEs 15S-HETEs 15(S)HETEs hydroxy fatty acids mass spectrometry 15HETE 55.934438305709
534721 15(S)-HETE EIA Kit - 92.348977900552 15-s-hete-eia-kit 15(S)-HETE ELISA Kit solid plates 15(S)-HETEs 15S-HETEs measures kits eias enzyme immunoassays ELISAs 15(S)HETEs 15HETEs assays 92.348977900552
10007251 15(S)-HETE Lipid Maps MS Standard 54845-95-3 ≥98% 2009-02-17 16.386170845729 15-s-hete-lipid-maps-ms-standard soybean 15-LOs asthma airway 15-lipoxygenases monohydroxy fatty acids 15S-HETES 15-HETES arachidonic 15(S)-HETEs 15(S)HETEs potato polyunsaturated MS mass spectrometry standards 15HETE 16.386170845729
13583 1-Aminodecylidene bis-Phosphonic Acid (sodium salt) Exclusive - ≥95% 2012-04-02 5.265745856353 1-aminodecylidene-bis-phosphonic-acid-sodium-salt 1-Amindecane-1,1-Diphosphonic Acid 15049-93-1 sphingomyelinases ceramides apoptosis cells signaling sphingomyelin inhibitors inhibits inhibition phosphorycholine acids dexamethasone HepG2 5.265745856353
15108 1-O-Octadecyl-2-O-methyl-sn-glycerol 83167-59-3 ≥95% 2013-11-06 0.681252302026 1-o-octadecyl-2-o-methyl-sn-glycerol PIA 7; 2-Methyl-1-octadecyl-sn-glycerol ethers lipids ET-18-OCH3 ET 18 OCH3 ET18OCH3 edelfosine phosphotidylinositol analogs PIAs Akts anticancers anti-cancers anti cancers apoptosis octadecyl O methyl sn glycerols metabolites pleckstrin homology domains serine threonine serine/threonine kinases cells endogenous DAGs intracellular signaling signal transductions lipids 0.681252302026
10005229 2,3-DCPE (hydrochloride) 1009555-55-8 ≥98% 2006-09-15 13.611261510128 2-3-dcpe-hydrochloride apoptosis Bcl-XL p21 ERK cancers cells cycles proapoptotic in vitro S-phase arrest upregulate activates activation 418788-90-6 13.611261510128
11097 25-hydroxy Cholesterol 2140-46-7 ≥98% 2012-02-08 21.204058648533 25-hydroxy-cholesterol 16505-96-7 oxysterol cholesterol SREBP sterols regulatory elements binding proteins atherosclerosis anticancer apoptosis immunosuppressive Bcl-2 caspases atherosclerosis antitumor tumors LXR-RXR ligands T cells macrophages 21.204058648533
11099 25-hydroxy Cholesterol-d6 88247-69-2 ≥99% deuterated forms (d1-d6) 2012-01-27 3.872822702159 25-hydroxy-cholesterol-d6 deuterated deuterium GC/MS GC-MS LC/MS LC-MS mass spectrometry MS 16505-96-7 oxysterol cholesterol SREBP sterols regulatory elements binding proteins atherosclerosis anticancer apoptosis immunosuppressive Bcl-2 caspases atherosclerosis antitumor tumors LXR-RXR ligands T cells macrophages 3.872822702159
10397 3-amino Benzamide 3544-24-9 ≥98% 2011-10-07 1.540852900552 3-amino-benzamide 3-Carboxamidoaniline; 3-(Aminocarbonyl) Aniline poly(ADP-ribose) polymerases PARPs DNA repairs DNA strands breaks apoptosis inflammation atherosclerosis neruogenesis cancers angiogenesis signaling cellular responses inhibits inhibitor inhibition telomere shortening shortens stimulates mediated mediates PARP-mediated 1.540852900552
15419 3-AP 143621-35-6 ≥95% 2014-01-22 11.548999150021 3-ap NSC 663249; 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone; Triapine™ 236392-​56-​6 ribonucleotide reductase inhibitors inhibits inhibitions DNA synthesis cancers anti-tumors tumors anti antitumor iron chelator R2/p53R2 subunits ER stress UPR unfolded proteins response apoptosis oxidative injury 3AP 3 APs aminopyridine carboxyaldehyde thiosemicarbazone in vitro NSCs 663249 NSC663249 NSC-663249 OCX-191 OCX191 OCXs 191 Pans pan-811 811 pan811 11.548999150021
13856 5-Nitroso-8-quinolinol 3565-26-2 ≥95% 2012-10-25 22.999530386740 5-nitroso-8-quinolinol Hydron III; NSC 3852 5-nitrosooxine NSC3852 NSC-3852 hydron 3 HDACs inhibitors antitumors oxidative stress ROS apoptosis antiproliferative cancers cells differentiation Toxoplasma gondii Plasmodium falciparum inhibits inhibitions Zn2+ chelation motif SAHA MCF-7 MCF7 tumors agents 22.999530386740
17459 (5Z)-7-Oxozeaenol New 253863-19-3 ≥99% 2015-02-19 87.777777777778 -5z-7-oxozeaenol L-783,279; FR 148083; LL-Z 1640-2 66018-38-0 1198574-97-8 natural product inhibitor TAK1 MAPKKK anti-inflammation NF-κB JNK p38 apoptosis 66018-38-0 5Z-7 biochemical protein kinase inhibit (-)- C-292 F-152-A1 selective inhibit resorcylic lactone fungi TAB1 irreversibly block IL-1-induced activation cyclooxygenase-2 (COX-2) ear swelling TRAIL TNF α-induced in vitro 87.777777777778
10009856 7-AAD Cell Viability Assay Kit - 2008-10-29 38.884489089792 7-aad-cell-viability-assay-kit 7-Amino Actinomycin D Cell Viability Kit kits 7AAD measurement cells fixation blocking cytoxicity effects environmental toxins drug fluorescence fluorescent cell-based assays cell based assay cba 38.884489089792
600120 7-AAD/CFSE Cell-Mediated Cytotoxicity Assay Kit - 2009-08-05 56.369522494081 7-aad-cfse-cell-mediated-cytotoxicity-assay-kit 7-Amino Actinomycin D/5-(6)-Carboxyfluorescein Diacetate Succinimidyl Ester 7-amino actinomycin D/5-(6)-carboxyfluorescein diacetates succinimidyls esters assays kits measuring measurement kits 5-(6) 5,6 5-6 7AAD cells cytoxicity cell-based cba cytolysis target effector T lymphocytes NK natural killer autoimmune systems pathological cancers multiple sclerosis granule exocytosis pathways Fas diseases graft host 51chromium 51Cr green fluorescent fluorescence probes red propidium iodide dead effector carboxyfluorescein succinimidyl esters dyes damaged DNA deoxyribonucleic acids quantify quantification single staining 56.369522494081
11397 7-Aminoactinomycin D 7240-37-1 ≥95% 2012-07-06 1.807902045691 7-aminoactinomycin-d 7-AAD; NSC 239759 3H-phenoxazine dye viability apoptosis cytotoxicity DNA flow cytometry fluorescence cells PE FITC 7 aminoactinomycin D 1.807902045691
53400 (±)9,10-DiHOME 263399-34-4 ≥98% 7.541823204419 -9-10-dihome Leukotoxin diol epoxides epoxygenase leukotoxin cytochrome P450 (+/-)9(10)-DiHOMes (+/-)9,10-DiHOMes CYP450 7.541823204419
10009993 (±)9,10-DiHOME-d4 - ≥99% deuterated forms (d1-d4) 2007-06-01 5.102624309391 -9-10-dihome-d4 Leukotoxin diol-d4 epoxides epoxygenase leukotoxin cytochrome P450 (+/-)9(10)-DiHOMes (+/-)9,10-DiHOMes CYP450 deuterated duteriums 5.102624309391
52400 9(10)-EpOME - ≥98% 7.754834254144 9-10-epome 9,10-EODE; Leukotoxin epoxides epoxygenasse leukotoxin cytochrome P450 (+/-)9(10)-EpOMEs (+/-)9,10-EpOMEs epoxy fatty acids (±)9(10)-epome 7.754834254144
10009995 9(10)-EpOME-d4 - ≥99% deuterated forms (d1-d4) 2007-06-01 3.942320441989 9-10-epome-d4 9,10-EODE-d4; Leukotoxin-d4 epoxides epoxygenasse leukotoxin cytochrome P450 (+/-)9(10)-EpOMEs (+/-)9,10-EpOMEs epoxy fatty acids deuterated deuterium 3.942320441989
14580 A-438079 (hydrochloride) 899431-18-6 ≥98% 2013-05-20 9.957569060774 a-438079-hydrochloride 899507-36-9 receptors antagonists pains apoptosis oxidative stress neurosciences nucleotides P27 inhibits inhibitors inhibitions calcium flux animals cells A438079 A-438079 A 438079 HCl 9.957569060774
16233 ABT-199 1257044-40-8 ≥98% 2014-08-07 4.364640883978 abt-199 GDC 0199 1379647-79-6 Bcl-2-selective inhibitor Bcl 2 Bcl2 Bcl-2 selectives apoptosis antitumor BH3 mimetic chronic lymphocytic leukemia cancer GDC0199 ABT199 4.364640883978
11500 ABT-263 923564-51-6 ≥98% 2013-12-19 14.734060773480 abt-263 Navitoclax; A-855071 inhibitors apoptosis cancers intracellular signaling ABTs ABT263 263 potent anti-apoptotic antiapoptotic anti apoptotic Bcl-2 Bcl2 Bcls 2 two proteins BH3 BH-3 BHs 3 three homology tumors therapeutics therapy chemotherapeutics cells 1000696-69-4 As 855071 A855071 A-855071 Bim regression .beta. b β catenin .beta.-catenin b-catenin β-catenin Bcl-XL XL BCL-w w 14.734060773480
11501 ABT-737 852808-04-9 ≥98% 2014-01-02 13.110414364640 abt-737 inhibitors apoptosis cancers intracellular signaling inhibits inhibitions anti-apoptotic antiapoptotic anti apoptotic Bcl-2 Bcl2 Bcl 2 two ABTs 737 ABT737 potent cell-permeable cells permeable mimetics BH3 BH-3 BHs 3 three homology Bcl-XL BclXL XL Bcl-w Bclw w proteins tumors therapeutics radiation 13.110414364640
11505 ABT-888 (hydrochloride) 912445-05-7 ≥98% 2014-01-03 5.590817412533 abt-888-hydrochloride Veliparib inhibitors DNA damages repairs cancers apoptosis autophagy inhibits inhibitions ABTs ABT888 888 HCl poly(ADP-ribose) polymerases PARPs oral orally bioavailable PARP1 PARP2 PARPs PARP-1 PARP-2 1 2 one two breaks radiation alkylation chemotherapies cancers cells 912444-00-9 chemotherapy 5.590817412533
14459 Ac-DEVD-AFC 201608-14-2 ≥98% 2013-05-13 10.830159049054 ac-devd-afc Caspase-3 Substrate (Fluorogenic); N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin fluorescents fluorescence detections probes enzymes substrates activity apoptosis N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethyl coumarins caspase-3 caspases 3 CPP32 CPP-32 CPP 32 poly ADP adenosine diphosphates riboses polymerases PARP AcDEVDAFC Ac DEVD AFC amino acids sequences free fluorogenic N-Acetyl-Asp-Glu-Val-Asp-AFC 10.830159049054
14986 Ac-DEVD-AMC 169332-61-0 ≥95% 2014-05-08 6.407077961940 ac-devd-amc N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin; Caspase-3 Substrate (Fluorogenic) caspases caspase-3 fluorogenic substrates cleavage apoptosis 3 three AcDEVDAMC Ac DEVD AMC cleaved apoptosis fluorescent probes 7-amino-4-methylcoumarin 7-amino-4-methyl coumarin N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methyl coumarin enzymes Ac-Asp-Glu-Val-Asp-MCA 6.407077961940
14465 Ac-DEVD-CMK 285570-60-7 ≥98% 2013-05-13 3.964576427256 ac-devd-cmk Caspase-3 Inhibitor III; Ac-Asp-Glu-Val-Asp-CMK inhibitors caspase-3 apoptosis Ac-DEVD-CMK caspase-6 caspase-7 caspase-8 caspase-10 inhibits inhibitions caspases 3 6 7 8 10 III cells permeables cell-permeable irreversible AcDEVDCMK Ac DEVD CMK deaths 3.964576427256
14460 Ac-DEVD-pNA 189950-66-1 ≥95% 2013-05-23 3.856737700605 ac-devd-pna N-Acetyl-Asp-Glu-Val-Asp-p-Nitroanilide apoptosis enzymes substrates cells deaths dyes indicators CPP32 CPP-32 CPP 32 caspase-3 caspases 3 1 4 6 7 caspase-1 caspase-1 caspase-4 caspase-6 caspase-7 cleavages ADP-ribose adenosines diphosphates ADP riboses poly polymerases PARP DEVD aminos acids sequences chromophores AcDEVD pNAs para para-nitro anilines colorimetric stubstrates 3.856737700605
10008051 Acid Phosphatase Colorimetric Assay Kit - 2006-09-20 6.430718232044 acid-phosphatase-colorimetric-assay-kit AP aps hydrolase eznymes prostate pap tartrate resistant assays 6.430718232044
17051 Ac-LEHD-AFC​ New 210345-03-2 ≥95% 2014-12-03 9.351880127239 ac-lehd-afc Caspase-9 substrate (fluorogenic); N-Acetyl-Leu-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin caspase caspase-4 caspase-5 caspase-9 fluorogenic substrate cleavage apoptosis AcLEHDAFC caspase4 caspase5 caspase9 fluorescent detection free AFC 7-amino-4-trifluoromethylcoumarin biochemical enzyme probe 9.351880127239
14991 Ac-LETD-AFC 210345-02-1 ≥95% 2014-05-06 6.612799263352 ac-letd-afc N-Acetyl-Leu-Glu-Thr-Asp-7-amido-4-Trifluoromethylcoumarin; Caspase-8 Substrate (Fluorogenic) caspases caspase-8 fluorogenic substrates cleavage cleaved apoptosis fluorescence caspases 8 caspase8 eight enzymes fluorescent probes Ac-Leu-Glu-Thr-Asp-AFC Ac-Leu-Glu-Thr-Asp-AFC N-Acetyl-Leu-Glu-Thr-Asp-7-Amido-4-trifluoromethyl coumarin AFC 7-Amino-4-trifluoromethylcoumarin 6.612799263352
16605 Actinonin​ 13434-13-4 ≥98% 2014-11-05 6.565243282649 actinonin Ro 06-1467; (-)-Actinonin protease inhibitor aminopeptidase antibiotic matrix metalloproteinase MMP peptide deformylase PDF meprin α antitumor anticancer apoptosis mitochondria infectious disease cancer antibiotic inhibit mitochondrial biology biochemical peptidomimetic Actinomyces MMP-1 MMP1 MMP-2 MMP2 MMP-3 MMP3 MMP-7 MMP7 MMP-8 MMP8 MMP-9 MMP9 MMP-10 MMP10 MMP-12 MMP12 MMP-13 MMP13 herbicide plastid enzyme N-terminal processing plastid-encoded protein human zinc endopeptidase cleaves tumor cell invasion degradation induce animal model actinonine CONA 57 CON 57 6.565243282649
14988 Ac-VDVAD-AFC 210344-94-8 ≥95% 2014-05-07 8.254125230202 ac-vdvad-afc N-Acetyl-Val-Asp-Val-Ala-Asp-7-amido-4-Trifluoromethylcoumarin; Caspase-2 Substrate (Fluorogenic) Caspases 2 caspase-2 fluorogenic substrates cleavages apoptosis amino acids aa nitric oxides oxide-induced induced activations human neuroblastomas lines peptides 8.254125230202
14989 Ac-VEID-AMC 219137-97-0 ≥95% 2014-05-08 3.373726212400 ac-veid-amc N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-Methylcoumarin; Caspase-6 Substrate (Fluorogenic) caspases caspase-6 caspase-8 fluorogenic substrates cleavage apoptosis lamin A enzymes fluorescent probes Ac VEID AMC AcVEIDAMC cleaved 6 8 six eight proteases Mch2 N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-methyl coumarin 7-amido-4-methylcoumarin 7-amino-4-methylcoumarin Ac-Val-Glu-Ile-Asp-MCA 3.373726212400
14992 Ac-WEHD-AFC 210344-99-3 ≥95% 2014-05-06 3.252007366482 ac-wehd-afc Caspase-5 Substrate (Fluorogenic); N-Acetyl-Trp-Glu-His-Asp-7-amido-4-Trifluoromethylcoumarin; Caspase-1 Substrate (Fluorogenic) caspases caspase-5 5 five caspase-1 one 1 caspase-4 four 4 fluorogenic substrates cleavage cleaved apoptosis fluorescence fluorescent groups I enzymes probes N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salts N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethyl coumarin N-Acetyl-Trp-Glu-His-Asp-AFC AFC 7-amino-4-trifluoromethylcoumarin 7-amino-4-trifluoromethylcoumarin 3.252007366482
10006908 Adipogenesis Assay Kit - 2006-08-18 74.594030454116 adipogenesis-assay-kit obese obesity cells cycle differentiation inhibits inhibitors inhibition adipocytes cancers origin 3T3-L1 model drug screening adipokines endocrinology cell-based assays cell based assay cba 74.594030454116
10009381 Adipolysis Assay Kit - 2007-07-30 45.774945497984 adipolysis-assay-kit obese obesity cells cycle differentiation inhibits inhibitors inhibition adipocytes cancers origin 3T3-L1 model drug screening adipokines lipolysis 3T3L1 kits assays FFA adipocytes endocrinology cell-based assay cell based assay cba 45.774945497984
10010129 AG-041R Exclusive 199800-49-2 ≥98% 2008-12-16 16.929502762431 ag-041r CCKs gastrin receptors antagonist cancers proliferations apoptosis NS-398 NS398 NS 398 16.929502762431
10010311 AG-490 133550-30-8 ≥98% 2007-12-01 11.461687845304 ag-490 Tyrphostin AG-490 PTK tyrosine kinase inhibitors inhibition inhibits antiproliferatives tyrphostins leukemia Jak-2 Jak2 AG490 134036-52-5 B 42 B-42 B42 11.461687845304
17259 AG-957 New 140674-76-6 2015-02-10 2.124011049723 ag-957 NSC 654705; Tyrphostin AG-957 p210 tyrosine kinase inhibitor inhibit apoptosis P13K AKT phosphorylation K562 cell 2.124011049723
360773 AIF Blocking Peptide - 0.377532228361 aif-blocking-peptide Programmed Cell Death Protein 8; Apoptosis-Inducing Factor human peptides controls factors WB western blots blotting antibodies apoptosis 0.377532228361
160773 AIF Polyclonal Antibody - 0E-12 aif-polyclonal-antibody Apoptosis-Inducing Factor; Programmed Cell Death Protein 8 apoptosis antibodies western blots blotting WB antisera antiserum factors cancers immunoblotting 0E-12
14870 Akt Inhibitor VIII 612847-09-3 ≥98% 2013-10-24 14.715704419889 akt-inhibitor-viii inhibitors cancers signals transductions angiogenesis apoptosis kinases Akts VIII potent allosteric inhibits inhibitions Akt-1 Akt-2 Akt1 Akt2 1 one 2 two serine-threonine serines threonines cells permeable blocking blocks blockage insulin regulation forkhead box 01 FOXO1 hepatoma Akti-1/2 ½ Akti proteins 14.715704419889
14863 Akt Inhibitor X 925681-41-0 ≥95% 2013-08-14 10.234447513812 akt-inhibitor-x 201788-90-1 phenoxazines Akts mTOR p70S6 kinases S6 ribosomal proteins apoptosis cells signalings inhibitors inhibits inhibitions permeable derivatives suppresses suppressions insulin-like insulin liked growth factors 1 one IGFs 1 IGF-1 IGF1 stimulated blocks blocking Rh1 Rh-1 Rhs Rh-18 Rh18 Rh-30 Rh30 p70S6 kinases S6 S-6 proteins apoptosis intracellular signals transduction 10.234447513812
11677 Aloe-emodin New 481-72-1 2015-01-20 5.047790055248 aloe-emodin 3-Hydroxymethylchrysazine; NSC 38628; Rhabarberone 1,8-dihydroxy-3-hydroxymethylanthraquinone aloe-emodol NSC38628 3-hydroxymethylchrysazin biochemical inhibitor inhibit P-388 leukemia P388 cancer mice in vitro vivo antineuroectodermal tumor activity anti-neuroectodermal induce apoptosis disruption mitochondria membrane potential antitumor anti-tumor interferon-inducing agent 5.047790055248
11308 Anisomycin 22862-76-6 ≥98% 2012-02-13 15.946012891344 anisomycin Wuningmeisu C; Flagecidin; NSC 76712 2322-08-9 11023-48-6 antibiotics inhibitors proteins DNA stress-activated kinases MAP caspase-8 cancers immunology immunosuppressant pyrrolidines Streptomyces griseolus synthesis signal transduction pathways T cells skin mice anoikis epithelial apoptosis ECM distal tumors prostate metastasis NSC76712 NSC-76712 15.946012891344
600300 Annexin V FITC Assay Kit - 2010-05-11 81.410444391064 annexin-v-fitc-assay-kit assays kits measures measurements apoptosis cells death cycles tissues homeostasis dysregulation neurodegenerative diseases ischemic damages autoimmune disorders cancers drugs discovery signaling pathways membranes phospholipids phosphatidylserines phosphatidylethanolamines leaflets bilayers externalizations residues plasma phospholipids binding proteins fluorochrome-labeled fluorochromes fluorescence microscopy flow cytometry FC plate readers TUNEL TdT-mediated dUTP Nick-End Labeling analysis ISEL in situ end labeling DNA laddering detection fragmentation FITC-conjugated fluoresceins 81.410444391064
360780 Apaf-1 Blocking Peptide - 0.754143646409 apaf-1-blocking-peptide peptides controls apoptosis cell death caspases CED-4 Apaf2 Apaf3 Apaf-2 Apaf-3 Apafs antibodies Apaf1 CED4 protease-activating factors proteases 0.754143646409
160780 Apaf-1 Polyclonal Antibody - 0.440147329650 apaf-1-polyclonal-antibody Apoptosis Protease-Activating Factor 1 apoptosis cell death caspases CED-4 Apaf2 Apaf3 Apaf-2 Apaf-3 Apafs antibodies Apaf1 CED4 western blots blotting WB protease-activating factors proteases antisera antiserum cancers immunoblotting 0.440147329650
160737 ARC Polyclonal Antibody - 5.410607734806 arc-polyclonal-antibody Apoptosis Repressor with CARD apoptosis cell death domain DD CARD caspase antibodies western blots blotting WB antisera antiserum cancers immunoblotting IP immunoprecipitation 5.410607734806
16677 Astragaloside A​ 83207-58-3 ≥98% 2014-10-22 1.521178637200 astragaloside-a Astragaloside IV; Astramembrannin I 84687-43-4 biochemical natural product cardiology vascular disease neuroscience apoptosis stem cell research immunology inflammation signal transduction inhibitor bioactive saponin traditional Chinese medicine dried root plant genus Astragalus IV protective effect cardiovascular immune digestive nervous system protect cardiomyocyte ischemia/reperfusion ischemia reperfusion inhibit TNF-α TNFα angiogenesis differentiate neural neuroregeneration Astragalin A 1.521178637200
600140 Autophagy/Cytotoxicity Dual Staining Kit - 2009-07-14 59.463805248619 autophagy-cytotoxicity-dual-staining-kit assays kits measuring measurement MDC cell-based autophagy cells cytotoxicity staining autofluorescent autofluorescence substances multilamellar body bodies ions trapping mechanisms membranes lipids probes autophagic vacuoles cultured degradation digestion intracellular lysosomes organelles misfolded proteins microorganisms cytoplasms double membranes autophagosomes autolysosomes homeostasis dysregulation cancers infections aging degenerative diseases stress death apoptosis 59.463805248619
16731 AZ 960 905586-69-8 ≥98% 2014-10-07 3.292141923804 az-960 Janus-associated kinase JAK2 myeloproliferative disease V617F mutation leukemia lymphoma ATL cancer signal transduction apoptosis Bcl-2 inhibit JAK 2 cytoplasmic cytoplasm tyrosine signaling cytokine growth factor receptor mutation valine phenylalanine aggressive adult T cell leukemia lymphoma in vitro STAT3/5 phosphorylation proliferation SET-2 two human megakaryoblastic line induce death lymphotropic virus type 1-infected downregulation downregulate down regulate family protein Bcl2 AZ960 SET2 AZ 960 3.292141923804
11599 AZD 6244 606143-52-6 ≥98% 2013-10-29 28.640570150711 azd-6244 ARRY-142886; Selumetinib; NSC 741O78; Cl-1040 865610-​79-​3 inhibitors inhibits inhibitions cancers apoptosis proteins kinases signals transductions intracellular AZDs AZD-6244 6244 AZD6244 potent selective MEKs MEK1 MEK2 MEK-1 MEK-2 1 2 one two tumor growth suppressing suppression proto-oncogenes proto-oncogenes proto oncogenes Ras Raf MEK-1/2 MEK1/2 ½ NSCs 741O78 NSC-741O78 NSC741O78 ARRYs 142886 ARRY142886 ARRY-142886 Cl-1040 Cl4040 Cls 4040 Gs 00039805 G-00039805 G00039805 28.640570150711
10010266 BAY-11-7082 19542-67-7 ≥98% 2008-07-25 44.883460572576 bay-11-7082 inhibitors inhibits inhibition NFkB NF-.kappa.B NF-kB NF-kappaB TNF.alpha. TNFa TNFalpha I.kappa.B-.alpha. IkB-a IkappaB-alpha inflammation cytokine cell adhesion ICAM-1 ICAM1 VCAM-1 VCAM1 E-selection Eselection Bay 11-7082 BAY-117821 Bay117082 BAY 117821 44.883460572576
14795 BAY-11-7085 196309-76-9 ≥98% 2014-01-29 7.062424033149 bay-11-7085 inhibits inhibitions inhibitors NF-kB apoptosis inflammation nuclear receptors signals transduction intracellular signaling BAYs 117085 11 7085 BAY-11-7085 BAY11-7085 BAY-117085 BAY117085 BAY11 BAY-11 irreversible IκBα IkBa IkappaBalpha I.kappa.B.alpha. NF-κB NF-kB NF-.kappa.B NF-kappaB genes expressions blocks blockages cells adhesions 117083 phosphorylation cytokines lipopolysaccharides activates activations 7.062424033149
10009644 BAY-43-9006 284461-73-0 ≥98% 2011-09-13 41.108465745310 bay-43-9006 Nexovar®; Sorafenib inhibitors raf-1 b-raf receptors tyrosine kinases VEGF VEGFR PDGF PDGFR cancers angiogenesis apoptosis tumors cells cellular proliferation Flt-3 c-KIT carcinoma growth factor tosylate 41.108465745310
11571 Bexarotene 153559-49-0 ≥98% 2012-04-06 4.425469613260 bexarotene LG 100069; Targretin; Ro 26-4455; SR 11247; LGD 1069 retinoid X receptors ligands agonist RXR genes expression cancers alzheimers diseases apoptosis angiogenesis metastasis cells proliferations β-amyloid amyloids βamyloid LG 100069 1069 69 LG-100069 LG-1069 LG-69 LGD 1069 LGD-1069 LGD1069 LG100069 LG1069 LG69 RO 26-4455 RO26-4455 RO-26-4455 RO 264455 RO-264455 RO264455 SR 11247 SR-11247 SR11247 targret targretin targretyn targrexin 4.425469613260
17265 BI 6C9 New 791835-21-7 2015-02-11 0E-12 bi-6c9 tbid inhibitor inhibit antiapoptotic apoptosis cell biology 0E-12
16608 BIBR 1532​ 321674-73-1 ≥95% 2014-10-10 1.452854511971 bibr-1532 Telomerase Inhibitor X biochemical inhibitor inhibit cancer apoptosis BIBR1532 mixed-type non-competitive noncompetitive telomerase reverse transcriptase catalytic subunit TERT induce senescence cell triple negative breast glucose restriction potent 1.452854511971
10011385 Bim/BOD (IN) Polyclonal Antibody - 2008-04-10 0.741988950276 bim-bod-in-polyclonal-antibody apotosis BH3 Bcl-2 Bcl-XL cancer immunoblotting WB IHC antibodies western blotting antiserum blots immunohistochemistry 0.741988950276
16999 BIX02189 New 1265916-41-3 ≥98% 2015-01-22 56.916666666667 bix02189 1094614-85-3 biochemical inhibitor signal transduction intracellular signaling protein kinase neuroscience cancer cardiology angiogenesis apoptosis inhibit signal transduction MEK5 ERK5 MEK ERK MAP2K5 MAP-2K5 MAPK7 MAP-K7 pathway stress-induced neuronal survival neuron cardiac development BIX-02189 transcriptional activation transcription downstream MEF2C MEF-2C MEK1/2 MEK-1/2 ERK1/2 ERK-1/2 sorbitol-induced phosphorylation HeLa cell nerve growth factor-mediated neurite outgrowth myeloid differentiation 56.916666666667
13013 (−)-Blebbistatin 856925-71-8 ≥98% 2009-04-16 287.128303078137 -blebbistatin (S)-Blebbistatin inhibitors muscles myosin ATPase smooth muscle bleb apoptosis cell migration chemotaxis cytokinesis cells division growth UV light blebs (-)-(S)-Blebbistatin 287.128303078137
13165 (+)-Blebbistatin 1177356-70-5 ≥98% 2009-04-16 95.839889502762 -blebbistatin (R)-Blebbistatin inhibitors muscles myosin ATPase smooth muscle bleb apoptosis cell migration chemotaxis cytokinesis cells division growth UV light (+)-(R)-Blebbistatin inhibition inhibited 95.839889502762
13186 (±)-Blebbistatin 674289-55-5 ≥98% 2009-06-09 141.743729281768 -blebbistatin inhibitors muscles myosin ATPase smooth bleb apoptosis cells migration chemotaxis cytokinesis division growth UV lights 141.743729281768
16118 Boc-D-FMK 187389-53-3 ≥95% 2014-07-10 10.245531767955 boc-d-fmk Boc-Asp(OMe)-FMK; Boc-D(OMe)-FMK; BAF; Boc-D-Fluoromethylketone apoptosis cells biology inhibitors inhibits inhibitions proteases inhibitor irreversible pan-caspases pan caspases Boc D FMK fluoromethyl ketone methyl esters TNF-α TNF-.alpha. TNF-alpha TNF-a TNFs .alpha. alpha a α neutrophils bile ducts ligation hepatocytes renal endothelial pharmacophore cathepsins H L (S)- 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester BAF Boc-Asp(OMe)-fluoromethylketone Boc-Asp(OMe)-fluoromethyl ketone BocD.fmk BocD-fmk 10.245531767955
14484 Buthionine Sulfoximine 83730-53-4 ≥98% 2013-05-21 40.179392265194 buthionine-sulfoximine L-Buthionine-S,R-Sulfoximine; BSO; NSC 326231 oxidative injury injuries inhibitors inhibits inhibitions cancers apoptosis cells deaths glutathiones stress γ-glutamylcysteine g-glutamylcysteine gamma-glutamylcysteine .gamma.-glutamylcysteine synthetases GSH drugs drug-resistance resistances BSO irreversibles synthases tissues damages toxicity chemotherapeutics agents tumors L-glutathiones rates limiting rate-limiting enzymes induces inductions synthesis toxic limits limiters 40.179392265194
10007958 C-12 NBD Ceramide 202850-01-9 ≥98% 2006-04-12 3.440653775322 c-12-nbd-ceramide N-C12-NBD-D-erythro-Sphingosine ceramides cerimidases fluorescent fluorescence substrates N-acyl fatty acids sphingosine bases isoforms neutral alkalines catalytic pH analogs hydrolyzed hydrolysis P. aeruginosa mouse liver mammalian cells lines kinases sphingomyelin synthases 3.440653775322
10008097 C-12 NBD-dihydro-Ceramide 474943-05-0 ≥98% 2006-04-13 3.855041436463 c-12-nbd-dihydro-ceramide N-C12-NBD-D-erythro-dihydro-Sphingosine ceramides cerimidases fluorescent fluorescence substrates N-acyl fatty acids sphingosine bases isoforms neutral alkalines catalytic pH analogs hydrolyzed hydrolysis P. aeruginosa mouse liver mammalian cells lines kinases sphingomyelin synthases 3.855041436463
10681 C-16 Ceramide 24696-26-2 ≥98% 2011-03-08 5.276543891958 c-16-ceramide Palmitoyl Ceramide sphingomyelins apoptosis ceramides lipids membranes second messengers C16 ceramides longevity assurance homologs 6/LASS6 Ceramides C 16 5.276543891958
10724 C-20 Ceramide 7344-02-7 ≥98% 2011-03-08 2.911903007980 c-20-ceramide sphingomyelins apoptosis differentiation brains C20-ceramide C20:0 ceramides 20:0 synthesis 1 2 synthases 2.911903007980
10005270 (±)-C75 191282-48-1 ≥98% 2004-09-22 40.707716390424 -c75 inhibits inhibitors inhibition fatty acids synthases FAS cerulenin cytotoxicity apoptosis cancers anorexigenic stable weight loss feeding endocrinology 40.707716390424
13112 Carboplatin 41575-94-4 ≥95% 2013-12-04 11.255966850829 carboplatin NSC 241240; NSC 201345; Paraplatin®; Ribocarbo-L platinum antineoplastic DNA repairs damages apotosis anti cancers anticancers anti-cancer cytotoxic agents ovarian lungs crosslinks crosslinking chemotherapy antineoplastic anti-neoplastic neoplastic adducts tumors solids inhibits inhibitions inhibitors CBDCA carbomedac carboplatinium carbosin cycloplatin JMs 8 JM8 JM-8 eight NSCs 201345 241240 NSC-201345 NSC-241240 NSC201345 NSC241240 paraplatin ribocarbo L 70903-55-8 110681-25-9 936543-00-9 replication transcription 11.255966850829
13916 Caspase-14 Monoclonal Antibody (Clone 70A1426) - 2010-09-13 1.872741181470 caspase-14-monoclonal-antibody-clone-70a1426 caspases cysteine proteases mediators programmed cells death apoptosis prodomain catalytic subunits pentapeptides QACRG embryonic tissues ontogenesis western blots immunoblotting blotting WB FC flow cytometry antibodies 14 fourteen 1.872741181470
13907 Caspase-1 Monoclonal Antibody (Clone 14F468) - 2010-07-12 1.682526703499 caspase-1-monoclonal-antibody-clone-14f468 IL-1β Converting Enzyme antibodies caspases caspase1 cysteine proteases cell death apoptosis prodomain catalytic subunits receptors ligand growth factor CED-3 CED3 western blots blotting immunoblotting WB immunohistochemistry IHC proteins IL-1β ICE IL1β IL-1b IL1b apoptosis inflammatio 1.682526703499
14464 Caspase-3/7 Inhibitor I 1110670-49-9 ≥98% 2013-05-13 2.486363950276 caspase-3-7-inhibitor-i inhibitors caspase-3 caspase-7 caspases 3 7 inhibits inhibitions potent reversible isatins sulfonamide-based sulfonamides 9 1 2 4 6 8 apoptosis camptothecin-treated camptothecin treated treats Jurkat cells condrocytes hydrophobic residues S2 catalytic cysteines I 2.486363950276
10009135 Caspase-3 Fluorescence Assay Kit - 2007-08-06 42.390319566705 caspase-3-fluorescence-assay-kit assays kits caspases fluorescent cells death apoptosis necrosis aspartate-specific cysteinyl fluorescence fluorometric proteases family mitochondrial mitochondria electrons transport oxidative phosphorylation adenosine triphosphate ATP cytochromes C caspase-9 anti-cancers drugs N-Ac-DEVD-N'-MC-R110 HTS high throughput screening N-Ac-Asp-Glu-Val-Asp-CHO cell-based assay cell based assay cba 42.390319566705
360745 Caspase-3 (human) Blocking Peptide - 0.331357537490 caspase-3-human-blocking-peptide Apopain; CPP32; ICE3; Yama control peptides blots blotting western cpp-32 ice-3 apoptosis effectors caspases cell death wb antibodies 0.331357537490
160745 Caspase-3 (human) Polyclonal Antibody - 6.988064252097 caspase-3-human-polyclonal-antibody Apopain; CPP32; ICE3; Yama antibodies blots blotting western cpp-32 ice-3 apoptosis effectors caspases cell death wb antisera antiserum cancers immunoblotting IHC immunohistochemistry 6.988064252097
13909 Caspase-3 Monoclonal Antibody (Clone 31A1067) - 2010-08-10 2.040172245693 caspase-3-monoclonal-antibody-clone-31a1067 CPP32; Yama; ICE3; Apopain caspases caspase 3 cysteine proteases cell death apoptosis antibodies western blots blotting immunoblotting WB immunohistochemistry IHC frozen paraffin-embedded paraffin embedded yama CPP32 apopain codes PARP poly(ADP-ribose) polymerase DNA-PK DNAPK DNA PK actin GAS2 pro-caspase procaspase pro CrmA small large subunits 2.040172245693
13911 Caspase-3 Monoclonal Antibody (Clone 31A893) - 2010-09-07 2.040172245693 caspase-3-monoclonal-antibody-clone-31a893 Apopain; CPP32; ICE3; Yama caspases caspase 3 cysteine proteases cell death apoptosis antibodies western blots blotting immunoblotting WB immunohistochemistry IHC frozen paraffin-embedded paraffin embedded yama CPP32 apopain codes PARP poly(ADP-ribose) polymerase DNA-PK DNAPK DNA PK actin GAS2 pro-caspase procaspase pro CrmA small large subunits 2.040172245693
13913 Caspase-8 Monoclonal Antibody (Clone 90A992) - 2010-09-09 1.680991225219 caspase-8-monoclonal-antibody-clone-90a992 caspases eight 8 cysteine proteases key mediators programmed cells death apoptosis FLICE ICE CD95 CD-95 CDs 95 subunits a2be active enzyme inhibitors inhibits inhibition antibodies western blots blotting immunoblotting WB immunohistochemistry IHC flow cytometry FC 1.680991225219
13915 Caspase-9 (carboxy-terminal divergent) Polyclonal Antibody - 2010-09-09 1.780817896219 caspase-9-carboxy-terminal-divergent-polyclonal-antibody CTD caspases nine 9 apaf-1 apaf1 apaf 1 one binds binding activation activates active cleaves proteases proteolytic cleavage apoptosis inducers TNFa TNF-a TNF a TNFα TNF-α α TNFalpha TNF-alpha alpha TNF.alpha. TNF-.alpha. .alpha. TRAIL CD-95 CD95 CDs 95 FADD TRADD tissues C-terminal C-terminus terminal terminus C proteins peptides Casp-9 Casp9 Casp genes cytoplasm nucleus cytochrome c dominant-negative western blots blotting immunoblotting WB 1.780817896219
160790 Caspase-9 Polyclonal Antibody - 6.769820953550 caspase-9-polyclonal-antibody Apaf-3; ICE-LAP6; MCH6 apoptosis cell death Apaf-1 apafs caspase-3 caspases antibodies Apaf1 western blots blotting WB an tisera antiserum cancers immunoblotting 6.769820953550
72510 CAY10406 - ≥98% 13.357596685082 cay10406 selectively inhibits inhibitors caspase-3 caspase-7 apoptosis apoptotic signal inhibition CAY-10406 13.357596685082
70635 CAY10416 443919-96-8 ≥95% 2007-07-24 8.025451197053 cay10416 COX-2 cyclooxygenases 5-LO lipoxygenases inflammation inhibitors prostates cancers PC3 LNCaP carcinomas apoptosis inhibition inhibits chemotherapy cells lines 8.025451197053
10005019 CAY10433 537034-17-6 ≥95% 2005-01-05 18.010313075506 cay10433 N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide; BML-210 HDAC deacetylases histone inhibits inhibitors inhibition cancer cells differentiation gene expression regulation Trichostatin A nuclear extracts deacetylation transcription factors FOXO3 SIRT1 H2O2 hydrogen peroxides BML210 18.010313075506
10004177 CAY10443 582314-48-5 ≥98% 2004-06-17 0.565303867403 cay10443 (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate DNA binding anti-oncogenic apoptosis cancer p53 re-activator reactivator induces apoptotic re-activation reactivation antioncogenic 0.565303867403
10008872 CAY10503 890854-82-7 ≥98% 2007-08-02 41.512928176796 cay10503 apoptosis antiproliferation cancers differentiation HL60 cells cycles proliferative positive markers CD14 CD11b CD11c monocytic granulocytic 41.512928176796
10010043 CAY10561 Exclusive 933786-58-4 ≥98% 2008-03-06 3.595994475137 cay10561 Pyrazolylpyrrole ERK Inhibitor MEK Ras Raf ERK2 proliferation cell cycles cancers apoptosis inhibition inhibit inhibitors 3.595994475137
10011256 CAY10577 300675-28-9 ≥95% 2008-09-02 0.887661141805 cay10577 inhibitors inhibits inhibition CK2 kinase cell signaling apoptosis cancers 0.887661141805
10011264 CAY10578 19231-60-8 ≥95% 2008-08-26 0.794682320442 cay10578 inhibitors inhibits inhibition kinase cell signaling CK2 apoptosis cancers isoindolineacetic acids 0.794682320442
13291 CAY10616 Exclusive 586410-08-4 ≥98% 2009-12-01 10.268110497237 cay10616 resveratrols apoptosis cancers leukemia HL-60 cells HL60 HL 60 multidrug-resistance multidrug resistance multi-drug multi-drug-resistant daunorubicin etoposides citarabines phenols cytarabines HL60R 10.268110497237
13836 CAY10625 137346-42-0 ≥95% 2010-06-23 5.206055248618 cay10625 apoptosis Smac Diablo Survivin cancers antagonists INCENP doxorubicin caspase-3 caspase-7 Aurora B kinases Borealin caspases cell-permeable antagonists smac/diable smac-diablo 5.206055248618
10004985 Caylin-1 Exclusive 1207480-88-3 ≥98% 2005-09-09 13.524191002367 caylin-1 caylin1 mdm-2 cancer Nutlin-3 analogs p53 inhibits inhibitors inhibition interaction Mdm2 negative regulators activity chlorine substituents phenyl rings growth HCT-116 cells promotes 13.524191002367
10005002 Caylin-2 Exclusive 1392830-09-9 ≥98% 2004-07-12 14.255628453038 caylin-2 apoptosis cancer p53 inhibits inhibitors induces apoptotic re-activation reactivation antioncogenic tumors xenografts HCT-116 caylin2 14.255628453038
13172 CBHA 174664-65-4 ≥98% 2009-06-24 12.729625409249 cbha m-Carboxycinnamic Acid bis-Hydroxamide; Histone Deacetylase Inhibitor II histones deacetylase HDACs HDAC1 HDAC3 apoptosis cancers neuroblastoma tumors retinoic acids inhibitors inhibits inhibition 12.729625409249
10339 CD25 Monoclonal PE Antibody (Clone 143-13) Exclusive - 2010-06-09 12.939383765405 cd25-monoclonal-pe-antibody-clone-143-13 Interleukin-2 receptor α subunit; Tac; IL-2Rα; p55 antibodies antiserum FC flow cytometry immunocytochemistry ICC interleukins 2 IL-2 IL2 cytokines immunochemical immunohistochemistry IHC frozen tissues sections 12.939383765405
10004837 CD27 Monoclonal Antibody (Clone 203.6) - 2005-09-16 4.767016574585 cd27-monoclonal-antibody-clone-203-6 antibodies antisera antiserum IHC immunohistochemistry ICC immunocytochemistry FACS flow cytometry type II transmembranes glycoproteins leukocytes proteins tetraspanin superfamily antigens alternative splicing isoforms human B cells pro-B plasma T macrophages neutrophils platelets erythrocytes Anti-CD37 immunophenotyping neoplasia hairy chronic lymphocytic non-Hodgkin's lymphoma expression lymphocytes T cells NK activated memory monocytes granulocytes dendritic B anti-CD45 mAB lymphoid malignancies malignant cancer FC 4.767016574585
10004835 CD34 Monoclonal Antibody (Clone ICO-115) - 2005-09-16 3.187730556736 cd34-monoclonal-antibody-clone-ico-115 antibodies antisera antiserum ICC immunocytochemistry FACS flow cytometry type I transmembranes glycoproteins proteins antigens isoforms stem cells embryonic fibroblasts neurons Anti-CD34 differential staining acute leukemias cancers malignant malignancies ICO115 FC 3.187730556736
10004718 CD37 Monoclonal Antibody (Clone IPO-24) - 2005-09-16 3.491275740833 cd37-monoclonal-antibody-clone-ipo-24 antibodies antisera antiserum IHC immunohistochemistry ICC immunocytochemistry FACS flow cytometry type III transmembranes glycoproteins leukocytes proteins tetraspanin superfamily antigens alternative splicing isoforms human B cells pro-B plasma T macrophages neutrophils platelets erythrocytes Anti-CD37 immunophenotyping neoplasia hairy chronic lymphocytic non-Hodgkin's lymphoma expression lymphocytes T cells NK activated memory monocytes granulocytes dendritic B anti-CD45 mAB lymphoid malignancies malignant cancer FC 3.491275740833
71610 CD437 125316-60-1 ≥95% 2013-12-12 4.261714022625 cd437 AHPN atypical retinoid RRM retinoid-related retinoid related molecules agonist retinoic acids receptors RARγ antitumors anti tumors anti-tumor cancers anti-cancers anticancers apoptosis cells cycles arrest DNA damage CDs CD-437 437 RARs RARgamma RARg RAR.gamma. cytotoxic melanoma breasts non-small lungs prostate 4.261714022625
10004604 CD95 Monoclonal Antibody (Clone IPO-4) - 2004-06-17 0.423167587477 cd95-monoclonal-antibody-clone-ipo-4 APO-1; Fas; Tumor Necrosis Factor Receptor Superfamily, Member 6; TNFRSF6; Apoptosis Antigen; APT glycoproteins blots blotting antibodies antisera antiserum DNA binding anti-oncogenic apoptosis cancers p53 re-activator reactivator induces apoptotic re-activation reactivation antioncogenic immunocytochemistry immunohistochemistry IHC icc FC flow cytometry 0.423167587477
81035 CDDO 218600-44-3 ≥95% 2012-10-26 9.308198895027 cddo Bardoxolone; RTA 401 Nrf2 antioxidant ARE Keap1 oxidative stress inflammations cancers apoptosis inducers inhibitors inhibits inhibitions iNOS COX-2 COX2 ROS RNS heme oxygenase-1 oxygenase eotaxins eotaxin-1 PPARgamma PPAR.gamma. PPARg PPAR-gamma PPAR-.gamma. PPAR-g PPARγ PPAR-γ oleanane triterpenoid cellular nitric oxide INFγ INF-γ INF-gamma INF-.gamma. INF-g INFg INF.gamma. INFgamma ROS/RNS peroxisome proliferator activated receptor RTA401 RTA-401 9.308198895027
11883 CDDO methyl ester 218600-53-4 ≥98% 2012-10-26 23.814276243094 cddo-methyl-ester RTA 402; NSC 713200; TP-155; Bardoxolone methyl iNOS COX-2 COX2 apoptosis inflammations cancers signalings antidiabetic activity oxidative stress NF-κB NFκB NF-kappaB NFkappaB NF.kappa.B NFkB NF-.kappa.B NF-kappaB NF-kB C28 C-28 CDDOs nitric oxide Nrf2 antioxidant ARE Keap1 oxidative stress inflammations cancers apoptosis inducers inhibitors inhibits inhibitions iNOS COX-2 COX2 ROS RNS heme oxygenase-1 oxygenase eotaxins eotaxin-1 PPARgamma PPAR.gamma. PPARg PPAR-gamma PPAR-.gamma. PPAR-g PPARγ PPAR-γ oleanane triterpenoid cellular nitric oxide INFγ INF-γ INF-gamma INF-.gamma. INF-g INFg INF.gamma. INFgamma ROS/RNS peroxisome proliferator activated receptor RTA402 RTA-402 NSC713200 NSC-713200 TP155 TP 155 23.814276243094
90001845 CDDO-TFEA Exclusive 932730-52-4 ≥95% 2014-05-14 9.495764272560 cddo-tfea RTA 404; CDDO-Trifluoethyl Amide; TP-500 neuroprotection anti-inflammatory anti inflammatory antiinflammatory multiple sclerosis cytokines triterpenoids Nrf2 antioxidants oleanolic acids experimental autoimmune encephalomyelitis EAE myelin amyotrophic lateral sclerosis ALS Huntington’s Huntingtons Huntington disease neuroblastoma neurodegeneration apoptosis CDDOs TFEA CDDOTFEA signals transductions oxidative injury inhibitors inhibits inhibitions inflammation cancers steroids oxysterols RTAs 404 RTA404 RTA-404 TP500 TPs 500 Tp-500 synthetics anti-cancer anticancer neuroprotective blood brains blood-brains barriers ewing's sarcoma ewing ewings neurosciences CDDO trifluoroethyl amides CDDO-tfea 9.495764272560
10008672 Celecoxib 169590-42-5 ≥98% 2013-08-08 21.962553100061 celecoxib Onsenal; Xilebao; SC-58635; Celebrex™; Celebra; YM-177 anti-inflammatory diaryl heterocycle inhibitors inhibits inhibitions COXs COX2 2 two cyclooxygenases cyclooxygenase-2 COX-2 antitumors anti-tumors anti tumors antiinflammatory inflammatory cancers apoptosis selective therapeutics gastrointestinal NSAIDs cardiovascular chemopreventive proapoptotic sulfonamides nonsteroidal drugs YM 177 YMs 177 YM177 SC58635 SC 58635 SCs 58635 eurocox medicoxib apopeotsis non-steroidal 21.962553100061
10009349 Cell Cycle Phase Determination Kit - 2007-04-20 42.282689917127 cell-cycle-phase-determination-kit assays kits measures measurements microscopy flow cytometry plate readers regulators cells transcription factors DNA proteins division proliferation induction inhibition fixation permeabilization staining sub-G1 G0 G2 S propidium iodide apoptosis cancer cell-based assay cell based assay cba 42.282689917127
10005647 Cerulenin 17397-89-6 ≥98% 2004-09-01 33.647642725598 cerulenin tumor cells fatty acid synthases FAS inhibits inhibitors inhibition cytotoxicity apoptosis cancer diet obesity D02.065.327 33.647642725598
16242 CGK733 905973-89-9 ≥98% 2014-08-07 1.968149171270 cgk733 ATM/ATR Kinase Inhibitor ATM ATR kinases inhibitor ATM/ATR CGK733 CGK-733 prematurely senescent cancer cells death apoptosis p21 antiproliferation DNA damage repair ataxia-telangiectasia mutated ATM RAD3 expression 1.968149171270
16553 CHIR124​ 405168-58-3 ≥98% 2014-09-22 0.853591160221 chir124 checkpoint 1 kinase inhibitor Chk1 topoisomerases I radiosensitizations p53 cells cycles antitumor anti-tumor apoptosis cancer DNA damage repair biochemical selective CHIR-124 permeable quinolone-based in vitro selective selectivity inhibit poison ionizing radiations growth mutant solid tumor xenograft model potentiate 0.853591160221
11988 Cinnabarinic Acid 606-59-7 ≥98% 2013-05-28 1.299660615627 cinnabarinic-acid 11129-24-1 receptors neurosciences apoptosis cells deaths agonists partial mGlu4 mGlu-4 4 mGlus phenoxazinones oxidatives dimerizations 3-hydroxyanthranilic hydroxyanthranilic 3-hydroxyl anthranilic acids 3-HAA 3HAA 3 HAA metabolisms tryptophan kynurenic pathways types 4 type-4 fours metabotropics glutamate subtypes cinnabaric T 1.299660615627
13119 Cisplatin 15663-27-1 ≥95% 2014-05-22 18.476301752949 cisplatin Cisplatinum; CDDP; NSC 119875; cis-Diamminedichloroplatinum 96081-74-2 936542-99-3 cancers apoptosis infectious diseases DNA damages platinum-containing platinum containing alkylating agents therapy therapies treatments RecA recombinases M. tuberculosis blocking blocks blockages proteins splicing cells growths repairs chemotherapy chemo abiplatin biocisplatinum briplatin CACP CDDP CP ethypharm CPDC CPDD CPPD cismaplat cisplatino cisplatinum cisplatyl citoplatino DDP antitumor anti-tumor anti tumors fauldiscopla IA-call IA calls lederplatin liplacis lipoplatin NSCs 119875 NSC119875 NSC-119875 neoplatin platamine platiblastin platidiam platinex platinol AQ platinoxan platistin platosin rand randa SPIs 077 SPI077 SPI-077 SPI077B103 077B103 TRs 170 TR170 TR-170 cis-DDP cis-diaminedichloroplatinum cis-diaminodichloroplatinum cis-diamminedichloroplatinum cis-platin cis-platine cos-platinous cis-platinum testicular ovarian cervical bladders lungs inhibits inhibitions inhibitors cis-diamminedichloroplatinum(II) dichloride 18.476301752949
11320 Citrinin 518-75-2 ≥98% 2012-02-21 4.223005524861 citrinin NSC 186 11003-17-1 16051-41-5 mycotoxin food contaminants cytotoxin mycotoxic Balkan nephropathy yellow rice fever apoptosis tubulin polymerization microtubule organization Penicillium citrinum P. citrinum NSC-186 NSC186 4.223005524861
16134 Clodronate (sodium salt hydrate) 88416-50-6 ≥95% 2014-08-12 4.641325966850 clodronate-sodium-salt-hydrate Clodronic acid bisphosphonates bones resorption osteoclasts inhibitors osteoporosis cancers macrophages apoptosis 10596-23-3 22560-50-5 non-nitrogenous non nitrogenous nonnitrogenous treatments metabolic metabolism metabolized diseases binds hyrdroxyapatite crystals affinity growths resorptions intracellular β-γ-methylene β γ methylene βγ-methylene analogs ATP cytotoxic cytotoxicity liposomes liposome-encapsulated encapsulated encapsulates biological selective selectively depletes depletion depleted macrophage-like like macrophagelike cells bone-related research immunology inhibitors inhibitions inhibiting signals signaling phosphonic acids disodium salts tetrahydrates clodronates 4.641325966850
14125 Clofarabine 123318-82-1 ≥98% 2013-04-11 3.885994475138 clofarabine Clolar; Evoltra nucleotides inhibitors inhibits cancers inhibitions apoptosis Clofarex CAFdA nucleosides analogs leukemias mitochondrial transmembranes potentionals ribonucleotides reductases DNA deoxyribonucleic acids polymerases polymerase-a polymerase-α polymerase-.alpha. polymerase-alpha alpha .alpha. a α cytoxins cytotoxic K562 K-562 K 562 myelogenous growths solid tumors induces inductions primary chronic lymphocytic lymphocytes 3.885994475138
15364 Colcemid 477-30-5 ≥98% 2014-01-07 2.500662983425 colcemid Demecolcine; NSC 3096 inhibitors cytoskeletal research apoptosis inhibits inhibitions microtubule colchicine derivative tubulin polymerization suppresses suppression microtubule dynamicity cells migrations blocks blockage assembly arrests metaphase synchronize synchronizing karyotyping cytogenetic alkaloid H3 alkaloid-H3 C12669 C-12669 Cs 12669 ciba 12669A colchamin deacetylmethylcolchicine demecolcin desacetylmethylcolchicine desmecolcine kolchamin NSCs NSC-3096 NSC3096 3096 omain omaine reichsteins F santavys substance 2.500662983425
14951 Concanavalin A 11028-71-0 2013-09-25 2.395690607735 concanavalin-a 12612-33-8 lectin jack beans C. ensiformis canavalia glycoproteins agglutination mitogenesis apoptosis glycolipids affinity chromatography purifications autoimmune hepatitis AIH immune response T cells T-cells cross-links cross links cell-surface surface concanacalin-A Con A ConA Con-A plants immunology biology carbohydrates 2.395690607735
14426 Cordycepin 73-03-0 ≥98% 2013-05-23 3.217753222836 cordycepin NSC 401022; 3'-Deoxyadenosine; NSC 63984 153-49-1 48171-89-7 nucleosides analogs 3’-deoxyadenosine polyadenylation inhibitors inhibits inhibitions DNA deoxyribonucleic acids ribonucleic synthesis RNA synthesis anti-proliferative pro-apoptotic anti-inflammatory antiproliferative anti proliferative proapoptotic pro apoptotic inflammatory antiinflammatory sinensis 3’-dATP NSCs NSC-401022 NSC-63984 NSC401022 NSC63984 anti-inflammatories cordyceps triphosphates ATP-dependent biological poly A tails mRNA length activates AMPK kinases mTOR signals signaling 3.217753222836
14743 Costunolide 553-21-9 ≥98% 2013-08-19 6.586065070595 costunolide Costus lactone; Melampolide; NSC 106404 11028-78-7 25333-06-6 46814-17-9 62458-56-4 80750-19-2 126621-28-1 cancers inhibitors apoptosis sesquiterpenes lactones plants extracts medicines oils cells Akt endometriotic epithelial STAT3 STAT-3 STATs 3 three THP-1 THP1 THP 1 one telomerase NALM-6 NALMs NALM6 six 6 NSC106404 NSC-106404 NSCs 106404 costus 6.586065070595
16981 CPI-613 New 95809-78-2 ≥98% 2015-01-16 57.635254757520 cpi-613 biochemical inhibitor cancer metabolism apoptosis mitochondrial biology CPI613 inhibit α-ketoglutarate dehydrogenase αketoglutarate lipoic acid analog tumor cells burst reactive oxygen species death in vivo in vitro antitumor anti-tumor apoptotic nonapoptotic pathway 57.635254757520
16426 CUDC-101 1012054-59-9 ≥98% 2014-08-27 3.450015785319 cudc-101 inhibitors histones deacetylases cancers receptors biochemistry proteins kinases apoptosis epigenetics signals transductions intracellular signaling biochemicals 1012060-66-0 CUDC 101 CUDC101 multitargets multi-targets targets multi combines functional groups potent humans epidermal growths factors HERs HDACs blocks tyrosines EGFRs HER1s HER2 HER-1 HERs ones twos HER-2 2s 1s inhibits classes I II activities activity prevents preventions cells in vitro slows tumors induces inducing regressions xenografts models acquired resistances single-targets singletargets singles blocks blocked blocking proliferations proliferating proliferates reduces migrations 3.450015785319
16779 CX-4945​ 1009820-21-6 ≥98% 2014-11-04 1.863219361340 cx-4945 Silmitasertib biochemical inhibitor kinase protein cancer apoptosis intracellular signaling CK4945 inhibit orally bioavailable casein CK 2α II two competes ATP adenosine triphosphate binding site catalytic CK2α subunit proliferation cell line overexpress overexpression tumor growth breast pancreatic xenograft mice mouse block stem glioblastoma acute myeloid leukemia Cdc2-like Clk 1 2 3 Clk1 Clk2 Clk3 interfering interfere alternative splice splicing 1.863219361340
14748 Cyclic Pifithrin-α (hydrobromide) 511296-88-1 ≥95% 2013-08-16 7.447872928176 cyclic-pifithrin-hydrobromide Cyclic PFT-α; Pifithrin-β; PFT-β 60477-34-1 inhibitors cancers neurosciences intracellulars signalings apoptosis cells biology signals transductions autophagy inhibits inhibitions pifithrins pifithrin-a pifithrin-alpha pifithrin-.alpha. pifithrin-α pifithrin-beta pifithrin-β pifithrin-.beta. pifithrin-b β α beta alpha .beta. .alpha. b a h2O2 IGROV-1 IGROV1 IGROV 1 one A2780 A-2780 A 2780 HCT-116 HCT116 HCT 116 H460 H 460 H-460 antimicrotubules anti-microtubule anti microtubule DNA damages UV ultraviolet radiation melanocytes p53 transcription hydrogen peroxide H2O2 growth 7.447872928176
14126 Cycloheximide 66-81-9 ≥95% 2013-06-25 13.681812154696 cycloheximide NSC 185; Naramycin A 4630-76-6 6399-67-3 17974-04-8 21059-09-6 antibiotics inhibitors inhibits inhibitions proteins synthesis eukaryotes translation elongation apoptosis S. griseus Streptomyces cells types molecular biology biologies ribsome profiling profiles translational half-life half life NSCs 185 NSC185 NSC-185 naramycin-A acti-aid actiaid acti aids acti-dione actidione acti dione BR PM TGF actidion CHX cicloheximide FT 3422-2 FT-3422-2 FT3422-2 34222 3422 2 FT-34222 FT-3422 FT34222 FT3422 LDNs LDN97549 LDN-97549 97549 NM-MCD 80 NMMCD-80 naramycin microcapsule D 80 NM-MCU TZA Us 4527 U-4527 U4527 13.681812154696
14159 Daunorubicin (hydrochloride) 23541-50-6 ≥98% 2013-04-10 5.041215469613 daunorubicin-hydrochloride NDC 0082-4155; Ondena; RP 13057 daunomycin antitumors antibiotics acute myeloid leukemia AMLs apoptosis drugs resistance anticancers anti-cancers anti cancers induces apoptosis U937 HL-60 HL60 HLs 60 cells tiggers ROS dependent sphingomyelin ceramide pathways DNA binding binds AP1 AP-1 AP 1 HCL 20830-81-3 52471-42-8 1087700-63-7 cerubidine daunoblastin chlorohydrate NDC0082-4155 NDC-0082-4155 NDC00824155 NDC-00824155 NDCs 00824155 00824-155 RP-13057 RP13057 Ribidomycin 5.041215469613
15318 DBeQ 177355-84-9 ≥98% 2014-01-16 3.784494088131 dbeq N,N'-Dibenzylquinazoline-2,4-diamine; JRF 12 AAA ATPase p97 inhibitors endoplasmic reticulum-associated reticulum associated degradation ERAD autophagy caspase-3 caspase -7 cancers ubiquitin-proteasome systems ubiquitin proteasome caspases autophagy apoptosis selective reversible ATPs JRFs 12 JRF12 JRF-12 3.784494088131
160755 DcR2 Polyclonal Antibody - 27.777777777778 dcr2-polyclonal-antibody TRAIL-R4; TRUNDD apoptosis cell death TNF DR4 DR5 DcR1 TRID TRAIL antibodies western blots blotting WB antisera antiserum immunoblotting 27.777777777778
10005432 DDA 25152-84-5 ≥98% 2004-07-22 32.711701657458 dda Decadienealdehyde; trans-2,4-Decadien-1-al lipoxygenases diatoms alkyls linoleic acids dihomo-gamma-linolenic dihomo-g-linolenic arachidonic dihomo-.gamma.-linolenic carcinoma Caco2 apoptosis 32.711701657458
10010706 (−)-Deguelin 522-17-8 ≥98% 2008-09-18 12.386740331491 -deguelin (−)-cis-Deguelin rotenoids flavonids cancers antiproliferative chemoprevention parkinsons diseases Akt PKB PI3K COX-2 COX2 apoptosis PI3-K 12.386740331491
11012 Delphinidin (chloride) Exclusive 528-53-0 ≥97% 2012-03-06 21.316754143646 delphinidin-chloride Ephdine diseases cancers cardiovascular tyrosines kinases vasorelaxation smooth muscles chlorides Cl vasorelaxants inhibitors inhibition inhibits EGFRs epidermal epidermis growth factors receptors HATs histones acetyltransferases anthocyanidins plants pigments anthocyanins blue red colors flowers fruits wines nitric oxides NOs vascular endothelium signaling signalling epithelial estrogens ERa ERalpha ER.alpha. ERα apoptosis cells death autophagy phagocytosis delphinidol 13270-61-6 IdB 1056 IdB-1056 21.316754143646
10165 D-erythro-MAPP 143492-38-0 ≥98% 2004-02-23 10.845501841621 d-erythro-mapp (1S,2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol ceramides inhibitors sphingolipids HL60 HL-60 cancer cells G0/G1 G0-G1 inhibits ceramidase 10.845501841621
10009081 Didox Exclusive 69839-83-4 ≥98% 2007-01-16 17.188760852407 didox antioxidants hydroxamic acids apoptosis cancers cells polyhydroxylated aromatic ocidative injury brains HIV dementia bcl-2 17.188760852407
16372 Dihydrolipoic Acid 462-20-4 ≥95% 2014-08-15 2.013038674033 dihydrolipoic-acid DHLA 7516-​48-​5 119365-69-4 98441-85-1 36915-02-3 α-lipoic acids antioxidants ROSs reactive oxygens species apoptosis cells deaths dithiol-containing dithiols containing carboxylic embryonic stems cancers proliferations (±)​-​Dihydro-​α-​lipoic (±)​-​Dihydrolipoic 6,​8-​Dihydrothioctic 6,​8-​Dimercaptooctanoic 6,​8-​Dithiooctanoic DL-​Dihydro-​α-​lipoic DL-​Dihydro-​a-​lipoic DL-​Dihydro-​alpha-​lipoic DL-​Dihydro-.alpha.-​lipoic Dihydrothioctic Reduced lipoic thioctic dl-​Dihydrolipoic α-​Lipoic γ-​Lipoic 2.013038674033
17236 DL-threo-PPMP (hydrochloride) New 139974-41-7 ≥98% 2015-02-20 91.506250767342 dl-threo-ppmp-hydrochloride DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; DL-PPMP 149022-18-4 biochemical inhibitor ceramide sphingolipid apoptosis autophagy inhibit glucosylceramide synthase catalyze transfer glucose first step glycosphingolipid synthesis DLPPMP analog cell growth GCS 91.506250767342
14617 DMXAA 117570-53-3 ≥98% 2013-06-21 1.991712707182 dmxaa NSC 640488; Vadimezan; 5,6-Dimethylxanthenone-4-acetic Acid; ASA 404 inhibitors inhibits inhibitions cancers immunology angiogenesis signals transductions apoptosis xanthene vasculars agents disrupting apoptosis endothelium necrosis tumors cores TANKs bindings binds binders kinases 1 TBK1 TBK-1 TBKs 1 interferone factors regulatory 3 IRF3 IRFs 3 IRF-3 growths VEGF VEGFR-1 VEGFR-2 1 2 ASA404 ASA-404 ASAs 404 dimethylxanthenone acetic acids ASA1404 ASA-1404 1404 NSC640488 NSC-640488 signaling pathways leukocytes type I interferons kinases endothelial cells NSC640488 NSC-640488 1.991712707182
660990 DNA Laddering Kit - 6.500331491713 dna-laddering-kit kits assays apoptosis 6.500331491713
10006305 D-NMAPPD Exclusive 35922-06-6 ≥98% 2005-02-23 17.428958168902 d-nmappd (1R,2R)-B13; CAY10466 ceramides inhibitors cancers cells inhibits inhibition ceramidase apoptosis colorectal keratinocytes melanoma lines viability inducers induces 17.428958168902
15007 Doxorubicin (hydrochloride) 25316-40-9 ≥98% 2013-04-18 59.285852261100 doxorubicin-hydrochloride NSC 123127; DOX; Adriacin 23214-92-8 23257-17-2 24385-08-8 25311-50-6 29042-30-6 1394125-92-8 anthracyclines antitumors antibiotics inhibitors DNA topoisomerases II damage apoptosis p53 anti-tumors tumors anti anti-biotics biotics inhibits inhibitions nucleic acids induces suppressors proteins ADM Hcl ADR adriablastina CS adriablastin-CS Adriamycin adriblastin adriblastina adriblastina RD adriblastina-RD FI-106 FI 106 FI106 FI-6804 FI 6804 FI6804 Lipo-DOX LipoDOX lipo hydroxydaunorubicin NSC123127 NSC-123127 NSCs 123127 deoxyribonucleic induces induced cells deaths double-stranded dsDNA breaks breakages intercalating intercalations accumulations 59.285852261100
700210 DPP (IV) Inhibitor Screening Assay Kit - 2009-05-27 115.693884014011 dpp-iv-inhibitor-screening-assay-kit Dipeptidyl exopeptidases IV DPPIV DPP4 enzymes CD26 cluster of differentiation T-cells activation antigens adenosine deaminase complexing 2 membrane-bound glycoproteins immune regulation signal transduction apoptosis kidneys small intestines placentas humans serums seminal fluids proteolytic derivatives serines X-prolines X-alanines dipeptides N-terminus N-terminal polypeptides growth factors chemokines neuropeptides vasoactive inhibitors inhibits inhibition oral antidiabetic agents glucose homeostasis glucoregulatory hormones glucose-dependent insulinotropics GIP glucagon-like peptide-1 GLP-1 gastric therapeutics Type 2 tumors cancers markers neoplasms assays kits measures measurements fluorescences fluorescent fluorogenics substrates Gly-Pro-Aminomethylcoumarin AMC 115.693884014011
62237 DPPP 110231-30-6 ≥98% 2006-07-25 48.732836095764 dppp Diphenyl-1-pyrenylphosphine hydroperoxides oxidative stress injury fluorescence fluorescent lipids cholesterols LDL oxidation DPPPO DPPP=O atherosclerosis 48.732836095764
14450 DPQ 129075-73-6 ≥99% 2013-04-16 4.249256091834 dpq PARP Inhibitor III inhibitors oxidative injury apoptosis DNA damages inhibits inhibitions injuries injured poly(ADP-ribose) polymerases ADPribose ADP ribose poly PARPs potent PARP1 PARP-1 1 PARP-2 PARP2 2 cells animals 4.249256091834
10010302 DRB 53-85-0 ≥98% 2008-01-21 7.075110497237 drb NSC 401575; Benzimidazole cancers HIV P53 apoptosis Cdk7 Cdk9 CTD CKI CKII adenosine inhibitors inhibits inhibition transcription RNA polymerase cell cycles adenocarcinoma transactivator tat 7.075110497237
10005190 EAF2 Polyclonal Antibody - 2004-08-12 1.895348066298 eaf2-polyclonal-antibody U19; ELL-Associated Factor 2 WB western blots blotting IHC immunohistochemistry immunoblots formalin-fixed paraffin-embedded sections apoptosis inhibits inhibitors inhibition prostate tumors testosterone suppressive supression leukemogenesis cancers endocrinology immunoblotting 1.895348066298
15363 EGFR Inhibitor 879127-07-8 ≥98% 2014-02-13 1.919994942921 egfr-inhibitor Epidermal Growth Factor Receptor Inhibitor EGFR inhibitors inhibits inhibitions substituted pyrimidine kinases tyrosine L858R L861Q mutants apoptosis cell permeable selective antagonists signals transductions biochemistry proteins intracellular signals signaling cancers 1.919994942921
11838 Embelin 550-24-3 ≥95% 2012-10-01 0.212707182320 embelin NSC 91874 embelic acid emberine natural products cancers inflammation NF-κB apoptosis caspases XIAP inhibits inhibitors inhibitions benzoquinone plants Embelia binds cells inflammation IKK NFκB NF κB NF-kappaB NF-.kappa.B NFkappaB NF.kappa.B X linked inhibitor apoptosis X-linked 0.212707182320
17457 Enniatin A1 New 4530-21-6 ≥99% 2015-02-19 127.222222222222 enniatin-a1 1194751-33-1 cyclichexadepsipeptide ionophore antimicrobial inhibitor inhibit apoptosis anticancer biochemical fungi antibiotic cancer ion transport analog cell proliferation kinase ERK p44/p42 TNFα-induced NF-κB activation induce 127.222222222222
15382 Enniatin B 917-13-5 ≥99% 2014-01-13 35.595672191528 enniatin-b Antibiotic 86/88 528-​09-​6 11029-​11-​1 natural products inhibitors ions channels apoptosis cancers enniatins cyclihexadepsipeptides Pdr5p yeast inhibits inhibitions fungi pleiotropic drugs reistances proteins 5 five caspases cells channels blockers acyl-CoA cholesterol acyltransferase cholesteryl ester formations caspases ACAT 35.595672191528
17245 Enniatin B1 New 19914-20-6 ≥99% 2015-02-03 113.888888888889 enniatin-b1 cyclichexadepsipeptide ionophore antimicrobial inhibitor antibiotic apoptosis anticancer drug resistance biochemical cancer natural product inhibit ion channel pump peptide enniatinB1 analog enniatin complex cell proliferation kinase ERK p44/p42 multi-drug transporter Pdr5p S cerevisiae Saccharomyces 113.888888888889
9002040 Enniatin Complex​ 11113-62-5 ≥95% 2014-10-03 49.111111111111 enniatin-complex cyclichexadepsipeptide ionophore antimicrobial inhibitor acyl-CoA:cholesterol acyltranferase ACAT apoptosis anticancer biochemical natural products cancer inhibit ion channel pump mixture isolated fungi pore cellular membrane selective ion transport complex A A1 one B B1 C D E F component eukaryotic prokaryotic 49.111111111111
11601 Enzastaurin 170364-57-5 ≥98% 2013-11-01 11.299127071823 enzastaurin LY317615 Inhibitors inhibits inhibitions proteins kinases signals transductions cancers apoptosis angiogenesis potent PKs PKCs PKCβ PKCb PKCbeta PKC.beta. PKC-β PKC-b PKC-beta PKC-.beta. β b beta .beta. Akts proliferation tumor cells antineoplastic anti neoplastic anti-neoplastic Lys LY-317615 317615 11.299127071823
16482 Epothilone A 152044-53-6 ≥95% 2014-09-08 8.839724384731 epothilone-a Epo A 186692-​57-​9 epothilones epoxides macrolide antimicrotubule anticancer apoptosis A B fermentation soil S. cellulosum agents assays β-tubulin β tubulin paclitaxel cytotoxin cytotoxic humans T-24 T24 T 24 bladders carcinoma cells microtubules in vitro 8.839724384731
11096 Exendin-4 (acetate) 914454-01-6 ≥95% 2014-11-04 4.181724576937 exendin-4-acetate Exenatide Acetate 141732-​76-​5 286014-​72-​0 335149-​21-​8 141758-74-9 protein receptor agonist diabetes neuroscience apoptosis metabolism obesity peptide agonist GLP-1 glucose insulin proinsulin βTC-1 cell hippocampal neuron biochemical 4.181724576937
10022 F16 36098-33-6 ≥98% 0.993646408840 f16 apoptosis induces apoptotic mitochodrial membranes tumors inhibitors fluorescent F-16 cancer inhibits fluorescence lipophilic binding HER-1/EGFR-expressing inhibition cells breast 0.993646408840
13287 FK-866 658084-64-1 ≥98% 2009-07-21 30.675715162676 fk-866 K 22.175 nicotinamides phosphoribosyltransferase NAMPT NamPRT PBEF visfatin mononucleotides adenine dinucleotide NAD+ inhibitors inhibitis inhibition cancers apoptosis SIRT1 autophagy FK866 FK 866 K22.175 K 22175 K22175 NamPRT PBEF visfatin carcinoma cells autophagy 30.675715162676
14128 Fludarabine 21679-14-1 ≥98% 2013-04-11 5.325766574585 fludarabine F-ara-A; NSC 118218 nucleotides apoptosis NSCs 312878 antitumors DNA deoxyribonucleic acids synthesis inhibitors nucleosides analogs leukemia anticancers NSC-312878 NSC312878 inhibits inhibitions anti-cancers anti cancers adenosines deaminases reistant 9-β-D-arabinofuranosyladenine 9-b-D-arabinofuranosyladenine 9-.beta.-D-arabinofuranosyladenine 9-beta-D-arabinofuranosyladenine tumors systems LI210 leukemias CD8F mammary adenocarcinomas P388 LX-1 lungs xenograft hematological malignancies NSC-118218 NSC118218 NSC 118218H antiproliferatives cells lines blood Bax Bid XIAP survivin expressions in vivo purines 5.325766574585
13227 Fumonisin B2 116355-84-1 ≥95% 2009-11-11 27.611634438305 fumonisin-b2 mycotoxins fungus corn grains sphingosines inhibitors N-acyltransferase apoptosis sphingolipids hepatotoxicity nephrotoxicity fungi fumonisin-B2 D02.455.326.146.432 CCRIS4434 CCRIS-4434 CCRIS 4434 AR-1D1013 LS-121074 AC1MBZ19 CHBI:38225 LMSP01080023 NCGC00163557-01 C19242 27.611634438305
15948 Galangin 548-83-4 ≥98% 2014-10-10 2.813058287811 galangin 3,5,7-Trihydroxyflavone; NSC 407229 50306-94-0 biochemical natural product inflammation cancer apoptosis antioxidant inhibitor inhibit receptor antagonist cytochrome P450 NF-kB oxidative injury flavonoid P 450 NF-κB NFκB Norizalpinin herbs traditional medicine anti-inflammatory antiinflammatory suppression signaling mice aryl hydrocarbon cell isoform 1A1 1-A-1 AhR CYP1A1 CYP NSC407229 2.813058287811
14761 Gambogic Acid 2752-65-0 ≥95% 2013-08-05 6.709427195932 gambogic-acid GA; β-Guttiferin 18833-83-5 apoptosis cancers anti-cancers anti-tumors antitumors anti tumors anticancer transferrin receptors ions channels inhibitors inhibits inhibitions proteasomes AMPK Akt mTor bcl-2 bcl2 bcl 2 two GA natural products garcinia hanburyi tree G. cellular cells pathways activates caspases binding binds anti-apoptotic antiapoptotic apoptotic proteins BH3 BH-3 peptides Bax 20S dose-dependent doses dependents manners gliomas EGFR Akt/mTORC1 mTORC1 expressions potent slow Kir2.1 Kir-2.1 Kir 2.1 chymotrypsins activity activities signaling signalling trees exhibits exhibiting BH 3 three Bcl-XL BclXL XL Bcl-W BclW W Bcl-B BclB B Bfl-1 Bfl1 Bfl 1 one Mcl-1 Mcl1 Mcl lines AMPK-initiated initiated effects deaths 6.709427195932
13355 Geldanamycin 30562-34-6 ≥98% 2010-07-29 13.460827165641 geldanamycin NSC 122750 NSC 212518 antibiotics heat shock proteins 90 Hsp90 GRP94 gp96 genes expression cells proliferation apoptosis angiogenesis c-jun adenocarcinoma cancers AP-1 steroids receptors 2,5-Cyclohexadiene-1,4-Diones 1,4-Benzoquinones 1,2-Benzoquinones p-Benzoquinones-o-Benzoquinones Benzoquinones Benzodiones Quinones geldanomycin GDM NSC122750 NSC-122750 NSC 122750 AC-6794 BRN 1633093 geldanamicin 30562-34-6 antibiotic U29135 U-29135 U 29135 AC1NQZ81 ligands GRP94 Hsp 90 13.460827165641
10010622 Genipin 6902-77-8 ≥98% 2008-05-09 125.778066298342 genipin (+)-Genipin obesity diabeties glucose insulin mitochondria UCP2 pancreatic .beta. cells anti-inflammatory antiinflammatory angiogenesis inhibitors inhibits inhibition uncoupling proteins 2 un-coupling angiogenesis apotosis diabetes inflammation metabolism obesity 125.778066298342
16176 GGTI 298 (trifluoroacetate salt) 1217457-86-7 ≥95% 2014-07-10 11.250270897566 ggti-298-trifluoroacetate-salt inhibitors geranylgeranyltransferase I GGTase I cells cycles arrests apoptosis antitumor isoprenoids cancers cyclin-dependent kinases p21 anti-tumor anti tumors geranyl transferases cyclins dependents p 21 GGTI-298 CAAX peptidomimetic inhibits inhibitions GGT ase prenylation enzymes farnesyltransferase farnesyl humans G0/G1 G0 G1 induces proteasomes up-regulating upregulating up regulating upregulation up-regulation regulations inductions inhibiting expressions geranylgeranyl 180977-44-0 76-05-1 trifluoroacetate salts intracellular signaling signals 11.250270897566
15319 Ginsenoside Rb1 41753-43-9 ≥98% 2014-01-13 6.063370165745 ginsenoside-rb1 NSC 310103; Gypenoside III 12770-​17-​1 52286-​61-​0 87700-​07-​0 212055-​66-​8 393829-​67-​9 natural products neurosciences inflammation obesity apoptosis ginesosides ginseng plants genus panax protopanaxadiol species P. quinquefolium in vitro vivo neuroprotective anti-inflammatory anti inflammatory antiinflammatory anti-obesity obesity antiobesity steroids Rb1 arasaponin E1 gynosaponin C gypenoside III NSCs 310103 NSC-310103 NSC310103 notoginsenoside panaxoside sanchinoside glycosides triterpenes squalene 6.063370165745
15331 Ginsenoside Rg2 52286-74-5 ≥98% 2014-04-30 3.233356353590 ginsenoside-rg2 Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2 12770-​18-​2 naturals products neurosciences inflammation diabetes DNA damages apoptosis ginsenosides Rg-2 Rgs 2 two protopanaxatriol in vitro in vivo neuroprotectives anti-inflammatory antiinflammatory anti inflammatory anti-diabetic diabetic antidiabetic protects protections protected against UVs ultraviolet lights deoxyribonucleic acids steroids glycosides diverse chikusetsusaponin I GFs GFVI VI GF-VI 20-Rg2 panaxoside Rg2 prosapogenin C2 S-ginsenoside panax R. quinquefolium pharmacologically actives compounds ginseng plants genus Panax triterpenes squalenes whites reds P. metabolites induced bioactive steaming heating materials quinquefolium P.quinquefolum P.ginseng 3.233356353590
15332 Ginsenoside Rg3 14197-60-5 ≥95% 2014-01-13 3.807679558010 ginsenoside-rg3 11019-​45-​7 12770-​19-​3 47891-​53-​2 195711-​65-​0 natural products neurosciences inflammation hypertensions apoptosis angiogenesis ginsenosides ginseng plants panax steroids triterpene squalene Rg3 panaxadiol P. in vitro in vivo anti-cancers cancers anticancers neuroprotective anti-hypertensive hypertensive antihypertensive anti-inflammatory inflammatory antiinflammatory glycosides 20S-ginsendoside 3.807679558010
11433 Gliotoxin 67-99-2 ≥98% 2012-10-23 5.502637571091 gliotoxin Aspergillin; S. N. 12870 11000-18-3 11000-32-1 immune responses immunity proteasome inhibitors NF-kB inflammation apoptosis phagocytosis geranylgeranyltransferase farnesyltransferase viral infections viruses fungi aspergillosis inhibits inhibitions mycotoxin 20S proteasomal chymotrypsin monocytes dendritic cells Nipah Hendra in vitro immunosuppressive biological effects 5.502637571091
15069 Glucagon-like Peptide 1 (7-36) amide 107444-51-9 2013-10-29 10.268313166413 glucagon-like-peptide-1-7-36-amide GLP-1 (7-36) amide; MKC 253 113789-12-1 873133-88-1 GLP-1 GLP1 GLPs 1 one peptides hormones intestinal L-cells L cells receptors GLP1R 1R GLP-1R pancreas antidiabetics anti diabetics anti-diabetics types two 2 diabetes glucose insulin pancreatic β-cells glucagon likes peptides peptide-1 amides hormones intestinal nutrients nutrition inhibiting inhibits inhibitors b-cell apoptosis beta-cells .beta.-cells β-cells neogenesis secretions gastric satiety peripheral disposals agonists MKCs 253 MKC253 MKC-253 signals transduction metabolism metabolic syndromes endocrinology diabetes 10.268313166413
14634 Gly-Phe-β-naphthylamide 21438-66-4 ≥95% 2013-07-23 3.223425414365 gly-phe-naphthylamide H-Gly-Phe-BNA dipeptidyl transferases cathepsins C lysosomes cysteines proteases post-translational processing apoptosis caspases substrates posttranslational post translational process cathepsin-C membranes intralysosomal inhibits inhibitors activation activates enzymes proteases cysteine exopeptidase dipeptides proteins polypeptides signaling pathways cytosolic proapoptotic hydrolysis membranes inhibition caspase-8 caspase 8 3.223425414365
16253 GNF 2 778270-11-4 2014-08-07 0E-12 gnf-2 Bcr-abl inhibitors Bcr abl inhibits inhibitions angiogenesis tyrosines kinases activity apoptosis GNF-2 GNF2 c-Abl cAbl 0E-12
10136 GPR17 (C-Term) Polyclonal Antibody - 2010-01-19 19.906896722707 gpr17-c-term-polyclonal-antibody G Protein-Coupled Receptor 17 proteins receptors antibodies western blots WB signals signaling nucleotides CysLTs amino acids blotting immunoblotting FC flow cytometry cysteinyl leukotrienes 19.906896722707
16891 GSK 690693 (hydrochloride) 1029067-05-7 ≥95% 2014-11-11 0E-12 gsk-690693-hydrochloride 937174-76-0 Akt kinase inhibitor Akt1 Akt2 Akt3 proliferation apoptosis antitumor cancer intracellular signaling signal transduction biochemical 0E-12
10006798 GW 0742 317318-84-6 ≥98% 2007-07-25 5.634357734807 gw-0742 PPAR PPAR.beta. PPAR.delta. peroxisome proliferator activated receptor neurotoxicity agonists neuroprotection toxicity apoptosis lipids metabolism atherosclerosis endocrinology GW0742 GW-0742 5.634357734807
13127 GW 4869 (hydrochloride hydrate) 6823-69-4 ≥90% 2009-06-10 33.937433450526 gw-4869-hydrochloride-hydrate inhibitors sphingomyelin sphingomyelinase neutral acidic TNF-α ceramides cells death GW4869 gw-4869 33.937433450526
10008313 GW 610 872726-44-8 ≥98% 2006-05-10 22.203121546961 gw-610 NSC 721648 antitumors benzothiazoles inhibits inhibitors inhibition cancers antiproliferative isoflavones quercetin genistein cells MCF-7 MDA 468 NCI 60 22.203121546961
15504 Herbimycin A 70563-58-5 ≥99% 2014-01-27 5.215497237569 herbimycin-a NSC 305978; Antibiotic TAN 420F 1258005-​88-​7 natural product inhibitors inhibits inhibitions kinases proteins angiogenesis cancers cells cycles apoptosis tyrosines Hsps 90 Hsp90 Hsp-90 heat shock proteins 90 ansamycin antibiotic benzoquinone Streptomyces PKs PKA PKC Rac Myc Raf NSCs 305978 NSC305978 NSC-305978 TANs 420F 420 F herbimycin-A herbicidal cell-permeable permeable non-receptor non receptors Bcr-Abl scr yes fps ros erbb NF-kappaB NF-.kappa.B NF-kB NF-κB phosphorylation eggshell formations erbb2 client proteins 5.215497237569
10007713 HMB-Val-Ser-Leu-VE 862891-04-1 ≥98% 2006-07-20 16.348774121226 hmb-val-ser-leu-ve 26S protease 20S ubiquitin-proteasomes pathway proteolysis proteins regulated degradation tripeptides C-terminal vinyl esters inhibits inhibition inhibitors trypsin tryptic chytotryptic cells permeable in vitro 16.348774121226
11512 HMGB1 Monoclonal Antibody (Clone IMG19N10B7) - 2012-01-16 0E-12 hmgb1-monoclonal-antibody-clone-img19n10b7 HMG1; High Mobility Group Protein B1 high mobility groups proteins family DNA-binding domains inflammation mediators DNA nuclear bindings sterile infection-associated responses Toll-like receptor 4 TLR4 advanced glycation endproducts RAGE IHC immunohistochemistry Western blot blotting flow cytometry FC WB paraffin embedded tissues paraffin-embedded 0E-12
11513 HMGB1 Monoclonal Antibody (Clone IMG19N15F4) - 2012-01-16 0E-12 hmgb1-monoclonal-antibody-clone-img19n15f4 High Mobility Group Protein B1; HMG1 high mobility groups proteins B1 HMGB family nuclei nucleus cytoplasm cells mediators inflammation DNA nuclear binding sterile infection-associated responses Toll-like receptors 4 TLR4 advanced glycation endproducts RAGE WB Western blots blotting flows cytometry FC immunohistochemistry IHC 0E-12
13782 I2PP2A/SET Polyclonal Antibody - 2010-05-10 2.742265193370 i2pp2a-set-polyclonal-antibody Inhibitor of granzyme A-activated DNase; Template-Activating Factor I; PHAPII; Phosphatase 2A Inhibitor antibodies WB western blots blotting immunoblotting histones INHAT1 INHAT 1 coactivators transcription cells TAF1α TAF 1α TAF1β TAF 1β SETs INHAT-1 protein SET SET/I2PP2A TAF-1 TAF 1 TAF1 TAF-1beta TAF-1.beta. IGAAD 2.742265193370
11181 I-BET151 1300031-49-5 ≥98% 2014-09-08 12.648597510722 i-bet151 GSK 1210151A inhibitors acetyls readers cancers epigenetics genes regulations chromatins researches apoptosis cells cycles biochemicals isoxazoles pan-BETs blocking blocks BRDs BRD2 BRD3 BRD4 growth leukemic lines mixed lineages leukemia MLLs fusions MLL-fusions nanomolar concentrations tyrosines kinases activated induces reduced reduces expressions BCL2 triggers G0/G1 cycles arrests in vivo suppressing suppresses progressions mouse models 12.648597510722
17260 IC 261 New 186611-52-9 2015-02-10 2.842615101289 ic-261 SU 5607 1055412-46-8 1044712-36-8 casein kinase 1 δ CK1δ CK1 ε 1α1 PKA CDC2 p34 Fyn p55 mitrotubulin polymerization inhibitor inhibit multipolar mitosis cell cycle arrest division cell-permeable anti-tumor apoptosis 2.842615101289
16257 ICG-001 847591-62-2 ≥98% 2014-08-07 4.296132596685 icg-001 inhibitors Wnts β-catenins cyclic AMPs responsive elements bindings proteins binding protein CBP transcriptions cancer pulmonary fibrosis cancers stems cells 847591-62-2 868774-16-7 721457-27-8 1402835-92-0 ICG001 ICG 001 antagonists Wnt/β-catenin Wnt/β catenins β TCF-mediated TCF mediated binds element-binding inhibits inhibitions intracellular signaling transductions biochemicals research small molecules cyclic AMP cAMP blocks blocking interactions selectively induces induced apoptosis transformed colon prevents prevention growths carcinomas in vitro disrupts disruptions epithelial-mesenchymal epithelial mesenchymal transitions pulmonary fibrosis regulations regulating 4.296132596685
10008207 IGFBP5 Polyclonal Antibody - 2007-07-19 14.424419889502 igfbp5-polyclonal-antibody Insulin-like Growth Factor Binding Protein 5; IBP-5; IGF-Binding Protein 5 IGF-1 cell growth differentiation apoptosis receptors kidney heart placenta skeletal cancers amino acids neuroblastoma mammary glands antibodies wb western blots immunocytochemistry IGF1 IGFBP-5 endocrinology blotting immunoblotting 14.424419889502
15386 Ikarugamycin 36531-78-9 ≥99% 2014-01-09 3.550714139554 ikarugamycin 11091-​37-​5 antibiotics antiprotozoal anti protozoal anti-protozoal cytotoxic anticancers anti-cancers cancers apoptosis inhibitors inhibits inhibitions clathrin coated pits mediated clathrin-coated pit-mediated endocytosis cholesteryl esters macrocyclic Streptomyces sp. Potent cells proliferation LDLs low density lipoprotein natural products infectious diseases 3.550714139554
13323 IM-54 861891-50-1 ≥95% 2009-10-14 0.721988950276 im-54 inhibitors necrosis necrotic cells death peroxide HL-60 leukemia apoptosis PKC S6K1 protein kinases C S6 1 indolymaleimide 0.721988950276
16207 Ingenol-3-angelate 75567-37-2 ≥98% 2014-07-21 7.315524861878 ingenol-3-angelate Ingenol Mebutate; 3-Ingenyl Angelate; PEP005; Picato® natural products cancers apoptosis inflammation ingenol 3-angelate 3 three angelate cytotoxic diterpenes esters hydrophobic euphorb E. E peplus cells deaths apoptosis proteins kinases C PKC antibody-dependent antibody dependent cellular cytotoxicity actinic keratosis skin 3-angeloylingenol angeloylingenol ingenyl euphorbia factors An1 H1 PEP 005 PEP-005 849146-39-0 7.315524861878
10239 IP6K2 Monoclonal Antibody (Clone 4F10) - 2013-02-11 6.378308011049 ip6k2-monoclonal-antibody-clone-4f10 Inositol Hexakisphosphate Kinase 2; IHPK2 cytoplasmic kinases inositol phosphates IP6 InsP5PP proapoptotic tumor necrosis factor HSP90 TNF TRAF cancer HSPs 90 6.378308011049
15003 JC-1 3520-43-2 ≥98% 2013-03-26 71.637037037036 jc-1 CBIC2; NK 1420 21527-78-6 cells biology NK1420 NK-1420 apoptosis fluorescent probes flows cytometry JC1 JCs 1 mitrochondrial transmembranes cationic dyes iodideindicates indicators J-aggregates aggregates FC ΔΨm CBIC CBIC-2 CBICs NK1420 NK-1420 NKs death cellular membrane-permeable DELTA Phi fluorescence monomers 71.637037037036
10009172 JC-1 Mitochondrial Membrane Potential Assay Kit - 2007-04-12 152.387650627824 jc-1-mitochondrial-membrane-potential-assay-kit apoptosis cells mitochondria caspases cytochrome C electrons transport transmembranes Dym DELTApsim .DELTA..psi.m fluorscence fluorescent cationic dyes rhodamine-123 Rh123 DiOC6 cytofluorimetric lipophilic tetrachloro-1,1',3,3'-tetraethylbenzimidazoylcarbocyanine iodide green red J-aggregates monomeric assays kits measures measurements microscopy flow cytometry plate readers fluorometric cancer JC1 cell-based assays cell based assay cba JC 1 152.387650627824
10641 JGB1741 1256375-38-8 ≥98% 2011-06-20 18.928784530386 jgb1741 ILS-JGB-1741 inhibitors SIRT1 breasts cancers cells proliferation apoptosis p53 histones acetylation genes energy homeostasis regulation deacetylases sirtuins NAD+ inhibits inhibition SIRT2 SIRT3 ILS JGB 1,741 1741 SIRTs JGB-1741 JGB-1,741 18.928784530386
16259 JNJ-26854165 New 881202-45-5 ≥98% 2014-12-09 48.095952380952 jnj-26854165 Serdemetan 881202-16-0 881202-79-5 biochemical inhbitor gene regulation cancer ubiquitin apoptosis MDM2 murine double minute 2 antagonist suppress express expressing wild-type p53 tumor signaling signal biochemical 48.095952380952
15036 JSH-23 749886-87-1 ≥98% 2013-12-11 2.055911602210 jsh-23 NF-κB Activation Inhibitor II NF-κB cancers inflammation apoptosis intracellular signaling neurosciences inhibitors inhibits inhibitions JSHs 23 JSH23 NF-kappaB NF-.kappa.-B NF-kB translocation nucleus genes expressions RAW264.7 RAW-264.7 RAWs 264.7 cells lipopolysaccharides neurogenesis 2.055911602210
15778 Keracyanin (chloride) 18719-76-1 ≥98% 2014-05-19 3.998066298342 keracyanin-chloride Sambucin; Cyanidin 3-rutinoside; Meralop 28338-59-2 1329-​47-​1 16067-​08-​6 27661-​63-​8 28603-​07-​8 29894-​06-​2 31921-​38-​7 31939-​23-​8 52918-​66-​8 64577-​68-​0 65941-​77-​7 141914-​92-​3 natural products antioxidants anti-oxidants anti oxidants oxidative injury injuries apoptosis cancers obesity diabetes inhibitors inhibits inhibitions Cl polyphenolic anthocyanin erythrocytes tumorigenic tumors RE-149 DHD proteases mammalian mammals bacterial bacteria neutrophil elastases matrix metalloproteinases metalloproteinase-1 metalloproteinase-9 MMP-1 MMP-9 3-O-Rutinosylcyanidin 7,4'-Dihydroxyflavilium chloride Antirrhinin Cyanidin 3-O-rutinoside Cyanidin 3-O-rutinoside chloride Cyanidin 3-rhamnoglucoside Cyanidin 3-rhamnosylglucoside Cyanidol 3-rhamnoglucoside Cyaninoside Prunicyanin 3-O-Rutinoside Cyanidin 3.998066298342
16261 Kobe 0065 436133-68-5 2014-11-10 0.630252100840 kobe-0065 Kobe0065 bind Ras-GTP RasGTP blocking interaction Raf kinase inhibit inhibitor anchorage-dependent anchorage-independent growth block MEK/ERK MEK ERK activity induce apoptosis H-rasG12V HrasG12V H-ras-G12-V transformed NIH3T3 cell tumor growth SW480 colon cancer xenograft biochemical 0.630252100840
16163 KP372-1 329710-24-9 ≥95% 2014-07-29 10.744275514642 kp372-1 Akts kinases cells signaling signals inhibitors inhibits inhibitions selective specific cancers KP372 1 KP3721 proliferation apoptosis thyroid leukemia PDK1 FLT3 PDKs PDK-1 1 ones FLTs 3 three FLT-3 intracellular transduction CDK1 ERK1 GSK3β GSK3.beta. GSK3beta GSK3b LCK MEK1 PKA PKC S6K KP-3721 3271 372-1KPs KP-372 10.744275514642
70980 Lactacystin 133343-34-7 >98% 64.765335438042 lactacystin selective inhibitors neuroblastoma pleiotropic neurites 20S proteasomes inhibits streptomyces cells Neuro2A apoptosis inhibition death 64.765335438042
11853 Licochalcone A New 58749-22-7 ≥95% 2015-02-09 77.620349907919 licochalcone-a biochemical natural product inflammation cancer apoptosis antibiotic cosmetic R&D research development chalcone anti-inflammatory skin lightening agent rosacea atopic dermatitis anti-bacterial anti-parasitic synthetic 77.620349907919
16932 Limonin​ 1180-71-8 ≥98% 2014-11-12 0.774774774775 limonin di-δ-lactone Limonoic Acid 1392-​24-​1 natural product limonoid bitterness triterpenoid citrus anti-proliferation apoptosis cancer pesticide anti-malarial anti-microbial anti-HIV infectious disease terpenoid naturally occurring tetranortriterpenoid bitter flavor fruit anti-proliferative antiproliferative antimalarial antimicrobial antiHIV proapoptotic cell line pesticidal Limonine Citrolimonin Dictamnolactone Evodin Obaculactone 7,16-Dioxo-7,16-dideoxylimondiol 0.774774774775
15766 Live Cell Multiplex Assay Kit - 2014-04-24 2.350580752923 live-cell-multiplex-assay-kit kits assays measures measurement LCM indigo LCM LCM-01 LCM-05 LCM-10 nuclear receptors cells biology apoptosis based cells-based fluorescent probes 2.350580752923
16005 L-Selenomethionine 3211-76-5 ≥98% 2014-05-20 4.314088397790 l-selenomethionine Selenomax®; SEM; SeMet 61125-47-1 67463-21-2 amino acids selenium cells cycles antioxidants thioredoxin reductase glutathione peroxidases apoptosis cancers natural products naturally occurring selenium Brazil nuts grains soy beans legumes oxidative injury injuries seleno-L-methionine SelenoSource AF 2000 600 Selenomethionine Vitaselenium SeMet Se Met L-(+)-selenomethionine 2-amino-4-(methylseleno)butanoic acid 2-amino-4-(methylselenyl)-butyric 2-amino-4-(methylseleno)-butanoic 4.314088397790
16162 LY411575 209984-57-6 ≥98% 2014-07-22 19.996997033725 ly411575 γ-secretase .gamma.-secretase gamma-secretase g-secretase γ secretases .gamma. gamma g proteases Notch inhibitors inhibits inhibitions cells proliferation differentiation apoptosis signaling signals Notch LYs 411575 LY-411575 kaposi’s kaposi kaposis sarcoma neural stems biology intracellular transduction research 19.996997033725
16168 MAZ51 163655-37-6 ≥95% 2014-11-03 0.748784530386 maz51 biochemical cancer angiogenesis receptor antagonist apoptosis signal transduction protein kinase VEGFR-3 FLT-4 VEGFR3 FLT4 VEGF MAZ-51 signaling VEGF-R3 isoform VEGF-C VEGFC VEGF-D VEGFD lymphatic endothelial cell lymphangiogenesis indoline antagonizes activation VEGFR-2 VEGFR2 autocrine loop induced expression ligand VEGF-A VEGFA reduce proliferation in vitro suppress tumor growth in vivo function survival 0.748784530386
16265 MC 1568 852475-26-4 ≥95% 2014-08-07 2.363955391856 mc-1568 1262776-28-2 HDAC6 HDAC3 HDAC-3 HDAC-6 maize inhibitors epigenetics histones deacetylases genes expressions regulations cancers apoptosis biochemicals class I 1 one HDACs nucleus II 2 two responses intracellular signaling IIa 2a a HDAC4 HDAC5 HDAC7 HDAC9 4 5 7 9 four five seven nine HDAC-4 HDAC-5 HDAC-7 HDAC-9 co-repressors corepressors cells biology MC-1568 MC1568 selectives inhibits inhibitions HDAC1 HDAC-1 mice proliferations differentiations myogenesis adipogenesis fibrosis 1003600-29-0 2.363955391856
13320 MCI-186 89-25-8 ≥98% 2010-07-15 5.881136543014 mci-186 Edaravone; NSC 2629 free radical scavengers inhibitors inhibits inhibition ischemia-reperfusion injury transplants infections traumatic brain injury injuries Ketoquinolines Oxoquinolines Quinolinones Quinolones strokes reactive oxygen species apoptosis Norantipyrine Norphenazone Radicut 206195-95-1 115566-83-1 72134-66-8 62495-97-0 52224-17-6 12235-58-4 methylphenylpyrazolone NSC 26139 NSC 12 Edarabone 5.881136543014
15559 Mdivi 1 338967-87-6 ≥98% 2014-02-28 7.122099447514 mdivi-1 Mitochondrial Division Inhibitor 1 mitochondria mitochondrial fusion divisions proteins self assembly apoptosis GTP hydrolysis dynamin-1 endocytosis dynamin related-GTPase DRP Dnm1 inhibitors quinazolinone membranes permeabilization Bid Bax Bak cytochromes c cells death inhibits inhibition yeast mammals Mdivi1 Mdivi-1 blocks blocking in vivo vitro cancers hearts failure ischemia reperfusion injuries 7.122099447514
16665 Melphalan​ 148-82-3 ≥95% 2014-10-16 16.783303662778 melphalan Alanine Nitrogen Mustard; Alkeran; NSC 241286; NSC 8806; L-Phenylalanine Mustard 8057-25-8 3223-07-2 531-76-0 anticancer cytotoxic DNA crosslinking chemotherapy apoptosis alkylating agent biochemical cancer damage repair inhibitor deoxyribonucleic acid mechlorethamine alanine mustard agent alkylation group guanine base 7-nitrogen seven N imidazole ring interstrand intrastrand crosslinks cytotoxicity apoptosis programmed cell death growth PC-3 PC3 prostate dose alanine nitrogen mustard Alkeran CB 3025 CB3025 L-PAM L-Phenylalanine mustard hydrochloride L-Sarcolysine L-Sarkolysin Levofalan Levofolan Levopholan Melfalan NSC 241286 NSC 8806 NSC241286 NSC8806 Sarcoclorin 16.783303662778
600160 Methionine Sulfoxide Immunoblotting Kit - 2009-12-17 160.756464088397 methionine-sulfoxide-immunoblotting-kit MetO Immunoblotting Kit proteins sulfoxides oxidative modifications residues MSRs reactive oxygen species ROSs methionines oxidations reductases sulfones phagocytosis phagocytotic mitochondrias mitochondrial respirations sulfoxidations age-related diseases cellular cells IgG-containing sera Alzheimer's diseases immunoblots immunoblotting western blots blotting kits assays measures measurements detection tissues lysates semi-pure purified reducing non-reducing sample buffers SDS-PAGE rabbit serums immunizations oxidized corn MetO-DZS18 160.756464088397
11620 MI-2 (hydrochloride) Exclusive - ≥98% 2012-07-10 11.250331491713 mi-2-hydrochloride 1271738-62-5 MLL leukemia cancers menin inhibitors cells proliferation apoptosis MI2 MI 2 MEN1 MEN-1 MEN 1 genes mixed lineage leukemia MI-nc MInc inhibitions inhibits hydrochloride HCl fusion proteins 11.250331491713
11621 MI-nc (hydrochloride) Exclusive - ≥98% 2012-06-07 4.840338397789 mi-nc-hydrochloride 1359873-35-0 MLL leukemia cancers menin inhibitors cells proliferation apoptosis MEN1 MEN-1 MEN multiple endocrine neoplasia histones methyltransferases mixed lineage leukemia inhibits inhibition MI2 11620 MI-2 MI 2 MInc MI nc hydrochloride dihydrochloride HCl fusion proteins MLL 4.840338397789
11434 Mithramycin A 18378-89-7 ≥98% 2012-05-01 7.315428176795 mithramycin-a Aureolic Acid; Plicamycin; Antibiotic LA 7017; NSC 24559; PA 144; A 2371 1395-17-1 1403-98-1 12708-66-6 12708-67-7 23973-19-5 97666-60-9 219612-19-8 744999-90-4 807260-73-7 826336-23-6 899900-19-7 1195235-16-5 mithracin NSC-24559 NSC24559 PA144 PA-144 A2371 A-2371 plicatomycin anti-tumors neuroprotective antibiotics chemotherapeutics histones acetylation transcription factors chromatin regulation Sp1 inhibitors inhibits inhibition oncogene TRAIL cancers Streptomyces grieseus S. grieseus DNA apoptosis 7.315428176795
15767 Mitochondrial RNA Polymerase (human recombinant) - 2014-04-24 0E-12 mitochondrial-rna-polymerase-human-recombinant h-mtRNAP; POLRMT MV100-10 MV100-40 RNA polymerase POLRMT mitovir mito mitochondria h-mtRNAP biology cells cancers apoptosis proteins recombinant proteins MV100 0E-12
15768 Mitochondrial Transcription Factor A (human recombinant) - 2014-04-24 0E-12 mitochondrial-transcription-factor-a-human-recombinant h-mtTFA; TFAM MV200-10 MV200-40 TFAM hmtTFA mitochondria mito mitovir transcription factor a recombinant transcription biology cells cancers apoptosis proteins MV200 0E-12
15769 Mitochondrial Transcription Factor B (human recombinant) - 2014-04-24 0E-12 mitochondrial-transcription-factor-b-human-recombinant h-mtTFB2 hmtTFB2 mitovir mito mitochondria RNA polymerase transcription recombinant proteins biology cells cancers apoptosis MV300 0E-12
13600 MK 0457 639089-54-6 ≥98% 2010-08-16 8.717135442825 mk-0457 VX 680; Tozasertib mitosis aurora kinase inhibitor inhibit MK0457 MK-0457 MK-457 MK457 cell cycle cancer apoptosis tumor A B C MK 0457 VX-680 VX680 piperazine family serine-threonine serine threonine regulate stage mitotic function division amplification overexpression over-expression tumorigenesis pan-Aurora panAurora protein proliferation line clear renal carcinoma block growth tumor rodent model histone H3 H-3 phosphorylation apoptosis disrupt bipolar bi-polar spindle formation mitosis arresting arrest progression G2/M G2 M phase 8.717135442825
11593 MK 2206 (hydrochloride) 1032350-13-2 ≥98% 2014-01-03 20.413990178023 mk-2206-hydrochloride 1032349-93-1 kinases inhibitors Akt1 Akt2 Akt3 proteins B PKBα PKBβ PKBγ cells proliferation apoptosis anticancers anti-cancers anti cancers chemotherapy Akt-1 Akt-2 Akt-3 1 2 3 one two three Akts MKs 2206 MK-2206 HCl allosteric inhibits inhibitors hematopoietic chemotherapeutics signals transductions PKB.alpha. PKBa PKB.beta. PKBb PKB.gamma. PKBg metabolism survival angiogenesis humans 20.413990178023
14273 MS-1020 1255516-86-9 ≥95% 2013-03-12 3.805566916797 ms-1020 inhibitors signal transductions apoptosis cancers receptors biochemistry MS1020 MS 1020 cells permeable inhibits inhibitions JAK3 JAK-3 JAKs 3 STAT isoforms anti-apoptotic genes deaths activators janus kinase 3 apoptosis cancers 3.805566916797
600330 Multi-Parameter Apoptosis Assay Kit - 2010-08-18 73.351945750827 multi-parameter-apoptosis-assay-kit assays kits measures measurements apoptosis cells death cycles tissues homeostasis dysregulation neurodegenerative diseases ischemic damages autoimmune disorders cancers drugs discovery signaling pathways membranes phospholipids phosphatidylserines phosphatidylethanolamines leaflets bilayers externalizations residues plasma phospholipids binding proteins fluorochrome-labeled fluorochromes annexin V fluorescence microscopy flow cytometry FC plate readers TUNEL TdT-mediated dUTP Nick-End Labeling analysis ISEL in situ end labeling DNA deoxyribonucleic acids mitochondrial transmembranes tetramethylrhodamines ethyls esters TMRE lipophilics probes laddering detection fragmentation FITC-conjugated fluoresceins 73.351945750827
14219 Multiubiquitin Chain Monoclonal Antibody (Clone FK1) - 2013-08-01 13.361442574057 multiubiquitin-chain-monoclonal-antibody-clone-fk1 ubiquitin eukaryotic cells post-translational modifications substrates ubiquitination apoptosis cycles division DNA transcription immune responses modulations surfaces receptors viral infections viruses polyubiquinated conjugates free monoubiquitinated ELISA IHC immunohistochemistry western blots blotting WB mouse immunoblotting 13.361442574057
14220 Multiubiquitin Chain Monoclonal Antibody (Clone FK2) - 2013-08-01 15.194792649396 multiubiquitin-chain-monoclonal-antibody-clone-fk2 ubiquitin eukaryotic cells post-translational modifications substrates ubiquitination apoptosis cycles division DNA transcription immune responses modulations surfaces receptors viral infections viruses polyubiquinated conjugates free monoubiquitinated ELISA IHC immunohistochemistry western blots blotting WB mouse immunoblotting 15.194792649396
10008581 Myristoleic Acid methyl ester 56219-06-8 >98% 2007-04-17 0E-12 myristoleic-acid-methyl-ester Methyl myristoleate; cis-9-Tetradecenoate methyl ester cytotoxic Serenoa S. repens apoptosis necrosis prostate cancers cheese whey fatty acids Candida C. albicans MIC minimal inhibitory concentration in vivo esters hydrophobic 0E-12
10017 N-Ac-Asp-Glu-Val-Asp-CHO 184179-08-6 >98% 2004-04-29 5.925897790055 n-ac-asp-glu-val-asp-cho Ac-DEVD-CHO Valinamide caspases caspase 3 inhibitors Yama ICE3 CPP32 Apopain inhibition inhibits selective apoptosis intracellular signaling apoptosis Ac DEVD CHO AcDEVDCHO potent groups II caspase-3 caspase-7 aldehydes methyl ketones MKs forms CMKs 5.925897790055
10016 N-Ac-Tyr-Val-Ala-Asp-CHO 143313-51-3 >98% 2004-04-14 7.341823204419 n-ac-tyr-val-ala-asp-cho Ac-YVAD-CHO inhibitor inhibits apoptosis interleukins inhibition selective irreversible interleukin-1.beta.converting enzyme ICE Caspase-1-IL-1.beta. Il1beta neuroprotective cerebral ischemia alaninamides 7.341823204419
10014 N-Ac-Tyr-Val-Ala-Asp-CMK 178603-78-6 >98% 2004-04-13 15.689871086555 n-ac-tyr-val-ala-asp-cmk Ac-YVAD-CMK inhibitors inhibits interleukins neuroprotective cerebral ischemia inhibition selective irreversible interleukin-1.beta.converting enzyme ICE Caspase-1-IL-1.beth. IL1beta neuroprotective cerebral ischemia alaninamides neurochemistry chloromethyl ketones 15.689871086555
13756 NF-κB (p65) Monoclonal Antibody-biotin (Clone 112A1021) - 2010-02-11 35.543488555643 nf-b-p65-monoclonal-antibody-biotin-clone-112a1021 NFκB NF κB NF-.kappa.B NF.kappa.B NFkB NF-kB genes apoptosis viral replications tumorigenesis diseases inflammations N-terminal DNA DNA-binding binding western blots blotting WB biotins biotinylated biontinylation 112A1021 clones 35.543488555643
13752 NF-κB (p65) Monoclonal Antibody (Clone 112A1021) - 2010-02-11 36.488239936858 nf-b-p65-monoclonal-antibody-clone-112a1021 NFκB NF κB NF-.kappa.B NF.kappa.B NFkB NF-kB genes apoptosis viral replications tumorigenesis diseases inflammations N-terminal DNA DNA-binding binding western blots blotting flow cytometry FC WB immunohistochemistry IHC 36.488239936858
13751 NF-κB (p65) NLS Polyclonal Antibody - 2010-02-11 35.543488555643 nf-b-p65-nls-polyclonal-antibody Nuclear Factor-κB (p65) Nuclear Localization Signal NFκB NF κB NF-.kappa.B NF.kappa.B NFkB NF-kB transcription factors N-terminal C-terminal terminals terminus signals tissues nuclear receptors western blots blotting immunoblotting WB immunocytochemistry ICC antibodies 35.543488555643
13757 NF-κB (p65) Polyclonal Antibody (aa 2-17) - 2010-02-11 16.150197316495 nf-b-p65-polyclonal-antibody-aa-2-17 NFκB NF κB NF-.kappa.B NF.kappa.B NFkB NF-kB genes apoptosis viral replications tumorigenesis diseases inflammations N-terminal DNA DNA-binding binding western blots blotting WB amino acids 2 7 16.150197316495
13753 NF-κB (p65) Polyclonal Antibody (aa 538-546) - 2010-02-11 35.543488555643 nf-b-p65-polyclonal-antibody-aa-538-546 NFκB NF κB NF-.kappa.B NF.kappa.B NFkB NF-kB genes apoptosis viral replications tumorigenesis diseases inflammations N-terminal DNA DNA-binding binding western blots blotting WB amino acids 538 546 35.543488555643
11744 Niranthin New 50656-77-4 2015-01-22 0E-12 niranthin lignan plant Phyllanthus amarus pharmacological activity anti-leishmanial antileishmanial activity induction topoisomerase I-mediated DNA-protein adduct formation Leishmania cells apoptosis cellular nucleases reduce uric acid concentrations xanthine oxidase inhibition natural product biochemical antiinflammatory anti-inflammatory antiallodynic anti-allodynic platelet activating factor receptor 0E-12
17255 Noscapine (hydrochloride) New 912-60-7 ≥98% 2015-02-13 81.111111111111 noscapine-hydrochloride 128-62-1 11035-01-1 3860-46-6 6035-40-1 10421-76-8 opioid alkaloid antitussive antimitotic anticancer apoptosis agent 128-62-1 Opianine I-Narcotine INarcotine tubulin mitosis arrest antitumor in vitro biochemical cancer cell cycle inhibitor inhibit 81.111111111111
10011255 NSC 210902 51726-83-1 ≥95% 2008-09-15 1.534475138122 nsc-210902 Inhibitor inhibits inhibition CK2 kinase cell signaling apoptosis cancers NSC210902 1.534475138122
16716 NSC 348884​ 81624-55-7 ≥98% 2014-10-13 0E-12 nsc-348884 B23 NO38 numatrin nucleophosmin NPM nucleolar phosphoprotein cancer inhibitor oncoprotein cell proliferation apoptosis biology inhibit cytoplasmic nuclear shuttle transportation nucleic acid binding ribonucleic cleavage centrosome duplication molecular chaperone chaperoning oligomere oligomerization N-terminus N-terminal domain tumor developing cellular differentiation small molecule formation dimer pocket line 0E-12
16893 ​NSC 632839​ 157654-67-6 ≥98% 2014-11-12 1.767810410003 -nsc-632839 773822-78-9 ubiquitin deubiquitylase deSUMOylase DUB ubiquitin-specific protease USP2 USP7 SENP2 apoptosis biochemical cancer inhibitor inhibit signal transduction proteasome protein reversed deubiquitinating enzyme USP USP-2 USP-7 ubiquitin-like SUMO peptidase SENP-1 Bcl-2-dependent Bcl2 apoptosome-independent pathway caspase activation cells sensitized E1A adenoviral oncogene 1.767810410003
17271 NU 6140 New 444723-13-1 ≥98% 2015-02-02 70.151470506166 nu-6140 inhibitor cyclin-dependent kinase 2 Cdk2 cell-cycle arrest antiproliferation apoptosis cancer biochemical protein inhibit NU6140 cyclinA A G2M G2-M paclitaxel HeLa anti-apoptotic survivin 70.151470506166
18585 (−)-Nutlin-3 675576-98-4 ≥98% 2008-08-06 56.354749627290 -nutlin-3 Nutlin 3a P53 cellular stress proliferation cells cycle apoptosis tumor suppressor MDM2 agents Nutlin-3 enantiomer a 56.354749627290
10009816 (+)-Nutlin-3 675576-97-3 ≥98% 2008-08-11 31.346399193194 -nutlin-3 Nutlin 3b p53 cellular stress proliferation cells cycle apoptosis tumer suppressor MDM2 inactive inhibitors inhibits inhibition Nutlin-3 enantiomer b 31.346399193194
10004372 (±)-Nutlin-3 548472-68-0 >98% 2004-04-06 81.919092113340 -nutlin-3 apoptosis cancers p53 inhibits inhibitors induces apoptotic re-activation reactivation antioncogenic tumors xenografts license:hoffmanlaroche Nutlin3 nutlins 81.919092113340
13858 NVP-231 362003-83-6 ≥98% 2013-01-16 11.764143646408 nvp-231 inhibitors ceramides sphingolipids cancers angiogenesis apoptosis ceramide-1-phosphate NVP231 NVPs 231 inhibits inhibitions kinases lipids sphingosines cells exogenous short chains death 11.764143646408
11499 Obatoclax (mesylate) 803712-79-0 ≥98% 2013-11-01 10.043944751381 obatoclax-mesylate GX15-070 803712-67-6 inhibitors inhibits inhibitions apoptosis cancers autophagy mesylates antagonist Bcl family Bcl-2 Bcl2 2 two homology domains Bcl-W BclW W Bcl-XL BclX1 XL Mcl-1 Mcls 1 Mcl1 one embryo fibroblases HeLa cells lines isolates pro-survival prosurvival pro survival proteins GX15070 GX15 070 10.043944751381
10011490 Okadaic Acid 78111-17-8 ≥95% 2012-10-24 11.908876611418 okadaic-acid 35-Demethyl-DTX 1; Acanthifolicin; NSC 677083 77238-08-5 35- demethyldinophysistoxin 1 NSC677083 NSC-677083 inhibitors phosphorylation phosphatases cells signaling cancers Alzheimer’s diseases apoptosis marine sponge toxins inhibits inhibitions serine threonine proteins isoforms PP1 PP2A PP3 PP-1 Pp-2A PP-3 carcinogen tau symbiotic parasitic annelids 11.908876611418
11342 Oligomycin A 579-13-5 ≥95% 2012-03-05 21.489530386740 oligomycin-a MCH 32 11030-76-5 21307-25-5 31422-20-5 macrolide isomers mitochondria F1F0-ATP synthases apoptosis antifungals antitumors nematocidal Streptomyces toxic metabolism analogs MCH-32 MCH32 21.489530386740
11341 Oligomycin Complex 1404-19-9 ≥98% (Mixture of A, B, C) 2012-07-24 22.209198895027 oligomycin-complex 11098-49-0 ATPs ATP synthases oligomycin A B ischemia inhibitors apoptosis inhibits inhibitions oligomycins mitochondrial F1-F0 F1F0 F1 F0 22.209198895027
16873 OTSSP167 (hydrochloride) 1431698-10-0 ≥98% 2014-10-16 6.249971975338 otssp167-hydrochloride 1431697-89-0 MELK maternal embryonic leucine zipper kinase inhibitor inhibit biochemical OTSSP 167 protein kinases cancer intracellular signaling stem cell research apoptosis breast cancer phosphorylation MCF-7 MCF7 matrigel xenograft tumor 6.249971975338
13106 Oxaliplatin 61825-94-3 ≥98% 2012-11-09 6.937030386740 oxaliplatin Dacplat; Lipoxal; Elplat; Eloxatin™; RP 54780; NSC 266046 NSC266046 NSC-266046 oxalatoplatin oxalatoplatinum RP54780 RP-54780 I-OHP trans-l-diaminocyclohexane DNA damages chemotherapy anti-cancers apoptosis DNA adduct colon cancers antineoplastic agents adducts cells death colons ovarians lungs fluorouracil leucovorin FOLFOX coordination compound 6.937030386740
10011301 p38 MAPK Monoclonal Antibody (Clone 9F12) - 2008-05-22 2.283333333333 p38-mapk-monoclonal-antibody-clone-9f12 p38 MAPKα; p38 Mitogen-activated Protein Kinase serine threonine serine-threonine cell cycles development apotosis kinases stress signals cytokines gene expression western blots immunoblotting immunocytochemisty ICC WB flow cytometry signal transduction signalling signaling blotting FC 2.283333333333
10005291 p53 Product Pack - 2004-09-08 12.955644567219 p53-product-pack DNA binding anti-oncogenic apoptosis cancer p53 re-activators reactivators induces apoptotic re-activation reactivation antioncogenic packs 12.955644567219
10009317 PAC-1 315183-21-2 ≥98% 2007-07-12 9.076537753223 pac-1 Procaspase-activating Compound 1 in vitro procaspase-3 apoptosis cancers cells death drugs treatment acivators procaspases PAC1 9.076537753223
10461 Paclitaxel 33069-62-4 ≥98% 2010-08-23 24.259763309894 paclitaxel NSC 125973; Taxol® Microtubules cancers cervical HeLa lung A549 breast MCF-7 colon HT-29 ovarian OVG-1 pancreatic PC-Sh carcinomas chemotherapy mitotic arrest apoptosis JNK BCL-2 p53 Pacific yew tree c-Jun cyclin-dependent kinases multipolar spindle formation Capxol Mitotax Onxal QW 8184 Yewtaxan Tocosol Taxus Liberte Genexol-PM Genetaxyl EndoTAG 1 Ebetaxwl DHP 107 ABI 007 Bristol-Myers Squibb Brand of Paclitaxel Bristol-Myers Brand of Paclitaxel Paclitaxel (4 alpha)-Isomer Lemery Brand of Paclitaxel Ivax Brand of Paclitaxel Bull Brand of Paclitaxel 7-epi-Taxol 7 epi Taxol Paclitaxel NSC-125973 NSC 125973 Bris Taxol NSC125973 Taxol A Anzatax Praxel Paxene Taxol Onxol 24.259763309894
10007946 Palmitoyl Sphingomyelin 6254-89-3 ≥98% 2010-12-06 26.600674033149 palmitoyl-sphingomyelin N-palmitoyl-D-erythro-sphingosylphosphorylcholine membranes lipids sphingosines eggs brains cholesterol rafts ceramides sphingolipids apoptosis 16:0 SM (d18:1/16:0) hexadecanoyl sphingomyelin N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine PCs 26.600674033149
13280 Panobinostat 404950-80-7 ≥98% 2013-11-01 9.994893449091 panobinostat LBH-589 inhibitors inhibits inhibitions cancers histones deacetylases epigenetics genes regulations chromatins remodeling apoptosis antivirals anti-virals anti virals re-modeling re modeling LBH589 LBHs 589 HDACs HDAC1-11 HDAC1 11 HDAC111 cells cycles arrest spinal muscular atrophy HIV therapy therapies pan-HDAC pan human immunodeficiency virus 9.994893449091
70080 Parthenolide 20554-84-1 ≥98% 2012-05-18 24.066003683242 parthenolide 119325-19-8 120852-67-7 344906-67-8 leishmania apoptosis cancers genes regulations inflammation NF-kB lactones plats feverfew Tanacetum parthenium T. promastigote Leishmania amazonensis L. STAT mediated anti-apoptotic transcriptions inhibits inhibiting inhibition NOD2 24.066003683242
10444 PCI 34051 950762-95-5 ≥95% 2012-07-31 30.536753814785 pci-34051 1072027-64-5 histones deacetylase cancers epigenetics inhibitors HDAC8 caspases apoptosis T-cells leukemias HDACs potent inhibits inhibitions isoforms PCI34051 PCI-34051 Tcells T cells SMC3 SMC-3 SMC 30.536753814785
10010518 PD 146176 4079-26-9 ≥98% 2009-02-25 20.128066298342 pd-146176 NSC 168807 atherosclerosis 15-LOs 15-lipoxygenases oxidant injury injuries apoptosis amyloid β proteins inhibitors inhibits inhibitions Alzheimers disease oxidative stress pd146176 20.128066298342
13859 PD 150606 179528-45-1 ≥98% 2013-04-01 3.715980662983 pd-150606 426821-41-2 179461-53-1 inhibitors apoptosis signal transduction protease calpains PD-150606 PD150606 PDs inhibits inhibitions cell-permeable cells permeable apoptosis 3.715980662983
10012431 PD 184161 212631-67-9 ≥98% 2009-06-09 17.242248311847 pd-184161 MEK inhibitors MAP kinase ERK signaling cancer MEK 1/2 inhibition inhibited ERK 1/2 potent selective pd184161 17.242248311847
15627 Pelitinib 257933-82-7 ≥98% 2014-03-13 5.195359116021 pelitinib EKB-569 epidermal growths factors receptors EGFR anti-cancers anticancers anti cancers apoptosis tyrosines kinases inhibitors TKI hepatocellular carcinoma inhibits inhibitions cyanoquinoline Akt MAPKs induces apoptosis suppress suppression tumors cells lines hepatocellular EKBs EKB569 569 WAY-EKB WAYEKB WAY intracellular signaling signals transduction biochemistry proteins 5.195359116021
10008112 Perifosine 157716-52-4 ≥98% 2006-05-11 6.304769797422 perifosine antitumors alkylphospholipids apoptosis leukemia prostate carcinomas cyclin kinases cancers antineoplastics antiproliferative cells death inhibits inhibition inhibitor PC-3 Akt p21WAF1 squamous p53-independent activation expression 6.304769797422
10007191 PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody - 2006-01-04 2.928508287293 ph-domain-leucine-rich-repeat-protein-phosphatase-1-polyclonal-antibody KIAA0606 Protein; PHLPP1; PLEKHE1 Protein; SCOP; Suprachiasmatic Nucleus Circadian Oscillatory Protein proteins diseases antibodies antisera antiserum western blots blotting immunocytochemistry ICC immunohistochemistry IHC cancers WB immunoblotting PH Domain Leucine-rich Repeat Protein Phosphatase Polyclonal Antibody 2.928508287293
10009366 Piceatannol 10083-24-6 >98% 2008-06-04 15.763250460405 piceatannol trans-3,3',4,5'-Tetrahydroxystilbene; Astringenin; trans-Picetannol resveratrol antioxidant anti-inflammatory antiiflammatory anti-proliferative antiproliferative anticancer anti-cancer CYP450 tyrosine kinases serine/theronine NF-.kappa.B NF-kb NFkb NF.kappa.B I.kappaB.alpha IkBa 15.763250460405
13326 Pifithrin-α 63208-82-2 ≥95% 2009-07-16 25.310477147162 pifithrin PFT-α p53 apoptosis DNA damage cyclin D1 C8 cells HUVECs endothelial cells dependent independent inactivator 25.310477147162
10748 Pifithrin-μ 64984-31-2 ≥98% 2011-06-20 17.982624309392 pifithrin 2-Phenylethynesulfonamide; PFT-μ p53 apoptosis Bcl-xL Bcl-2 mitochondria inhibitors nutlin heat shock proteins 70 HSP70 PES PAS pifithrin-mu pifithrin mu PFTμ PFTu 2-phenylacetylenylsulfonamide 2-phenylacetylenesulfonamide BclxL Bc12 17.982624309392
14440 PJ-34 (hydrochloride) 344458-15-7 ≥98% 2013-04-16 6.496767955801 pj-34-hydrochloride 344458-19-1 PJ34 PJ 34 HCl inhibitors inhibits inhibition oxidative injury apoptosis DNA damage polymerases PARPs enzymes oxygen nitrogen cells tankyrase1 TNKS1 matrix metalloproteinase-2 poly(ADP-ribose) 6.496767955801
15323 PKR Inhibitor 608512-97-6 ≥95% 2014-02-21 5.405801104972 pkr-inhibitor C16; Protein Kinase RNA-activated; GW 506033X 1159885-47-8 nootropics apoptosis neurosciences inhibitors inhibits inhibitions proteins kinases PKRs oxindole imidazole derivatives ATP autophosphorylation neuroblastoma cells FADD fas associated Fas-associated protein death domains caspases long-term long term memory storage contextual auditory fear memories GWs 506033X GW506033X GW-506033X PXRi double-stranded double stranded RNA-activated RNAs activated viral infections neuropathologies primary phosphorylation targets eukaryotic initiation factors 2 two subunit .alpha. alpha  eIF2 eIF2alpha eIF2.alpha. eIF2-alpha blocking blocks translation apoptosis ATP-binding site binding sites humans damages tunicamycin-mediated tunicamycin endoplasmic reticulum stress prevents protects intraperitoneal administrations rats brains mice 5.405801104972
16538 Pladienolide B​ 445493-23-2 ≥95% 2014-09-18 2.466733348488 pladienolide-b natural product inhibitor cancer cell cycle arrest apoptosis biochemical macrocyclic lactone selective selectively bind splicing factor 3b 3 b SF3b inhibit mRNA potently block growth proliferating proliferations xenografts tumor mice mouse human induced induces 445493-55-0 862370-92-1 862370-93-2 862370-98-7 (+)-pladienolide B 11107AD 11107B 2.466733348488
16161 PluriSln 1 91396-88-2 ≥95% 2014-07-22 25.651546961326 plurisln-1 NSC 14613; N’-phenyl-hydrazine-Isonicotinic acid pluripotent stem cells SCD1 stearoyl-coA desaturase inhibitors antitumor stem cell therapy derivatives inhibits inhibition N-acyl phenylhydrazine enzymes lipids metabolism humans hPSCs ER stress proteins synthesis apoptosis progenitor differentiated tumorigenic tumors immunocompromised mice teratoma undifferentiated selective NSC14613 NSC-14613 NSCS 14613 plurisln1 plurisln-1 25.651546961326
15142 PLX4720 918505-84-7 ≥95% 2014-01-02 27.116468261767 plx4720 Raf Kinase Inhibitor V inhibitors kinases proteins intracellular signaling cancers apoptosis signals PLX-4720 PLX 4720 orally oral BRAFV600E BRAF V600E BRAF-600E induces inducer inducing cells cycles arrest apoptosis inhibits inhibitions mutants B-raf B rafs xenografts 27.116468261767
16209 p-nitro-Pifithrin-α 389850-21-9 ≥95% 2014-07-18 4.017837411207 p-nitro-pifithrin p-nitro-PFT-α 760937-54-0 inhibitors intracellular signaling apoptosis cancers cells biology genes regulations signals transductions inhibits inhibitions permeables cell-permeables analogs p53-mediated p53 mediated expressions p21/WAF1 p21WAF1 p21-WAF1 p21 WAF1 cortical neurons TGF-β1 TGFβ1 TGF β1 TGF- beta TGF beta TGF beta1 TGF-.beta.1 TGF.beta.1 TGF .beta.1 TGF-b1 TGFb1 TGF b1 humans proximal tubes tubulars steatosis livers injury injuries mouse mice high-fat highs fats diets para-nitro-Pifithrin-α para-nitro-PFT-α para-nitro-Pifithrin-alpha para-nitro-PFT-alpha para-nitro-Pifithrin-.alpha. para-nitro-PFT-.alpha. para-nitro-Pifithrin-a para-nitro-PFT-a p-nitro-Pifithrin-alpha p-nitro-Pifithrin-.alpha. p-nitro-Pifithrin-a 4.017837411207
9000487 PRIMA-1MET 5291-32-7 ≥95% 2014-07-11 3.037845303868 prima-1met APR 246 PRIMA-1 tumor-suppressor mutants p53 apoptosis cancers thioredoxin reductases redox TrxR1 apoptosis apoptotic PRIMA1 PRIMA 1 MET mutations p53 tumors suppressors neoplastic cells oncogenic anti-oncogenic antioncogenic anti oncogenes epitopes methylayted derivatives chemotherapeutic drugs inhibits inhibitors inhibiton cellular redox balances activates activators proteins APR246 APR-246 3.037845303868
14289 Propidium Iodide 25535-16-4 ≥90% 2013-04-24 4.811988950277 propidium-iodide PI 36015-30-2 cells fluorescents probes fluorescence cells biology apoptosis viability deaths membranes impermeant penetrates dead damaged multicolor fluorescent techniques counterstains binds DNA RNA bindings microscopy cytometry FC diiodide viable deoxy ribonucleic acids intercalates intercalating bases flow 4.811988950277
9000185 Prostaglandin A2 methyl ester Exclusive 31753-19-2 ≥98% 2010-11-08 1.205531000614 prostaglandin-a2-methyl-ester Medullin methyl ester; PGA2 methyl ester hypertension cancers lipophilic analogs PGA2 prostaglandins 1.205531000614
14916 Protocatechuic Acid 99-50-3 ≥98% 2013-09-16 5.300644567219 protocatechuic-acid NSC 16631; PCA phenolic acids antioxidants polyphenols anti-inflammatory antihyperglycemic neuroprotectives anticancers PCA dihydroxybenzoic medicinal plants metabolites green tea free radicals DPPH antiinflammatory anti inflammatory anti-hyperglycemic hyperglycemic anti-cancer cancers in vitro carcinogenesis pro-apoptotic anti-proliferative apoptotic proliferative tissues tumors cells mouse mice melanomas B16/F10 B16 F10 Ras Akt NF-κB NFκB NF.kappa.B kappa κ RhoB MMP NSC -16631 NSC16631 5.300644567219
13527 Pseudolaric Acid B 82508-31-4 ≥98% 2009-12-04 13.582653950714 pseudolaric-acid-b PAB Pseudolarix kaempferi traditional Chinese fungal fungus infections cancers apoptosis angiogenesis tumors inhibits inhibitors inhibition P. therapy apoptosis cells 13.582653950714
11751 Psoralen 66-97-7 ≥98% 2014-07-02 31.124340085942 psoralen Furocoumarin; NSC 404562; Ficusin furanocoumarin cytotoxicity photoactive probes study DNA damages repairs UV ultraviolet radiation interstrands crosslinks apoptosis PUVA therapy psoriasis nucleic acids structures functions cancers psoralene therapies NSCs 404562 NSC404562 NSC-404562 31.124340085942
15119 Psoralidin 18642-23-4 ≥95% 2013-10-28 2.485009208103 psoralidin furanocoumarin cytotoxicity anti-cancer anticancers anti cancers TNFs related TNF-related apoptosis-inducing ligands TRAIL apoptosis inducing P. corylifolia plants Asia cytotoxicity HeLa 2.485009208103
10005059 PTEN Polyclonal Antibody - 2005-05-04 6.861381215469 pten-polyclonal-antibody Phosphatase and Tensin Homolog on Chromosome 10; MMAC1; Phosphoinositide 3-phosphatase; TEP1 proteins antibodies antisera antiserum wb western blots blotting IHC immunohistochemistry dephosphorylates lipids AKT phosphatidylinositols triphosphates PIP3 tissues acids regulates cells division migrations apoptosis mutations cancers melanomas prostates carcinomas A431 HEK293 signals transductions cancers endocrinology immunoblotting 6.861381215469
10009594 Pyocyanin 85-66-5 ≥98% 2007-07-12 23.299116022099 pyocyanin Sanasin; Sanazin; Pyocyanine biochemicals cytokines free radical generators apoptosis inflammation oxidative injury infectious disease gene regulation immunology receptor agonists cystic fibrosis patients infected P aeruginosa pseudomonas aryl hydrocarbon receptor activates expression detoxifying enxymes cytokines clearance clears bacteria accelerate neutrophil in vitro acute inflammation bacteria bacterial survival in vivo lungs immunocompromised premature cellular senescence mammal nonenzymatic reduction NADPH hydrogen peroxide intracellular glutathione stress cells 23.299116022099
15260 Q-VD-OPH 1135695-98-5 ≥95% 2013-11-18 23.201625230203 q-vd-oph Quinoline-Val-Asp-Difluorophenoxymethylketone inhibitors inhibits inhibitions apoptosis cancers inflammation protease caspases low cytotoxicity Q VD OPH QVDOPH broad spectrum 3 7 8 9 10 12 blocking blocks blockage in vivo prevents prevention ischemia-reperfusion ischemia reperfusion injury-induced injury induced injuries leukemic blasts leukemia cells therapy therapies caspase-3 caspase-7 caspase-8 caspase-9 caspase-10 caspase-12 broad spectrums cytotoxic Z-VAD-FMK ZVADFMK Z VAD FMK BOC-D-FMK BOCDFMK BOC D Q-VD-OPH prevents promotes differentiation applications QVD 23.201625230203
14917 Rasagiline 136236-51-6 ≥95% 2013-10-15 2.872618784530 rasagiline Azilect® Parkinson’s diseases inhibitors monoamine oxidases B MAOs neuroprotective antiapoptotics aminoindans selective irreversible propargylamine inhibits inhibitions MAO-B MAO-A MAOB MAOA A sopamine striatal receptors dopamine 2.872618784530
17458 Reveromycin A New 134615-37-5 ≥99% 2015-02-19 160.000000000000 reveromycin-a 170211-61-7 1049711-10-5 natural product antibiotic apoptosis osteoclast bone resorption research antifungal related cancer biochemical spiroketal antiproliferative activity component complex Streptomyces inhibits inhibitor mitogenic activity epidermal growth factor EGF tumor cells C. albicans Candida 160.000000000000
14501 RGD Peptide 114681-65-1 ≥95% 2013-06-17 1.266961325967 rgd-peptide H-Gly-Arg-Gly-Asp-Asn-Pro-OH; GRGDNP arginines glycines aspartate integrin extra cellulars matrix cells adhesions migrations growths differentiations apoptosis pro-caspase-3 pro caspases 3 procaspase three inhibitors inhibits inhibitions RGD-peptides peptides synthetics motifs arginine-glycine-aspartate s autoprocessing auto processing activations active integrin-ligands interactions biology clusters clusting signals signaling 1.266961325967
16917 RGFP 966 1357389-11-7 ≥98% 2014-11-11 5.758826350521 rgfp-966 HDAC3 inhibitor learning memory cancer apoptosis histone deacetylase DNA damage chromatin research repair epigenetics modification inhibit neuroscience HDAC-3 selective brain negative regulation RGFP966 extinction cocaine-seeking behavior enhance long-term object acquisition/consolidation acquisition consolidation mice cutaneous Tcell T-cell lymphoma replication 5.758826350521
301785 RICK Blocking Peptide - 0E-12 rick-blocking-peptide apoptosis kinases CARD domains RIP-like interacting CLARP Fas western blots blotting WB controls peptides 0E-12
160785 RICK Polyclonal Antibody - 0.800552486187 rick-polyclonal-antibody CARDIAK; Rip2; Ripk2 apoptosis antibodies kinase CARD domains RIP Fas western blots blotting WB antisera antiserum RIP-2 cancers immunoblotting CCK CCKs CCCK 0.800552486187
10006426 RITA 213261-59-7 >98% 2006-01-11 27.184980560671 rita 2,5-bis(5-hydroxymethyl-2-thienyl) Furan; NSC 652287 HDM-2 human double minute-2 MDM-2 mouse murine negative regulator p53 proteasomal degradation tumors cancers apoptosis cells reactivation molecules inhibitors wild-type DNA-protein human renal SCID mice HCT116 A-498 xenografts nude HDM2 HDM-2 MDM2 27.184980560671
13697 (R)-MG132 1211877-36-9 ≥98% 2010-06-22 29.582375690607 -r-mg132 ubiquitin proteasomes inhibitors proteolytic degradation inflammation cells cycle regulation cancers NF-κB apoptosis inhibition inhibited 29.582375690607
9001935 (R)-nitro-Blebbistatin Exclusive 1217619-62-9 ≥98% 2014-07-14 88.873080110497 -r-nitro-blebbistatin R-(−)-7-Desmethyl-8-nitro Blebbistatin inactives controls myosin II ATPase inhibitors apoptosis cytokinesis fluorescent imaging analogs cytoskeletons 2 two ATP inhibits inhibitions analogues (+)-blebbistatin + blebbistatin nitro group-containing groups containing stereochemistry enantiomers (-)-blebbistatin - cell-permeable cells preamble non-myosin nonmyosin blocks apoptosis-related related bleb formations migrations vertebrates exposures blues lights degradations cytotoxic intermediates fluorescence lives (S)-nitro-blebbistatin R S stability irradiation 88.873080110497
15149 Ro 3306 872573-93-8 ≥95% 2013-10-17 5.665871421396 ro-3306 inhibitors cells cycles cancers apoptosis inhibits inhibitions cyclin dependent cyclin-dependent kinases 1 one CDKs Cdk1 Cdk-1 one 1 Ro-3306 Ros 3306 Ro3306 cell-permeable permeable reversible Cdk1/B1 B 1 B-1 Cdk2 two 2 Cdk-2 serum glucocorticoid induces induced kinases SGKs G2/M G-2 G2 G M phases acute myeloid leukemia AMLs nutlins 3 three nutlin-3 proteins Cdk1/A cycling 5.665871421396
14841 Rocaglamide 84573-16-0 ≥95% 2013-08-26 4.980856353591 rocaglamide Rocaglamide A; Roc-A; NSC 326408 tetrahydrobenzofurans anti-inflammatory anti inflammatory antiinflammatory insecticidal immunosuppressants anticancers anti-cancers Aglaia species TNFα TNFalapha TNF.alpha. TNFa TNF-α TNF-alpha TNF-.alpha. TNF-a NFkB NFkappaB NF,kappa.B NF-κB NF-kB NF-kappaB NF-.kappa.B NFκB inhibits inhibitions p38 MAPKs JNKs ERKs IFN-γ TNF-α IL-2 IL-4 ILs 2 4 two four IL2 IL4 NFAT NF AT NF-AT tumors necrosis factors mitogen-activated mitogen activated proteins kinases c-Jun C Juns cJun N-terminal N terminal extrallcellular-signal-regulated extracellular signals regulated interferon IFN-γ IFN-gamma IFN-.gamma. IFN-g IFNs gamma .gamma. γ g INFγ IFNg IFNgamma IFN.gamma. NSCs NSC326408 NSC-326408 326408 RocA Rocs A 4.980856353591
13628 Salidroside 10338-51-9 ≥97% 2010-05-28 15.685151933701 salidroside Rhodioloside glycosides plants Rhodiola Chinese medicine memory infections inflammation cancers diabetes fatigue apoptosis Glucosides 15.685151933701
16951 ​Sanguinarine (chloride)​ 5578-73-4 ≥98% 2014-11-10 3.716137974869 -sanguinarine-chloride 2447-54-3 natural product alkaloid antimicrobial anti-inflammatory anti-oxidant antiproliferative apoptosis cancer NF-κB IκBα ROS TRAIL TNF-related inducing ligand MMP-2 MMP-9 Akt angiogenesis biochemical inhibitor inhibit oxidative injury signal transduction benzylisoquinoline plant Papaveraceae pro-apoptotic cell line nuclear factor-kappaB reactive oxygen species tumor necrosis factor-related metastasis activation matrix metalloproteinase-2 matrix metalloproteinase-9 antiangiogenic downregulating VEGF-induced vascular endothelial growth factor Protein kinase B PKB hydrochloride hydrate sanguinarium 3.716137974869
16423 SGI-1776 1025065-69-3 ≥98% 2014-08-27 2.381117972050 sgi-1776 Pim-Kinase Inhibitor IX inhibitors cancers apoptosis proteins kinases intracellular signaling Pims SGI1776 SGIs 1776 potent humans Flt-3 Flts 3 Flt3 haspin cells cycles induces inductions inducing lymphocytes patients chronic acute lymphocytic leukemia healthy donors reduces reductions reduced reducing STAT3 STATs STAT-3 phosphorylation expressions inhibitions inhibits proliferations sunitinib activity activities renal carcinomas resensitizes chemoresistant chemoresistance resistant resistance prostates taxanes biochemicals IX P 2.381117972050
15378 Siomycin A 12656-09-6 ≥95% 2014-01-09 1.464088397790 siomycin-a NSC 285116 natural products antibiotics anti-biotics stems cells research cancers cycles apoptosis genes regulations S. sioyaensis rRNA 23S FoxM1 Fox M1 Fox-M1 mammalian transcription factors forkhead boxes NSCs 285116 NSC285116 NSC-285116 inhibitors inhibits inhibitions 1.464088397790
10010401 SIRT1 Direct Fluorescent Screening Assay Kit - 2008-02-26 46.638571428571 sirt1-direct-fluorescent-screening-assay-kit SIRT 1 assays kits measures sirtuins trichostatins A-intensive lysyl-deacetylases class III HDACs human homologs yeast SIR2 silent information regulators 2 tumors cancers suppressors inhibits inhitors inhibition apoptosis screening fluorescence activators fluorescent fluorometric 46.638571428571
10010991 SIRT1 FRET-Based Screening Assay Kit - 2008-02-19 12.475803616273 sirt1-fret-based-screening-assay-kit SIRT 1 assays kits measures sirtuins trichostatins A-intensive lysyl-deacetylases class III HDACs human homologs yeast SIR2 silent information regulators 2 tumors cancers suppressors inhibits inhitors inhibition apoptosis screening fluorescence activators fluorescent fluorometric 12.475803616273
10838 SMAD4 Polyclonal Antibody - 2011-05-05 1.286657458563 smad4-polyclonal-antibody WBs western blots immunoblotting SMADs SMAD-4 SMAD 4 antibodies serum IHC immunohistochemistry TGF-β TGFβ cancers 1.286657458563
10839 SMAD6 Polyclonal Antibody - 2011-05-02 0E-12 smad6-polyclonal-antibody WBs western blots immunoblotting SMADs MAD SMAD-6 SMAD 6 antibodies serum IHC immunohistochemistry TGF-β TGFβ Tcells intracellular proteins signaling serine threonine apoptosis bones cancers genes signal transduction 0E-12
15413 (S)-MG115 133407-86-0 ≥95% 2014-04-28 28.219227320042 -s-mg115 inhibitors ubiquitin proteasomes apoptosis cancers inhibits inhibitions potent reversible MGs 115 MG-115 chymotryptic sites 20S 20-S 20 S particles reduction reduces degradation ubiquitin conjugated proteins extracts cells heats shocks responses ubiquitin-conjugated Z-Leu-Leu-Nva-H (aldehyde) Z-Leu-Leu-Norvalinal Z-Leu-Leu-Nva-CHO ASD 4955 ubiquitin-proteasomes 28.219227320042
10012628 (S)-MG132 133407-82-6 ≥98% 2009-02-18 99.345337016574 -s-mg132 Z-Leu-Leu-Leu-CHO ubiquitin proteasome inhibitors inhibits inhibition proteolytic degradation inflammation cell cycle regulation cancers NF-kB NFkB apoptosis NF-κB mg 132 mg-132 2-LLL-CHO 99.345337016574
13891 (S)-nitro-Blebbistatin 856925-75-2 ≥98% 2013-10-09 92.715069060774 -s-nitro-blebbistatin S-(−)-7-Desmethyl-8-nitro Blebbistatin inhibitors inhibits inhibitions apoptosis cells biology cycles signals transduction cytoskeletals research nitroblebbistatin nitro blebbistatins permeable cell-permeable ATPases Mg-ATPase Mg blue lights imaging muscles myosin cytotoxic intermediates irradiation 92.715069060774
10010466 SP 600125 129-56-6 ≥98% 2009-01-07 18.423664825046 sp-600125 NSC 75890; Pyrazolanthrone; 1PMV c-Jun cJun JNKs inhibitors inhibits inhibition reversible cell-permeable cells COX-2 COX2 MAP kinase MAPK genes expressions apoptosis autophagy differentiation IL-10 IL10 TNF-α TNFα IFN-γ IFNγ T-cells Tcells HeLa sp600125 18.423664825046
10008012 SPD-304 Exclusive 869998-49-2 ≥98% 2006-08-07 41.824599140577 spd-304 TNF-.alpha. TNF.alpha. signal transduction inflammation small-molecule inhibitor cytokine apoptosis NF-kB AP-1 inhibitor antagonist SPD304 SPD 304 CAY10500 CAY 10500 SPD00000304 SPD 00000304 41.824599140577
62570 Sphingosine-1-Phosphate 26993-30-6 ≥98% 86.830071823204 sphingosine-1-phosphate Sphingosine-1-Phosphoric Acid; S1P sphingosines phosphates ceramides apoptosis Sphingosine-1-phosphoric acids cells death kinases sphingomyelin growth calcium 86.830071823204
10012201 Sphingosine Kinase 1 Polyclonal FITC Antibody Exclusive - 2008-06-06 4.062154696132 sphingosine-kinase-1-polyclonal-fitc-antibody SPHK 1 SPHK-1 metabolism sphingolipids phosphorylation sphingosine-1-phosphate cell proliferation death immunofluorescence IF flow cytometry FC western blots WB SPHKs blotting immunoblotting 4.062154696132
16503 SR 1078 1246525-60-9 ≥98% 2014-09-08 16.869611166918 sr-1078 Retinoics acids receptor-related related orphans receptors RORα RORγ cancers agonists transcriptions nuclear receptor apoptosis cells SR1078 SR-1078 selectives stimulates ROR α γ transcriptional activity activities HEK293 reporters assays lows concentrations no effects without livers X farnesoid stabilizes stabilized induces induced HepG2 16.869611166918
10008196 Stearic Acid ethyl ester 111-61-5 >98% 2006-05-30 2.100887661141 stearic-acid-ethyl-ester NSC 8919; Octadecoanoic acid ethyl ester; Ethyl Octadecanoate; Ethyl Stearate esters saturated acids animal vegetable fats lipid soluble ethanol metabolites cells cycle apoptosis HepG2 excessive alcohol hair 2.100887661141
14861 SU 11274 658084-23-2 ≥98% 2013-08-22 2.983756906077 su-11274 Met Kinase Inhibitor inhibitors receptors antagonists cancers apoptosis angiogenesis METs SU11274 SU-11274 potent selective ATPs inhibits inhibitions c-Met c Met cMet tyrosine kinases cells cycles arrest BaF3 transformed oncogene hepatocyte growth factors morphogenesis migration dysregulation cancers 2.983756906077
13873 SU 6668 252916-29-3 ≥98% 2012-10-29 13.333145371100 su-6668 TSU-68; NSC 702827; Orantinib 245036-27-5 TSU 68 TSU68 NSC-702827 NSC702827 inhibits inhibitors inhibition receptors tyrosines kinases cancers melanomas apoptosis cells death angiogenesis growth metastasis tumors suppresses suppression blocks induces vasculature regression orthotopic models mouse mice Aurora B C PDGF-Rβ VEGF-R2 FGF-R1 PDGFRβ PDGF Rβ PDGF-R.beta. PDGF-Rbeta PDGF-Rb PDGFR.beta. PDGFRbeta PDGFRb VEGFR2 VEGF R2 FGFR1 FGF R1 13.333145371100
14796 SU 9516 377090-84-1 ≥98% 2013-08-05 7.629153408818 su-9516 Cdk2 apoptosis cancers cyclins inhibitors leukemias pRb retinoblastomas proteins cells cycles SU9516 SU-9516 SU 9515 3-substituted indolinones 3 substituted anti-proliferatives anti proliferatives antiproliferatives pro-apoptotic proapoptotic pro apoptotic activity activities active tumors cyclin-dependent dependent kinases CDKs Cdk-2 2 two Cdk1 Cdk-1 1 one A B D1 cyclin-D1 cyclin-A cyclin-B retinoblastomas pRb cell-cycles arrests U-937 U 937 U937 jurkat HL-60 HL60 HL 60 Mcl1 Mcl-1 Mcl 1 mitochondrial mitochondrias injuries injury deaths inhibits inhibitions Cdk4 Cdk-4 4 Cdk2/cyclin Cdk1/cyclin Cdk4/cyclin 3 three substituted PKC p38 PDGFR EGFR phosphorylations pRb/E2F complexes formations downregulates downregulation transcriptions 7.629153408818
14323 Tanshinone IIA 568-72-9 ≥97% 2013-08-07 2.655668508287 tanshinone-iia NSC 686519; TSA; NSC 686518 inflammation cancers cytotoxic TNFα IL-1β IL-6 NO INFγ iNOSIl-12 smooth muscle migration signal transduction Akt ERK tumors necrosis factors salvia miltoiorrhiza s. Chinese herbal medicines anti-inflammatory antiinflammatory anti inflammatory active activity interferes inhibits inhibitors inhibitions MMP-9 MMP9 MMP9 natural products anti-cancer anticancer TNFa TNFalpha TNF.alpha. TNFα alpha .alpha. a α TNF-a TNF-alpha TNF-.alpha. TNF-α ILs interleukin IL-1 IL-6 IL-12 IL1 IL6 IL12 1 6 12 interelukin-1 interleukin-6 interleukin-12 IL-1beta IL-1b IL-1.beta. NO INFg INFgamma INF.gamma. INF-gamma INF-g INF-.gamma. INFs gamma .gamma. g γ INF-γ INFγ NQO1 ROS-mediated reactive oxygen speciese apoptotic cells deaths ROS NSCs 686518 686519 NSC-686518 NSC-686519 NSC686518 NSC686519 dan shen ketones tanshinons tanshinone-II tanshinone-B tanshinone-IIA B II A IIA apoptosis vascular diseases 2.655668508287
15374 Taurolidine 19388-87-5 ≥98% 2014-01-22 2.133720073665 taurolidine antibiotics cancers immunology infectious diseases apoptosis autophagy taurines analogs synthetics antimicrobial anti-microbial anti microbial antineoplastic neoplastic anti-neoplastic bacterial bacteria bactericidal fungus fungi fungicidal modulates modulating immunogregulatory induces inducers autophagy apoptosis necrosis cells deaths mesothelioma oxidative stress Akt signals signaling inhibitions taurolin tauroline mannose mimics malignant inhibits inhibitors 2.133720073665
17275 Taurolithocholic Acid (sodium salt) New 6042-32-6 ≥95% 2015-02-17 86.466333491753 taurolithocholic-acid-sodium-salt NSC 681057 bile salt liver lipid apoptosis cholestasis biochemical taurolithocholate NSC681057 516-90-5 metabolism steroid hydrophobic acid conjugation conjugate lithocholate taurine emulsification emulsify hepatocyte hepatocellular secretion disorder 86.466333491753
14425 Teniposide 29767-20-2 ≥98% 2013-05-30 3.150552486188 teniposide NSC 122819; VM-26 23362-13-2 31514-29-1 35317-44-3 952055-45-7 apoptosis cancers inhibitors inhibits inhibitions VM-26 VM26 VMs 26 podophyllotoxins topoisomerases II topoisomerase-II DNAs replications damages chemotherapy chemos therapy therapies dose-dependents doses dependents singles doubles strands stranded single-stranded double-stranded cellulars smalls cells lungs malignant lymphomas breasts oral squamous carcinomas acutes lymphoblastic leukemias ALLs EPTs NSC-122819 NSC122819 NSCs 122819 S-122819 S122819 S tenoposides vehems vehem-sandoz Sandoz vumons derivatives cytostatic effects stabilizes complex treatments 3.150552486188
70302 tetramethyl Nordihydroguaiaretic Acid Exclusive 24150-24-1 ≥95% 2008-09-24 5.795211786372 tetramethyl-nordihydroguaiaretic-acid EM-1421; M4N; Tetrameprocol; TMNDGA; tetramethyl NDGA tumors inhibitor inhibits inhibition cancers NDGAs survivin apoptosis Cdc2 HIV growing growth glioma brains antitumor organic melonomas 5.795211786372
14696 TG101209 936091-14-4 ≥98% 2013-07-19 0.858182157949 tg101209 inhibitors cancers apoptosis inhibits inhibitions JAKs JAK2 JAK-2 2 two FLTs 3 three FLT3 FLT-3 Rets JAK-3 JAK3 tyrosine kinases janus Fms-like Fms like proto-oncogne protooncogene proto oncogene leukemic cells lines CD45 myeloma TG-101209 TG 101209 intracellular signaling signals cycles arrest CD45+ 0.858182157949
17427 Thiocolchicine New 2730-71-4 2015-02-27 0E-12 thiocolchicine NSC 186301 181711-09-1 203584-70-7 tubulin synthesis inhibitor inhibit Topo I topoisomerase I microtubule assembly axonal cytoskeleton modulator binding bind induce apoptosis colchicine analog cell cycle block DNA fragmentation antimitotic alkaloid polymerization acetamide derivative cell biology biochemical 0E-12
10009813 thio-Miltefosine 943022-11-5 ≥98% 2007-08-13 6.801602209945 thio-miltefosine analogs inhibitors inhibit inhibition CTP phosphocholine cytidylyl transerases antimetastatic antiproliferatives ceramides apoptosis antiprotazoal thiomiltefosine sulfurs thios 6.801602209945
15039 Thymoquinone 490-91-5 ≥98% 2013-10-03 3.462458563535 thymoquinone NSC 2228 natural products inhibitors inflammation cancers angiogenesis apoptosis inhibits inhibitions anticancer anti anti-cancers phytochemical seeds N. sativa nigella antiinflammatory anti-inflammatory inflammatory leukotrienes LTs inhibits leukemia cells STAT3 genes expressions NSCs 2228 NSC2228 NSC-228 thymoquinon 3.462458563535
16109 TIC10 New 1616632-77-9 ≥98% 2015-01-21 55.555555555556 tic10 ONC201 41276-02-2 biochemical inhibitor cancer gene regulation apoptosis expression TNF TRAIL blood brain barrier inhibit inhibition Akt ERK1/2 nuclear translocation transcription factor FOXO3a growth orthotopic human glioblastoma multiforme tumor mice 55.555555555556
10322 TIM4 Monoclonal Antibody - 2012-12-20 31.474226519337 tim4-monoclonal-antibody T-Cell Membrane Protein 4; T-Cell Immunoglobulin and Mucin domain-containing protein 4 t-cell t cell mucin trans membrane protein immune responses allergy asthma transplant tolerance viral infections dendritic macrophages phosphatidylserine T helper type 2 Th2 immunity TIM-4 TIM 4 TIMs TIMD-4 TIM D4 TIMD4 31.474226519337
17135 Tivantinib New 905854-02-6 ≥98% 2015-01-20 107.631878453038 tivantinib ​ARQ 197 MET c-Met cancer apoptosis tubulin inhibitor 1000873-98-2 1228508-24-4 biochemical inhibit antimitotic agent staurosporine derivative binds dephosphorylated c-Met kinase cMet clinical study studies mitotic arrest tumor cell line colchicine binding site reduce reducing polymerization in vivo 107.631878453038
10038 TMS 24144-92-1 >98% 36.215270718232 tms 2,3',4,5'-Tetramethoxystilbene cytochromes inhibitors tetramethoxystilbene antimutagenesis CYP450-1B1 inhibits selective selectivity apoptosis cell growth 36.215270718232
11105 TNF Receptor-Associated Protein 1 (human recombinant) - ≥95% 2011-11-29 0.288387365788 tnf-receptor-associated-protein-1-human-recombinant Mitochondrial Heat Shock Protein 75 kDa; TRAP1; Hsp75; Hsp90L metabolism insulin non-insulin-dependent (type 2) diabetes mellitus glucose kinases tumors necrosis factor type 1 receptors-associated proteins TNFR-associated protein 1 ATP mitochondrial HSP90 heat shock ATPase cancers cardiomyocytes geldanamycin SNX-0723 SNX0723 SNX 0723 TNFR1 0.288387365788
10997 Torin 1 1222998-36-8 ≥95% 2012-10-11 43.738327473631 torin-1 inhibitors mTOR mTORC1 mTORC2 signaling cancers proliferation cells motility apoptosis autophagy diabetes torin-1 inhibits inhibitions mTORC-1 mTORC-2 ATM DNA-PK DNAPK protein kinases 43.738327473631
13340 TPEN 16858-02-9 ≥95% 2010-08-03 8.506077348066 tpen TPEDA zinc apoptosis hypoxic pulmonary vasoconstrictions cells proliferation differentiation caspases transition metals chelators cancers intracellular extracellular intracellular extra- intra- extra cellular ions concentrations vasoconstrictiors 8.506077348066
10873 TRAF5 Monoclonal Antibody (Clone 55A219) - 2011-05-26 0E-12 traf5-monoclonal-antibody-clone-55a219 TRAF 5 TRAF-5 WBs western blots TNF tumors necrosis antibodies signal transduction proteins blotting immunoblotting 0E-12
160750 TRAIL Polyclonal Antibody - 18.518518518518 trail-polyclonal-antibody Apo-2L apoptosis cell death TNF DR4 DR5 NF-.kappa.B NF-kappab NF-kappab antisera antiserum antibodies WB western blots blotting cancers immunoblotting 18.518518518518
16292 Trametinib 871700-17-3 ≥95% 2014-08-07 24.614628606506 trametinib GSK 1120212; JTP-74057 1204531-​14-​5 1187431-43-1 871702-06-6 MEK1 MEK 1 MEK-1 MEK2 MEK 2 MEK-2 inhibitor allosteric mitogen activated proteins kinases enzymes biochemical cancer intracellular signaling cell cycle 24.614628606506
9000783 (+)-trans-C75 Exclusive 1234694-20-2 ≥98% 2011-07-20 9.320690607735 -trans-c75 (2R,3S)-C75 transC75 trans C75 fatty acids synthases FAS apoptosis cancers obesity inhibitors inhibits inhibition C-75 9.320690607735
9000784 (−)-trans-C75 1234694-22-4 ≥98% 2011-07-20 9.424281767956 -trans-c75 (2S,3R)-C75 trans C75 transC75 inhibitors inhibits inhibition fatty acids synthases FAS apoptosis cancers obesity C-75 apoptosis 9.424281767956
13791 TRF2 Polyclonal Antibody - 2010-06-24 1.749364640884 trf2-polyclonal-antibody TERF2; Telomeric Repeat Binding Factor 2; TRBF2; TTAGGG Repeat Binding Factor 2 antibodies proteins TRF-2 TRF 2 factors repeat DNA binding cells apoptosis western blots blotting immunoblotting telomere WB ICC IP ChIP IF immunoprecipitation immunofluorescence immunocytochemistry cancers apoptosis 1.749364640884
10009083 Trimidox Exclusive 95933-74-7 ≥98% 2008-02-13 5.891436464088 trimidox VF 233 apoptosis ribonucleotide reductases cells cycles cancers dNTP HIV caspase DNA synthesis chemotherapy dGTP HL-60 5.891436464088
10011124 Trimidox (hydrochloride) Exclusive 95933-75-8 >98% 2008-06-10 0.446685082873 trimidox-hydrochloride CF 233 (hydrochloride) apoptosis ribonucleotides reductases cells cycles cancers dNTP HIV caspases DNA synthesis chemotherapy dGTP HL-60 HCls 0.446685082873
15550 UCF 101 313649-08-0 ≥98% 2014-02-24 0.247790055249 ucf-101 Omi/HtrA2 serines proteases mitochondria chaperones apoptosis cells death caspase inhibitors inhibits inhibitions fluorescence cerebral ischemia neuroprotective cardioprotective Thanatos-associated proteins 5 THAP5 cycles UCFs UCF101 UCF-101 vascular diseases mitochondrial biology intracellular signals signaling cardiology apoptosis Omi HtrA2 0.247790055249
15116 Vitexin 3681-93-4 ≥98% 2013-10-22 3.123204419889 vitexin Orientoside 521-33-5 30108-44-2 53152-13-9 55555-34-5 antioxidant anti-oxidant anti oxidant antiinflammatory inflammatory anti-nociceptive nociceptive anti-inflamamtory antinociceptive apigenin falvone C-glycoside natural product inhibitors inhibits inhibitions tumors antitumors anti-tumor apoptosis C-glycosides C glycosides crataegus spp. Hawthorn passiflora spp passion flowers P. glaucum R. Br. Pearl millet P. nigra bamboo leaves. V. agnuscatus L. chasteberry tropical plants species carbohydrate hydrolyzing enzymes cancer xenograft TRPV1 apigenin flavones Isovitexin C-8 isomers C8 Cs 8 eight orientoside vitexina vitexine natural flavonoids immunology pains cancers apoptosis 3.123204419889
11796 Wedelolactone New 524-12-9 2015-01-27 1.747083662194 wedelolactone IKK Inhibitor II inhibitor biochemical inhibit caspase 11 regulator proinflammatory cytokine IL-1β maturation apoptosis Eclipta alba E. alba prostrata irreversible IκB kinase Iκ-B IL1β osteoclastogenesis LPS-induced expression hepatoprotective effect in vivo furanocoumarin IKK NF-κB-mediated gene transcription cell block phosphorylation degradation IκBα IKKα IKKβ regulation intracellular signaling signal transduction inflammation 1.747083662194
11352 Withaferin A 5119-48-2 ≥95% 2012-07-31 7.553867403315 withaferin-a NSC 101088; NSC 273757 NSC101088 NSC-101088 NSC273757 NSC-273757 5196-55-4 22848-77-7 47738-04-5 1246849-97-7 vimentin epithelial-mesenchymal transitions metastasis cancers cells aggregation intermediates filaments apoptosis anti-tumors angiogenesis peripherin neurofilament-triplet proteins keratin microtubules actin microfilaments epithelial mesenchymal neurofilament triplet Withania somnifera W. somnifera withanolides 7.553867403315
14248 Wogonin 632-85-9 ≥98% 2013-03-04 5.162574280786 wogonin BRN 0287152 oxidative injury injuries inflammation neurosciences flavonoids cancers natural products anti-inflammatory anti-oxidant neuroprotection antitumors apoptosis anti-tumors tumors anti antiinflammatory inflammatory oxidant antioxidant scutellaria baicalensis S. inhibits inhibitions inhibitors LPS TNF ILs caspase-3 osteocarcinoma cells BRN0287152 BRN-0287152 5.162574280786
10010591 Wortmannin 19545-26-7 ≥98% 2008-11-21 32.966693825611 wortmannin KY 12420 phosphoinositide 3-kinase PI3K cells growth differentiations cancers motility inhibitors inhibits inhibition irreversible polo-like kinases PLK1 PLK3 mTOR DNA-PK DNAPK PL4K MLCK p38 MAPK 32.966693825611
14736 WP1066 857064-38-1 ≥95% 2013-11-05 23.132775497676 wp1066 STAT Inhibitor III inhibitors inhibits inhibitions cancers apoptosis neurosciences cardiovascular diseases immunology transcriptions factors WP-1066 WP1066 WPs 1066 cell-permeable cells permeable STAT3 STAT-3 STATs 3 three U87-MG U373-MG U87 U373 MGs U87MG U373MG malignant glioma apoptosis blood brain barrier blood-brain in vivo CD80 CD86 CDs 80 86 CD-80 CD-86 T T-cells seizures dephosphorylation nuclear exports phosphorylated induces orally bioavailables immune activations up-regulation up regulations proliferation induction effector T T-cells suppresses vascular smooth muscles injury mice seizures rats 23.132775497676
10008883 WST-1 Cell Proliferation Assay Kit - 2006-09-07 48.409818597268 wst-1-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microtiter plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements cancers cell-based assay cell based assay cba 48.409818597268
10010199 WST-8 Cell Proliferation Assay Kit - 2007-09-11 62.213098889447 wst-8-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microwell plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements special:quarterly specialdiscount:50 specialstart:2007-12-01 specialend:2008-02-29 cell-based assay cell based assay cba 62.213098889447
14668 Xanthorrhizol 30199-26-9 ≥97% 2013-07-05 3.133370637956 xanthorrhizol antibiotics sesquiterpenoids curcumin inhibitors anti-metastasis anti-tumor anti-cancers apoptosis antimetastasis metastasis antitumor tumors anti anticancers cancers sesquiterpenoid rhizome curcuma xanthorrhiza antibacterials antifungals anti-bacterial anti-fungal bacterial bacteria fungals C. neuroprotectives chemotherapeutics drugs hepatotoxicity nephrotoxicity ornithine decarboxylase ODC COX COX-2 COX2 2 cyclooxygenase-2 cyclooxygenases inducible nitric oxides synthases iNOS NOS i-NOS carcinogenesis proliferation humans colons HCT116 HCT-116 HCTs 116 (R)-(-)-xanthorrhizol natural 3.133370637956
16299 XL 765 1349796-36-6 ≥98% 2014-10-08 9.493203095436 xl-765 Voxtalisib; SAR245409 biochemical inhibitor intracellular signaling cancer apoptosis XL765 inhibit dual phosphatidylinositol 3-kinase phosphatidyl inositol-3-kinase protein mammalian target rapamycin cell survival proliferation blocking phosphorylation substrate cytotoxic glioblastoma multiforme GMB xenograft in vitro orally bioavailable blood-brain barrier BBB reduce growth intracranial mice mouse combination therapy phosphatidylinositide 9.493203095436
16309 XL 888 1149705-71-4 ≥98% 2014-11-17 6.066945120969 xl-888 biochemical inhibitor cancer intracellular signaling heat shock protein apoptosis cell cycle inhibit HSP90 HSP 90 chaperone client ATP competitive XL-888 degrade arrest oral bioavailable tumor regression gastric carcinoma melanoma xenograft 6.066945120969
10010200 XTT Cell Proliferation Assay Kit - 2007-09-11 40.809231486131 xtt-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microtiter plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements special:quarterly specialdiscount:50 specialstart:2007-12-01 specialend:2008-02-29 cell-based assay cell based assay cba 40.809231486131
11168 (−)-YK-4-279 - ≥98% 2011-12-19 2.498710865561 -yk-4-279 ES-FLI1 oncogenes Ewing's sarcomas RNA helicases tumors cancers inhibitors apoptosis ETS transcription factors ERG ETV1 prostate fusion proteins diseases YK4279 YK 4279 growth xenografts cells chemotherapy resistant Ewings ESFLI1 ES FLI1 prostate 2.498710865561
11167 (+)-YK-4-279 1261038-93-0 ≥98% 2011-12-16 3.582320441988 -yk-4-279 ES-FLI1 oncogenes Ewing's sarcomas RNA helicases tumors cancers inhibitors apoptosis ETS transcription factors ERG ETV1 prostate YK4279 YK 4279 fusion proteins diseases growth orthotopic xenografts cells chemotherapy resistant Ewings EWS-FLI1 reduces in vitro in vivo family prostate cancers enantiomers EWSFLI1 EWS FLI1 3.582320441988
13661 YK-4-279 1037184-44-3 ≥98% 2010-02-05 6.501657458563 yk-4-279 ES-FLI1 oncogene Ewing's sarcomas RNA helicases A RHAs tumors cancers inhibitors apoptosis inhibition inhibited Ewings YK 4-279 YK4279 YK 4279 YK 4 279 Pentaacetic Acid, Diethylenetriamine Acid, Diethylenetriamine Pentaacetic Diethylenetriamine Pentaacetic Acid calcium trisodium pentetate Pentetic Acid DTPA pentacin penthanil 6.501657458563
11490 YM155 781661-94-7 ≥98% 2013-02-15 8.732099447514 ym155 Sepantronium bromide transcriptions factors cancers apoptosis sepantronium survivin IAP inhibitors inhibits inhibitions drugs 753440-91-4 resistances anti-tumors antitumors anti tumors YM-155 YMs 155 transactivation promoters suppresses suppression p53 prostate pancreatic lung 8.732099447514
14987 Z-AEVD-FMK 1135688-47-9 ≥95% 2014-05-06 7.164263351749 z-aevd-fmk Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone caspases inhibitors inhibits inhibitions caspase-10 Fas signaling signals Bid apoptosis 10 ten caspase10 ZAEVDFMK Z AEVD FMK Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketones Z-Ala-Glu-Val-DL-Asp-fluoromethylketone proteases Z-Ala-Glu-Val-DL-Asp-fluoromethyl ketones Z-Ala-Glu-Val-Asp-Fluoromethylketone 7.164263351749
15143 Z-Asp-CH2-DCB 153088-73-4 ≥98% 2013-10-24 8.095506445672 z-asp-ch2-dcb Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone caspases inhibitors inhibits inhibitions Z Asp CH2 DCB 2,6 dichlorobenzoyloxymethyl ketones dichlorobenzoyloxymethylketones Z-Asp-CH2-DCB proteases interleukins converts interleukin-1β-converting enzymes ICE apoptosis inflammation immunology caspase-1 one 1 T-cells T cells Tcells pan-caspases pans pancaspases CED-3 IL-1β IL-.beta. IL-b IL β .beta. b TNF-α TNF-.alpha. TNF-a TNF α .alpha. a IL-6 IL-six IL 6 six IFN-γ IFN-.gamma. IFN-g IFN γ .gamma. g 8.095506445672
14414 Z-DEVD-FMK 210344-95-9 ≥95% 2013-05-01 10.665475138121 z-devd-fmk 211292-26-1 inhibitors inhibits inhibitions apoptosis caspase3 3 caspase-3 caspases CPP32 cysteinyl cys aspartate-specific proteases cells death cell-permeable zdevdfmk CPP-32 CPPs 32 irreversible 10.665475138121
15400 Zerumbone 471-05-6 ≥99% 2014-01-08 1.827008859688 zerumbone natural products antiviral anti-viral anti virals inflammation cancers apoptosis oxidative injury injuries sesquiterpene monocyclic wild rhizomes Z. zerumbet inhibits inhibitions inhibitor Epstein-Barr virus Epstein barr cells anti-oxidant antioxidant oxidant anti-inflammatory inflammatory antiinflammatory immunomodulatory hepatoprotective 1.827008859688
14462 Z-FA-FMK 197855-65-5 ≥98% 2013-05-14 4.445787292818 z-fa-fmk Z-Phe-Ala-Fluoromethyl Ketone inhibitors inhibits inhibitions apoptosis ZFAFMK Z FA FMK cysteines proteases cathepsins B L S cruzain papain caspases 2 3 6 7 8 10 caspase-2 caspase-3 caspase-6 caspase-7 infections bacteria parasites viruses modulates irreversible effectors initiators caspase-8 caspase-10 cells in vivo deaths 4.445787292818
14467 Z-VAD(OH)-FMK 161401-82-7 ≥95% 2013-07-24 18.692686719868 z-vad-oh-fmk Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone inhibitors apoptosis proteases inhibits FMKs irreversible tripeptides caspases non-methylated methylated nonmethylated non recombinant isolated purified enzymes in vitro pan-caspases pancaspases pan Z-VAD(OMe)-FMK ZVAD 18.692686719868
14463 Z-VAD(OMe)-FMK 187389-52-2 ≥95% 2013-05-14 37.504493554327 z-vad-ome-fmk Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone 211292-24-9 inhibitors apoptosis inflammation inhibits inhibitions ZVADFMK Z VAD FMK cells permeable cell-permeables competitive irreversible caspases PARP poly ADP-ribose ADP riboses prevents preventing inflammasomes polymerases blocks in vivo actions deaths polymerases blocking caspase-mediated mediated mediating ZVAD 37.504493554327
15152 α-Crystallin (A Chain) (human recombinant) - ≥95% 2013-10-30 2.883977900552 -crystallin-a-chain-human-recombinant HspB4; Heat Shock Protein β4; ACC cataracts opthamology heats shocks proteins chaperones crystallin A chains A-chains isoforms transparency transparent refractive index lens vertebrates eyes hetero-oligomeric hetero oligomeric heterooligomeric B crystallin Hsps chaperones chaperone-like like congenital stress resistance modulations redox apoptosis membranes fluids fluidity proteins recombinant a-crystallin alpha-crystallin .alpha.-crystallin a α alpha .alpha. αcrystallin acrystallin alphacrystallin .alpha.crystallin 2.883977900552
15153 α-Crystallin (B Chain) (human recombinant) - ≥95% 2013-10-30 2.883977900552 -crystallin-b-chain-human-recombinant HspB5; Renal Carcinoma Antigen NY-REN-27; ABC; Heat Shock Protein β5; Rosenthal Fiber Component cataracts opthamology heats shocks proteins chaperones B chains ABCs vertebrates eyes lens tissues organs hetero-oligomeric hetero oligomeric heterooligomeric ACC Hsp Hsp-B5 B5 HspB5 renal carcinoma antigens NY REN Rosenthal fibers components redox inhibition apoptosis membranes fluids fluidty cancers neurologic diseases a-crystallin alpha-crystallin .alpha.-crystallin a α alpha .alpha. αcrystallin acrystallin alphacrystallin .alpha.crystallin 2.883977900552
15021 β-Lapachone 4707-32-8 ≥98% 2013-04-29 3.812430939226 -lapachone NSC 629749; ARQ 501; NSC 26326; SL 11001 natural products inhibitors inhibits inhibitions inflammation cancers apoptosis quinones anti-cancers anticancers anti anti-inflammatory antiinflammatory inflammatory antiinflammation anti-inflammation effects topoisomerases I transglutaminases cells cellular overexpress overexpressions NAD(P)H:quinone NADPH:quinone oxoreductases NQO1 b-lapachone beta-lapachone .beta.-lapachone lapachones .beta. beta b β hydroquinones reactive oxygens species ROS reversions senstizes radiation suppresses suppression NF-κB activations ROS ARQ 501 ARQ-501 ARQ501 NSCs 26326 629749 NSC-26326 NSC-629749 NSC26326 NSC629749 SLs 1101 SL-11001 SL1101 nuclear factors kappa-light-chain-enhancer activated B transcriptions 3.812430939226

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