With more than 30 years of experience in the synthesis, purification, and characterization of biochemicals, Cayman Chemical has become a leader in the field of designer drugs by providing high-purity reference standards to federally licensed laboratories and qualified academic research institutions for forensic analysis. Our highly trained staff of chemists provide institutions with solutions to quickly identify and understand the physiological and toxicological properties of new designer drugs. Cayman synthesizes a range of analytical standards including synthetic cannabinoids, cathinones, phenethylamines, amphetamines, indanes, opioids, benzodiazepines, tryptamines, and phytocannabinoids, among many others.
For institutions that rely on highly traceable reference standards for use in quantitative or qualitative testing, Cayman offers synthesized reference materials and certified reference materials accredited to meet ISO/IEC 17025:2017 and ISO 17034:2016 guidelines.
We are committed to ensuring and maintaining quality in all aspects of our reference material production.
Our quality management system is implemented and maintained by trained staff to meet the requirements set forth in ISO/IEC 17025 and ISO 17034. This quality management system is applicable to all staff and activities associated with the manufacture and testing of certified reference standards in our ISO-accredited laboratory.
Each Reference Material (RM) and Certified Reference Material (CRM) is accompanied by an enhanced certificate of analysis (CofA) accredited to ISO standards for testing laboratories and RM producers.
Cayman’s CofA will include a comprehensive table of methods used for the analysis of the neat material, an estimate of uncertainty for each measurement, all relevant analytical data, and a stability assessment.
The CofAs for CRMs additionally report the certified concentration and corrected purity values with the corresponding measurement uncertainties.
ISO/IEC 17025:2017 meets the general requirements for the competence of testing and calibration laboratories. This ISO standard ensures Cayman is carrying out tests and calibrations to the highest degree of quality and reliability while characterizing RMs and CRMs.
ISO 17034:2016 meets the general requirements for the competence of RM producers. This ISO standard recognizes Cayman for its competence in carrying out the standardized production, storage, and distribution of CRMs.
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Can't find your unknown? Please submit your GC-MS data and any relevant information (suspected chemical class, matrix, solvent, GC parameters, etc.) to email@example.com and our scientists can help you solve your unknown.
Cayman’s Flipbook tool is a user-friendly application designed for forensic chemists to quickly identify drugs of abuse that share common pharmacophores with scheduled substances. Users of the Flipbook tool must be affiliated with federal, state, or local governments or associated with a recognized research institution.
The Cayman Spectral Library is a searchable GC-MS spectral database that contains 70eV EI mass spectral data of hundreds of Cayman Chemical's emerging forensic drug standards. This library is being provided as a free service to assist forensic labs in the identification of emerging synthetic drugs of abuse.
You can download the latest Cayman Spectral Library by acknowledging the disclaimer below. You will be required to login or register. This database is available in two formats:
Cayman makes reasonable efforts to include accurate and up-to-date information, however, we make no representations, warranty or guarantee of any kind, whether written or oral, expressed or implied, including without limitation, any warranty of fitness for a particular purpose, the suitability, merchantability, or to the accuracy or completeness of the information contained herein. All users expressly agree that use of this library is at their sole risk.
Cayman, its officers, directors, employees, agents, suppliers will not be liable for any damages of any kind arising from the use of this library or any information contained herein, including, but not limited to direct, indirect, incidental, punitive and consequential damages.
Many of the new products offered at Cayman are a result of requests from customers like you. A complete list of our qualified forensic drug standards can be found on Forensic Science Products. If you are looking for a currently unavailable forensic standard we encourage you to contact our sales or technical staff with your ideas.
Cayman scientists collaborate with forensic and academic labs to provide data and analytical reference standards to help quickly identify emerging drugs of abuse. With a staff of more than 50 chemists located on a 241,000 ft2 campus in Ann Arbor, Michigan, Cayman has the resources and expertise to offer affordable custom services with reasonable pricing and reliable lead times.
Cayman’s custom mixtures provide an accurate and simplified workflow solution for your mass spectrometry (MS) applications.
Cayman’s analytical team has more than 20 years of experience in analytical chemistry and offers a wide range of services at competitive prices.
Cayman offers custom synthesis of high-purity reference standards at reasonable prices and rapid delivery. Our scientists will work with each customer to confirm emerging drugs of abuse and their metabolites.
To discuss your contract research service needs, please contact us by calling toll free at (888) 526-5351 or by emailing firstname.lastname@example.org. You may also use the form below to provide project information, and a Cayman scientist will contact you.
acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS
Patton, Amy L., Seely, Kathryn A., Pulla, Sharon, Rusch, Nancy J., Moran, Cindy L., Fantegrossi, William E., Knight, Laura D., Marraffa, Jeanna M., Kennedy, Paul D., James, Laura P., Endres, Gregory W., Moran, Jeffery H. Analytical Chemistry. 2014 Feb 4;86(3):1760-6. doi: 10.1021/ac4036197. Epub 2014 Jan 15.
of JWH-018 and JWH-073 Metabolites Excreted in Human Urine
Cindy L. Moran, Vi-Huyen Le, Krishna C. Chimalakonda, Amy L. Smedley, Felisia D. Lackey, Suzanne N. Owen, Paul D. Kennedy, Gregory W. Endres, Fred L. Ciske, James B. Kramer, Andrei M. Kornilov, L. D. Bratton, Paul J. Dobrowolski, William D. Wessinger, William E. Fantegrossi, Paul L. Prather, Laura P. James, Anna Radominska-Pandya, and Jeffery H. Moran, A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors Kathryn A. Seely, Lisa K. Brents, Anna Radominska-Pandya, Gregory W. Endres, Gregory S. Keyes, Jeffery H. Moran, and Paul L. Prather Chem. Res. Toxicol., 2012, 25 (4), pp 825-827
Oxidative Metabolism of Abused Synthetic Cannabinoids Found in "K2/Spice": Identification of
Novel Cannabinoid Receptor Ligands
Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya, Jeffery H. Moran. Drug Metab Dispos. 2012 Nov; 40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17.
Solid-phase extraction and
quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human
Krishna C. Chimalakonda, Cindy L. Moran, Paul D. Kennedy, Gregory W. Endres, Adam Uzieblo, Paul J. Dobrowolski, Kim E. Fifer, Jeff Lapoint, Lewis S. Nelson, Robert S. Hoffman, Laura P. James, Anna Radominska-Pandya, Jeffery H. Moran Anal Chem. Author manuscript; available in PMC 2012 August 15. Published in final edited form as: Anal Chem. 2011 August 15; 83(16): 6381-6388. Published online 2011 July 27. doi: 10.1021/ac201377m
Phase I Hydroxylated
of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
Lisa K. Brents, Emily E. Reichard, Sarah M. Zimmerman, Jeffery H. Moran, William E. Fantegrossi, Paul L. Prather PLoS One. 2011; 6(7): e21917. Published online 2011 July 6. doi: 10.1371/journal.pone.0021917
Conjugation of Synthetic
JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
Krishna C. Chimalakonda, Stacie M. Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L. Moran, Laura P. James, Jeffery H. Moran, Anna Radominska-Pandya Drug Metab Dispos. 2011 October; 39(10): 1967-1976. doi: 10.1124/dmd.111.040709
Forensic investigation of
Spice, and 'bath salt' commercial preparations: a three-year study of new designer drug
containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
Seely KA, Patton AL, Moran CL, Womack ML, Prather PL, Fantegrossi WE, Radominska-Pandya A, Endres GW, Channell KB, Smith NH, McCain KR, James LP, Moran JH. Forensic Sci Int. 2013 Dec 10; 233(1-3): 416-22. doi: 10.1016/j.forsciint.2013.10.002. Epub 2013 Oct 14. Forensic Sci Int. 2013 Dec 10; 233(1-3): 10.1016/j.forsciint.2013.10.002. Epub 2013 Oct 14.
Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
Amy L. Patton, Kathryn A. Seely, Krishna C. Chimalakonda, Johnny P. Tran, Matthew Trass, Art Miranda, William E. Fantegrossi, Paul D. Kennedy, Paul Dobrowolski, Anna Radominska-Pandya, Keith R. McCain, Laura P. James. Anal. Chem. 2013; 6(7)9390–9399. doi: 10.1021/ac4024704. Epud 2013 Aug 29.
A major glucuronidated
metabolite of JWH-018 is a neutral antagonist at CB1 receptors
Seely KA, Brents LK, Radominska-Pandya A, Endres GW, Keyes GS, Moran JH, Prather PL. Chem Res Toxicol. 2012 Apr 16; 25(4): 825-7. doi: 10.1021/tx3000472. Epub 2012 Mar 15.
Quantitation of Synthetic
Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV
Ciolino, Laura A. Journal of Forensic Science. 2015 Sept; 60(5):1171-81.doi:10.1111/1556-4029.12795. Epub 2015 Jul 14.
Cayman’s forensic product line is continually evolving. We are dedicated to working with the forensic and academic communities to identify emerging drugs of abuse and to quickly make authentic reference standards available from our ISO/IEC 17025:2017 and ISO 17034:2016 labs.
Cayman offers parent compounds as well as metabolites, isomers, deuterated standards, and DEA exempt reference standards. Custom mixtures are available upon request.
Certified Reference Materials (CRMs) serve as Primary Standards as defined by ISO and are suitable for labs requiring traceable quantitative standards. A CRM, as defined by ISO 17034:2016, must report the certified concentration and corrected purity values with the corresponding measurement uncertainties. Cayman’s CRMs ensure the metrological traceability and accuracy needed to perform quantitative measurements and are sold as quantitative solutions in sealed ampules.
Cayman’s Reference Materials (RMs) are sold in several sizes allowing for a low-cost, scalable, and highly flexible option for analytical labs. An RM is fully characterized, and its property values are tested under an ISO/IEC 17025:2017 accredited quality system, making it fit for direct use by labs requiring traceable standards.
The Centers for Disease Control and Prevention (CDC) has developed Traceable Opioid Material Kits to support laboratory detection of current and emerging opioids in the U.S. The CDC has contracted Cayman Chemical to manufacture and distribute the FAS Kit, which is part of the Traceable Opioid Material Kits product line. The FAS Kit and its expansion pack (Emergent Panel Version 1) contain analog reference materials that will enable labs to screen for 150 synthetic opioid compounds, including more than 140 fentanyl analogs. To view the entire list of compounds included in the kit, please download the compound list (PDF).
Labs that perform drug testing or analysis may apply for a free FAS Kit if they meet the following requirements:
For additional guidance, contact DEA’s Registration Call Center at 1-800-882-9539 or a local DEA field office. A description of the registration process and a link to DEA’s field office search tool can be found at https://www.deadiversion.usdoj.gov/drugreg/process.htm.
To be considered for a free FAS Kit, please ensure your lab meets the eligibility requirements stated above and completely fill out the application below.