5-OxoETE Receptor Polyclonal Antibody

Item № 100025
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
500 µl $259.00 0.00

Pricing updated 2018-02-25. Prices are subject to change without notice.

Description
Synonyms
  • GPR170
  • OXER1
  • OXER1
  • R527
  • TG1019

5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).1,2 The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.1,2 Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.2 In addition, the protein can also be detected in tissues such as kidney and liver.1,2 Cayman Chemical’s 5-OxoETE receptor polyclonal antibody can be used in western blot analysis (detection at 48 kDa) and immunocytochemistry. The high expression level of the receptor in leukocytes makes it the best positive control sample. When probing other tissue samples such as liver and kidney, membrane preparations or higher sensitivity detection systems may be required for visualization on immunoblot.

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Technical Information
Synonyms
  • GPR170
  • OXER1
  • OXER1
  • R527
  • TG1019
Immunogen
Synthetic peptide from the C-terminal region of human
Formulation
Peptide affinity-purified IgG
Host
rabbit
Applications
ICC and WB
Species Reactivity
  • (+) Human 5-OxoETE receptor
  • (+) Cos-7 (African green monkey) 5-OxoETE receptor
  • (+) Mouse 5-OxoETE receptor
Show all 5
UniProt Accession №
Q8TDS5

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Hosoi, T.,Koguchi, Y.,Sugikawa, E., et al. Identification of a novel human eicosanoid receptor coupled to Gi/o. The Journal of Biological Chemisty 277 (35), 31459-31465 (2002).

2. Jones, C.E.,Holden, S.,Tenaillon, L., et al. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Molecular Pharmacology 63(3), 471-477 (2003).

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