Thromboxane B2 Express ELISA Kit - Monoclonal

Item № 10004023
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
96 solid wells $270.00 0.00
96 strip wells $270.00 0.00
480 solid wells $1,013.00 0.00
480 strip wells $1,013.00 0.00

Pricing updated 2018-02-22. Prices are subject to change without notice.

Description
Features
  • Measure TXB2 in multiple sample types
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Measure TXB2 levels down to 45 pg/ml
  • Rapid assay; get results in under 4 hours
Synonyms
  • TXB2 Express EIA

Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle.1,2,3 TXA2 is rapidly hydrolyzed non-enzymatically to TXB2, which is then quickly metabolized to urinary metabolites for clearance by the kidneys. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis,4 while measurement of 11-dehydro and 2,3-dinor TX metabolites gives the best estimate of systemic TXA2 secretion.5,6 Cayman’s TXB2 Express ELISA is a competitive assay that provides accurate measurements of TXB2 from a variety of sample types. As the name implies, this kit was designed for rapid measurements of TXB2.

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
Synonyms
  • TXB2 Express EIA
Assay Range
15.6-2,000 pg/ml
Sensitivity
80% B/B0: 45 pg/ml
Mid-point
50% B/B0: 150-250 pg/ml
Cross Reactivity
  • (Thromboxane B2) 100%
  • (Thromboxane B3) 10.1%
  • (2,3-dinor Thromboxane B2) 7.9%
Show all 15

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
Product Downloads

Download Kit Booklet

Download Abbreviated Kit Protocol

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Hamberg, M.,Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America 72, 2994-2998 (1975).

2. Ellis, E.F.,Oelz, O.,Roberts, L.J., II, et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193, 1135-1137 (1976).

3. Salzman, P.M.,Salmon, J.A., and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. Journal of Pharmacology and Experimental Therapeutics 215, 240-247 (1980).

4. Patrono, C.,Ciabattoni, G.,Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 11, 493-498 (1983).

5. Lawson, J.A.,Patrono, C.,Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Analytical Biochemistry 155, 198-205 (1986).

6. Patrono, C.,Ciabattoni, G.,Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. Journal of Clinical Investigation 77, 590-594 (1986).

Technical Support

All 480 well kits are supplied with a single 500 dtn vial of antiserum and tracer, or Fab' conjugate that must be used within the stated time following reconstitution.

Analysis Tools

View our analysis workbook for Thromboxane B2 Express ELISA Kit - Monoclonal

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View the pre-configured analysis tool for Thromboxane B2 Express ELISA Kit - Monoclonal on MyAssays.com

Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
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You may be eligible to receive a free sample of Thromboxane B2 Express ELISA Kit - Monoclonal under the Cayman Challenge program.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640