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Item № 10004386
CAS № 38194-50-2
Purity ≥98%
product image
                (CAS 38194-50-2)
     1 g $9.00 0.00
     5 g $41.00 0.00
     10 g $72.00 0.00
     50 g $315.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.1 Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered.2 Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.3

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Technical Information
Formal Name
5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
226, 258, 286, 329 nm
InChI Code
InChI Key
  • Synthetic

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system Biochim Biophys. Acta. 1209(1), 130-139 (1994).

2. Shen, T.Y., and Winter, C.A. Chemical and biological studies on indomethacin, sulindac, and their analogs Advances in Drug Research 12, 89-98 (1977).

3. Boolbol, S.K., Dannenberg, A.J., Chadburn, A., et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis Cancer Research 56, 2556-2560 (1996).

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