CD37 Monoclonal Antibody (Clone IPO-24) | Cayman Chemical
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CD37 Monoclonal Antibody (Clone IPO-24)

Item № 10004718
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 ea $208.00 0.00

Pricing updated 2018-05-27. Prices are subject to change without notice.

Description

CD37 is a type III transmembrane glycoprotein (Mr = 40-52 kDa). The leukocyte-specific protein CD37 is a member of the tetraspanin superfamily, originally described as a cell surface glycoprotein expressed on mature human B cells, but not on pro-B cells or plasma cells.1,2 T cells and monocytes express CD37 at low levels. In humans, CD37 expression is restricted to B and T lymphocytes, monocytes, macrophages, neutrophils, dendritic cells, and certain leukocyte-derived malignant cells. CD37 is not expressed by NK cells, platelets, or erythrocytes.3 CD37 monoclonal antibody is recommended for immunophenotyping of B cell neoplasia (B cell chronic lymphocytic leukemia, hairy cell leukemia, and B cell non-Hodgkin’s lymphomas). Human, rat, and murine CD37 sequences have been identified.4,5

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Technical Information
Clone Designation
IPO-24
Formulation
100 µg of affinity-purified IgG2b in 500 µl PBS, pH 7.2, containing 0.02% sodium azide
Host
mouse
Applications
(+) FC, ICC, and IHC (formalin-fixed paraffin-embedded tissue and frozen sections); (−) WB
Species Reactivity
  • (+) Human CD37

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Maecker, H.T., Todd, S.C., and Levy, S. The tetraspanin superfamily: Molecular facilitators. The FASEB Journal 11, 428-442 (1997).

2. Knobeloch, K.P., Wright, M.D., Ochsenbein, A.F., et al. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Molecular and Cellular Biology 20(15), 5363-5369 (2000).

3. van Spriel, A.B., Puls, K.L., Sofi, M., et al. A regulatory role for CD37 in T cell proliferation. Journal of Immunology 172, 2953-2961 (2004).

4. Tomlinson, M.G., and Wright, M.D. Characterisation of mouse CD37: cDNA and genomic cloning. Molecular Immunology 33(10), 867-872 (1996).

5. Classon, B.J., Williams, A.F., Willis, A.C., et al. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. Journal of Experimental Medicine 169, 1497-1502 (1989).

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