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TOFA

Item № 10005263
CAS № 54857-86-2
Purity ≥98%
product image
                (CAS 54857-86-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $29.00 0.00
     10 mg $55.00 0.00
     50 mg $232.00 0.00
     100 mg $406.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • RMI 14514
  • 5-(Tetradecyloxy)-2-furoic Acid

Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1 TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).2 Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.

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Technical Information
Formal Name
5-(tetradecyloxy)-2-furancarboxylic acid
CAS Number
54857-86-2
Synonyms
  • RMI 14514
  • 5-(Tetradecyloxy)-2-furoic Acid
Molecular Formula
C19H32O4
Formula Weight
324.5
Purity
≥98%
Formulation
A crystalline solid
λmax
278 nm
SMILES
CCCCCCCCCCCCCCOc1ccc(o1)C(=O)O
InChI Code
InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InChI Key
CZRCFAOMWRAFIC-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Moche, M., Schneider, G., Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase The Journal of Biological Chemisty 274(10), 6031-6034 (1999).

2. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288, 2379-2381 (2000).

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