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Fenofibrate

Item № 10005368
CAS № 49562-28-9
Purity ≥98%
product image
                (CAS 49562-28-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 g $9.00 0.00
     5 g $41.00 0.00
     10 g $72.00 0.00
     50 g $315.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.1 It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.2 It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.3 Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.4

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Technical Information
Formal Name
2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester
CAS Number
49562-28-9
Molecular Formula
C20H21ClO4
Formula Weight
360.8
Purity
≥98%
Formulation
A crystalline solid
λmax
287 nm
SMILES
ClC1=CC=C(C(C2=CC=C(OC(C)(C(OC(C)C)=O)C)C=C2)=O)C=C1
InChI Code
InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
InChI Key
YMTINGFKWWXKFG-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery J. Med. Chem. 43(4), 528-550 (2000).

2. Sun, B., Xie, Y., Jiang, J., et al. Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia Lipids Health Dis. 14:27, (2015).

3. Helmy, M.M., Helmy, M.W., and El-Mas, M.M. Additive renoprotection by pioglitazone and fenofibrate against inflammatory, oxidative and apoptotic manifestations of cisplatin nephrotoxicity: Modulation by PPARs PLoS One 10(11), e0142303 (2015).

4. Kuno, T., Hata, K., Takamatsu, M., et al. The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice Int. J. Mol. Sci. 15(5), 9160-9172 (2014).

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