Pricing updated 2019-07-17. Prices are subject to change without notice.
A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FASN). Inhibition of FASN by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines,1 an effect believed to be mediated by the accumulation of malonyl-
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Moche, M., Schneider, G., Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-
Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-
3. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288, 2379-2381 (2000).