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Hesperetin

Item № 10006084
CAS № 520-33-2
Purity ≥98%
product image
                (CAS 520-33-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     25 g $38.00 0.00
     50 g $72.00 0.00
     100 g $137.00 0.00
     500 g $570.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

The flavones and flavonoids are a widespread group of natural products with a variety of reported beneficial health effects. Flavonoids have been implicated as possible active agents in the dietary benefits of citrus fruits. Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in HepG2 cells and reduces ApoB protein synthesis in a dose-dependent manner. The EC50 for these responses is approximately 50 µM.1 Hesperetin also inhibits histamine release from IgE-challenged RBL-2H3 cells, with a potency comparable to the commercial anti-allergy drug azelastine.2

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Technical Information
Formal Name
2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
520-33-2
Molecular Formula
C16H14O6
Formula Weight
302.3
Purity
≥98%
Formulation
A crystalline solid
λmax
204, 288 nm
SMILES
COc1ccc(cc1O)C1CC(=O)c2c(cc(O)cc2O)O1
InChI Code
InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
InChI Key
AIONOLUJZLIMTK-AWEZNQCLSA-N
Origin
  • Plant/Citrus sinensis;Citrus limon

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Wilcox, L.J., Borradaile, N.M., de Dreu, L.E., et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP Journal of Lipid Research 42, 725-734 (2001).

2. Lee, N.K., Choi, S.H., Park, S.H., et al. Antiallergic activity of hesperidin is activated by intestinal microflora Pharmacology 71, 174-180 (2004).

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