We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

GW 4064

Item № 10006611
CAS № 278779-30-9
Purity ≥95%
product image
                (CAS 278779-30-9)
     1 mg $25.00 0.00
     5 mg $69.00 0.00
     10 mg $108.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity.1 GW 4064 is a selective agonist of FXR (EC50 = 15 nM).2 It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM.2 GW 4064 is used to elucidate the role of FXR in dyslipidemia, diabetes, obesity, and cancer.3,4,5,6,7

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic acid
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
304 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Rader, D.J. Liver X receptor and farnesoid X receptor as therapeutic targets American Journal of Cardiology 100, 15N-19N (2007).

2. Maloney, P.R., Parks, D.J., Haffner, C.D., et al. Identification of a chemical tool for the orphan nuclear receptor FXR Journal of Medicinal Chemistry 43(16), 2971-2974 (2000).

3. Haeusler, R.A., Pratt-Hyatt, M., Welch, C.L., et al. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia Cell Metabolism 15(1), 65-74 (2012).

4. Watanabe, M., Horai, Y., Houten, S.M., et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure The Journal of Biological Chemisty 286(30), 26913-26920 (2011).

5. Deuschle, U., Schüler, J., Schulz, A., et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model PLoS One 7(10), e43044 (2012).

6. Catalano, S., Malvindi, R., Giordano, C., et al. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells The Journal of Biological Chemisty 285(8), 5581-5593 (2010).

7. Cariou, B., van Harmelen, K., Duran-Sandoval, D., et al. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice The Journal of Biological Chemisty 281(16), 11039-11049 (2006).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640