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PD 98059

Item № 10006726
CAS № 167869-21-8
Purity ≥98%
product image
                (CAS 167869-21-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $12.00 0.00
     5 mg $45.00 0.00
     10 mg $65.00 0.00
     50 mg $260.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • NSC 679828

PD 98059 is a noncompetitive inhibitor of the MAPK pathway.1,2 It prevents the activation of MEK by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1.3 It inhibits Raf activation of MAPKK2 with an IC50 value of 50 µM.3 PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).4 It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

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Technical Information
Formal Name
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
167869-21-8
Synonyms
  • NSC 679828
Molecular Formula
C16H13NO3
Formula Weight
267.3
Purity
≥98%
Formulation
A crystalline solid
λmax
239, 300, 375 nm
SMILES
COc1cccc(c2cc(=O)c3ccccc3o2)c1N
InChI Code
InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI Key
QFWCYNPOPKQOKV-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351(1), 95-105 (2000).

2. Dudley, D.T., Pang, L., Decker, S.J., et al. A synthetic inhibitor of the mitogen-activated protein kinase cascade Proc. Natl. Acad. Sci. U.S.A. 92(17), 7686-7689 (1995).

3. Alessi, D.R., Cuenda, A., Cohen, P., et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo J. Biol. Chem. 270(46), 27489-27494 (1995).

4. Dokladda, K., Green, K.A., Pan, D.A., et al. PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway FEBS Lett. 579(1), 236-240 (2005).

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