Pricing updated 2019-07-17. Prices are subject to change without notice.
PD 98059 is a noncompetitive inhibitor of the MAPK pathway.1,2 It prevents the activation of MEK by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1.3 It inhibits Raf activation of MAPKK2 with an IC50 value of 50 µM.3 PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).4 It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
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1. Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351(1), 95-105 (2000).
Dudley, D.T., Pang, L., Decker, S.J., et al. A synthetic inhibitor of the mitogen-
Alessi, D.R., Cuenda, A., Cohen, P., et al. PD 098059 is a specific inhibitor of the activation of mitogen-
Dokladda, K., Green, K.A., Pan, D.A., et al. PD98059 and U0126 activate AMP-