GW 0742 (CAS 317318-84-6) | Cayman Chemical
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GW 0742

Item № 10006798
CAS № 317318-84-6
Purity ≥95%
product image
                (CAS 317318-84-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $65.00 0.00
     10 mg $124.00 0.00
     25 mg $293.00 0.00
     50 mg $455.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

Description

The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

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Technical Information
Formal Name
[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid
CAS Number
317318-84-6
Molecular Formula
C21H17F4NO3S2
Formula Weight
471.5
Purity
≥95%
Formulation
A crystalline solid
λmax
226, 323 nm
SMILES
CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C(F)=C3)S2)=CC=C1OCC(O)=O
InChI Code
InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
InChI Key
HWVNEWGKWRGSRK-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity Bioorganic & Medicinal Chemistry Letters 13, 1517-1521 (2003).

2. Smith, S.A., Monteith, G.R., Robinson, J.A., et al. Effect of the peroxisome proliferator-activated receptorβ activator GW0742 in rat cultured cerebellar granule neurons Journal of Neuroscience Research 77, 240-249 (2004).

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