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10-Thiastearic Acid

Item № 10007417
CAS № 105099-89-6
Purity ≥98%
product image
                (CAS 105099-89-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $33.00 0.00
     10 mg $63.00 0.00
     50 mg $264.00 0.00
     100 mg $462.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.1,2 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.3 This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

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Technical Information
Formal Name
9-(octylthio)-nonanoic acid
CAS Number
105099-89-6
Molecular Formula
C17H34O2S
Formula Weight
302.5
Purity
≥98%
Formulation
A crystalline solid
SMILES
CCCCCCCCSCCCCCCCCC(O)=O
InChI Code
InChI=1S/C17H34O2S/c1-2-3-4-5-9-12-15-20-16-13-10-7-6-8-11-14-17(18)19/h2-16H2,1H3,(H,18,19)
InChI Key
OMIBNTWPNMKIGZ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids Biochemical Pharmacology 51, 751-758 (1996).

2. Pascal, R.A., Jr., and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid Journal of Lipid Research 27, 221-224 (1986).

3. Hovik, K.E., Spydevold, O.S., and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase Biochimica et Biophysica Acta 1349, 251-256 (1997).

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