We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Pargyline (hydrochloride)

Item № 10007852
CAS № 306-07-0
Purity >98%
product image
                (CAS 306-07-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 mg $6.00 0.00
     500 mg $27.00 0.00
     1 g $48.00 0.00
     5 g $210.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • NSC 43798

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).1 At 10 mg/kg i.v., pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats.2 The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.3 Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.4 Formulations containing pargyline have been used to treat moderate hypertension.4,5

Recommended Products

Related Products
View Related Product Categories
View Screening Libraries with Pargyline (hydrochloride)
Technical Information
Formal Name
N-methyl-N-2-propyn-1-yl-benzenemethanamine, monohydrochloride
CAS Number
306-07-0
Synonyms
  • NSC 43798
Molecular Formula
C11H13N • HCl
Formula Weight
195.7
Purity
>98%
Formulation
A crystalline solid
SMILES
CN(CC#C)CC1=CC=CC=C1.Cl
InChI Code
InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
InChI Key
BCXCABRDBBWWGY-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Fowler, C.J., Mantle, T.J., and Tipton, K.F. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline Biochem. Pharmacol. 31(22), 3555-3561 (1982).

2. Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats Eur. J. Pharmacol. 57(1), 21-27 (1979).

3. Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats J. Pharm. Pharmacol. 24(9), 690-695 (1972).

4. Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation FASEB J. 19(6), 641-643 (2005).

5. Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA J. Pharmacol. Exp. Ther. 182(1), 130-134 (1972).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640