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Pargyline (hydrochloride)

Item № 10007852
CAS № 306-07-0
Purity >98%
product image
                (CAS 306-07-0)
     100 mg $6.00 0.00
     500 mg $27.00 0.00
     1 g $48.00 0.00
     5 g $210.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

  • NSC 43798

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).1 At 10 mg/kg i.v., pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats.2 The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.3 Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.4 Formulations containing pargyline have been used to treat moderate hypertension.4,5

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Technical Information
Formal Name
N-methyl-N-2-propyn-1-yl-benzenemethanamine, monohydrochloride
CAS Number
  • NSC 43798
Molecular Formula
C11H13N • HCl
Formula Weight
A crystalline solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Fowler, C.J., Mantle, T.J., and Tipton, K.F. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline Biochem. Pharmacol. 31(22), 3555-3561 (1982).

2. Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats Eur. J. Pharmacol. 57(1), 21-27 (1979).

3. Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats J. Pharm. Pharmacol. 24(9), 690-695 (1972).

4. Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation FASEB J. 19(6), 641-643 (2005).

5. Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA J. Pharmacol. Exp. Ther. 182(1), 130-134 (1972).

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