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Gabapentin

Item № 10008346
CAS № 60142-96-3
Purity ≥98%
product image
                (CAS 60142-96-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     10 mg $30.00 0.00
     25 mg $71.00 0.00
     50 mg $135.00 0.00
     100 mg $240.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • CI-945​

γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord.1 Gabapentin is a γ-aminobutyric acid (GABA) analogue that acts as an anticonvulsant with proven analgesic effects in various neuropathic pain syndromes such as Complex Regional Pain Syndrome type one (CRPS 1).2,3,4 It is also prescribed to multiple sclerosis patients to control dysesthesias and may be useful in reducing neuropathic pain caused by cancer and HIV infection. It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase.5,6 Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α2δ-type voltage-gated calcium channels. The mechanism for the analgesic and anticonvulsant effects of gabapentin are not known.2,3,4,5,6

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Technical Information
Formal Name
1-(aminomethyl)-cyclohexaneacetic acid
CAS Number
60142-96-3
Synonyms
  • CI-945​
Molecular Formula
C9H17NO2
Formula Weight
171.2
Purity
≥98%
Formulation
A crystalline solid
SMILES
NCC1(CCCCC1)CC(=O)O
InChI Code
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChI Key
UGJMXCAKCUNAIE-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Malcangio, M., and Bowery, N.G. GABA and its receptors in the spinal cord Trends in Pharamacological Sciences 17, 457-462 (1996).

2. van de Vusse, A.C., Stonmp-van de Berg, S.G.M., Kessels, A.H.F., et al. Randomised controlled trial of gabapentin in complex regional pain syndrome type I [ISRCTN84121379] BMC Neurol. 4(13), (2004).

3. Hahn, K., Arendt, G., Braun, J.S., et al. A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies J. Neurol. 251(10), 1260-1266 (2004).

4. Caraceni, A., Zecca, E., Bonezzi, C., et al. Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study group J. Clin. Oncol. 22(14), 2909-2917 (2004).

5. Gee, N.S., Brown, J.P., Dissanayake, V.U.K., et al. The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel J. Biol. Chem. 271(10), 5768-5776 (1996).

6. Goa, K.L., and Sorkin, E.M. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy Drugs 46(3), 409-427 (1993).

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