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γ-Tocotrienol

Item № 10008494
CAS № 14101-61-2
Purity ≥98%
product image
                (CAS 14101-61-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $21.00 0.00
     5 mg $95.00 0.00
     10 mg $168.00 0.00
     25 mg $368.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.1 Tocotrienols are found in high concentrations in palm oil and rice bran. Recent studies observe that tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.2 Spontaneously hypertensive rats fed a diet which includes γ-tocotrienol show significant reduction of systolic blood pressure and an increase of nitric oxide synthase activity in blood vessels.3 γ-Tocotrienol at 20 µM induces apoptosis of malignant sympathoadrenal (+SA) murine mammary epithelial cells.4

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Technical Information
Formal Name
3,4-dihydro-2,7,8-trimethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol
CAS Number
14101-61-2
Molecular Formula
C28H42O2
Formula Weight
410.6
Purity
≥98%
Formulation
A solution in ethanol
λmax
297 nm
SMILES
C[C@]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C(C)=C(O)C=C2CC1
InChI Code
InChI=1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1
InChI Key
OTXNTMVVOOBZCV-WAZJVIJMSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Kamal-Eldin, A., and Appelqvist, L.Å. The chemistry and antioxidant properties of tocopherols and tocotrienols Lipids 31, 671-701 (1996).

2. Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons Neuropharmacology 47, 904-915 (2004).

3. Shah, S., and Sylvester, P.W. Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells Experimental Biology and Medicine 229, 745-755 (2004).

4. Newaz, M.A., Yousefipour, Z., Nawal, N., et al. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: Antioxidant protection by γ-tocotrienol Journal of Physiology and Pharmacology 54(3), 319-327 (2003).

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