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GW 7647

Item № 10008613
CAS № 265129-71-3
Purity ≥98%
product image
                (CAS 265129-71-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $28.00 0.00
     5 mg $112.00 0.00
     10 mg $168.00 0.00
     25 mg $315.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 GW 7647 is a potent, selective agonist of human and murine PPARα4 It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.4

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Technical Information
Formal Name
2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methyl-propanoic acid
CAS Number
265129-71-3
Molecular Formula
C29H46N2O3S
Formula Weight
502.8
Purity
≥98%
Formulation
A crystalline solid
λmax
230 nm
SMILES
O=C(NC1CCCCC1)N(CCCCC1CCCCC1)CCc1ccc(cc1)SC(C)(C)C(=O)O
InChI Code
InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
InChI Key
PKNYXWMTHFMHKD-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism Biochimie 79, 81-94 (1997).

2. Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology Annual Reviews of Cell Development and Biology 12, 335-363 (1996).

3. Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes Cellular and Molecular Life Sciences 61, 393-416 (2004).

4. Brown, P.J., Stuart, L.W., Hurley, K.P., et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis Bioorganic & Medicinal Chemistry Letters 11, 1225-1227 (2001).

Product Citations

Baumgartner, L., Sosa, S., Atanasov, A.G., et al. Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro J. Nat. Prod. 74(8), 1779-1786 (2011).

Aleshin, S., Grabeklis, S., Hanck, T., et al. Peroxisome proliferator-activated receptor (PPAR)-g positively controls and PPARa negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARb/d via mutual control of PPAR expression levels Mol. Pharmacol. 76(2), 414-424 (2009).

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