A selective PPARα agonist
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GW 7647

Item No. 10008613

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methyl-propanoic acid
CAS Number
265129-71-3
Molecular Formula
C29H46N2O3S
Formula Weight
502.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 15 mg/ml
λmax
230 nm
SMILES
O=C(NC1CCCCC1)N(CCCCC1CCCCC1)CCc1ccc(cc1)SC(C)(C)C(=O)O
InChi Code
InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
InChi Key
PKNYXWMTHFMHKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    10 mg

    $235

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    25 mg

    $437

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    GW 7647 is a potent, selective agonist of human and murine PPARα1 It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, P.J., Stuart, L.W., Hurley, K.P., et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg. Med. Chem. Lett. 11, 1225-1227 (2001).

    Product Citations

    Tiefenbach, J., Magomedova, L., Liu, J., et al. Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases. Dis. Model Mech. 11(9), (2018).

    Baumgartner, L., Sosa, S., Atanasov, A.G., et al. Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J. Nat. Prod. 74(8), 1779-1786 (2011).

    Aleshin, S., Grabeklis, S., Hanck, T., et al. Peroxisome proliferator-activated receptor (PPAR)-g positively controls and PPARa negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARb/d via mutual control of PPAR expression levels. Mol. Pharmacol. 76(2), 414-424 (2009).