N-Octadecyl-N'-propyl-sulfamide

Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.^1,2 N-Octadecyl-N'-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC₅₀ value of 100 nM, compared to OEA, which exhibits an EC₅₀ value of 120 nM.^3,2 At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N'-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.³

WARNING This product is not for human or veterinary use.

1. de Fonseca, F.R., Navarro, M., Gómez, R., et al. An anorexic lipid mediator regulated by feeding. Nature 414(6860), 209-212 (2001).

2. Fu, J., Gaetani, S., Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425(6953), 90-93 (2003).

3. Cano, C., Pavón, J., Serrano, A., et al. Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARα activation. J. Med. Chem. 50(2), 389-393 (2007).