LY293111 (CAS 161172-51-6) | Cayman Chemical
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LY293111

Item № 10009768
CAS № 161172-51-6
Purity ≥98%
product image
                (CAS 161172-51-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $86.00 0.00
     1 mg $163.00 0.00
     5 mg $688.00 0.00
     10 mg $1,204.00 0.00

Pricing updated 2018-11-14. Prices are subject to change without notice.

Description
Synonyms
  • Etalocib
  • VML 295

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. LY293111 is a potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 17.6 nM and inhibits the LTB4-induced chemotaxis of human neutrophils with an IC50 value of 6.3 nM.1 LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 human pancreatic cancer cells in vitro (250-1,000 nM) and subcutaneous xenografts in athymic mice (250 mg/kg/day), inducing apoptosis and S-phase arrest.2

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Technical Information
Formal Name
2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid
CAS Number
161172-51-6
Synonyms
  • Etalocib
  • VML 295
Molecular Formula
C33H33FO6
Formula Weight
544.6
Purity
≥98%
Formulation
A solution in methyl acetate
λmax
205, 256, 294 nm
SMILES
CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(F)cc2)cccc1Oc1ccccc1C(=O)O
InChI Code
InChI=1S/C33H33FO6/c1-3-9-25-29(12-7-13-30(25)40-31-11-6-5-10-26(31)33(36)37)38-18-8-19-39-32-21-28(35)27(20-22(32)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
InChI Key
YFIZRWPXUYFCSN-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Jackson, W.T., Froelich, L.L., Boyd, R.J., et al. Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: In vitro studies Journal of Pharmacology and Experimental Therapeutics 288(1), 286-294 (1999).

2. Tong, W.G., Ding, X.Z., Hennig, R., et al. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells Clinical Cancer Research 8, 3232-3242 (2002).

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