Farnesyl Thiosalicylic Acid (CAS 162520-00-5) | Cayman Chemical
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Farnesyl Thiosalicylic Acid

Item № 10010501
CAS № 162520-00-5
Purity ≥96%
product image
                (CAS 162520-00-5)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $32.00 0.00
     10 mg $58.00 0.00
     25 mg $136.00 0.00
     50 mg $256.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

Description
Synonyms
  • FTS
  • Salirasib

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation.1 FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 µM.2 It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a Ki value of 2.6 µM, it is relatively ineffective at inhibiting methylation in whole cells.3 Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.4

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Technical Information
Formal Name
2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzoic acid
CAS Number
162520-00-5
Synonyms
  • FTS
  • Salirasib
Molecular Formula
C22H30O2S
Formula Weight
358.5
Purity
≥96%
Formulation
A crystalline solid
λmax
263, 321 nm
SMILES
C/C(=C\CSc1ccccc1C(=O)O)/CC/C=C(\C)/CCC=C(C)C
InChI Code
InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+
InChI Key
WUILNKCFCLNXOK-CFBAGHHKSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Haklai, R., Weisz, M.G., Elad, G., et al. Dislodgment and accelerated degradation of ras Biochemistry 37, 1306-1314 (1998).

2. Marciano, D., Ben-Baruch, G., Marom, M., et al. Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth Journal of Medicinal Chemistry 38, 1267-1272 (1995).

3. Marom, M., Haklai, R., Ben-Baruch, G., et al. Selective inhibition of ras-dependent cell growth by farnesylthiosalicylic acid The Journal of Biological Chemisty 270(38), 22263-22270 (1995).

4. George, J., Afek, A., Keren, P., et al. Functional inhibition of ras by S-trans, trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice Circulation 105, 2416-2422 (2002).

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