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CAY10566

Item № 10012562
CAS № 944808-88-2
Purity ≥98%
product image
                (CAS 944808-88-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $65.00 0.00
     5 mg $276.00 0.00
     10 mg $488.00 0.00
     25 mg $975.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation.1,2,3 Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.4 This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC50 values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.4

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Technical Information
Formal Name
3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine
CAS Number
944808-88-2
Molecular Formula
C18H17ClFN5O2
Formula Weight
389.8
Purity
≥98%
Formulation
A crystalline solid
SMILES
Cc1nnc(o1)c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl
InChI Code
InChI=1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3
InChI Key
WFOFPVXMPTVOTJ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Cohen, P., Miyazaki, M., Socci, N.D., et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss Science 297, 240-243 (2002).

2. Dobrzyn, P., Sampath, H., Dobrzyn, A., et al. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart American Journal of Physiology.Endocrinology and Metabolism 294, E357-E364 (2008).

3. Miyazaki, M., Flowers, M.T., Sampath, H., et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis Cell Metabolism 6, 484-496 (2007).

4. Liu, G., Lynch, J.K., Freeman, J., et al. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors Journal of Medicinal Chemistry 50, 3086-3100 (2007).

Product Citations

Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state Cell Chem. Biol. 26(3), 420-432 (2019).

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