Pricing updated 2019-06-19. Prices are subject to change without notice.
URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme that hydrolyzes anandamide (AEA; Item No. 90050) and other simple esters and amides with long unsaturated acyl chains (IC50 = 4.6 nM and 0.5 nM in brain membranes and intact neurons, respectively).1,2 URB597 exhibits both antinociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds. This antinociceptive effect is similar to those observed in FAAH(-/-) mice.3
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1. Kathuria, S., Gaetani, S., Fegley, D., et al. Modulation of anxiety through blockade of anandamide hydrolysis Nature Medicine 1(9), 76-81 (2003).
Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-
3. Cravatt, B.F., Demarest, K., Patricelli, M.P., et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Proceedings of the National Academy of Sciences of the United States of America 98(16), 9371-9376 (2001).
Soethoudt, M., Grether, U., Fingerle, J., et al. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-