Pricing updated 2019-07-23. Prices are subject to change without notice.
Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila and has diverse biological activities, including anticancer, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, and cardioprotective properties.1,2,3,4 It inhibits the proliferation of HepG2 liver, MCF-7 breast, and Caco-2 colon cancer cells (EC50s = 87.4, 14.4, and 34.4 μM, respectively).2 Ursolic acid reverses increases in hepatic steatosis, levels of hepatic triglycerides and free fatty acids, and hepatic TNF-α, IL-1β, IL-6, and IL-8 mRNA expression in a dose-dependent manner in a high-fat diet-induced rat model of non-alcoholic fatty liver disease (NAFLD).4 Ursolic acid also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 59.7 μg/ml) and inhibits the growth of several strains of Gram-positive and Gram-negative bacteria in vitro including S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and S. flexneri (MICs = 32-512 μg/ml).3
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Woźniak, Ł., Skąpska, S., and Marszałek, K. Ursolic acid--
2. He, X., and Liu, R.H. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity Journal of Agricultural and Food Chemistry 55, 4366-4370 (2007).
3. do Nascimento, P.G.G., Lemos, T.L.G., Bizerra, A.M.C., et al. Antibacterial and antioxidant activities of ursolic acid and derivatives Molecules 19(1), 1317-1327 (2014).
Li, S., Meng, F., Liao, X., et al. Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-