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N-Oleoyl Dopamine

Item № 10115
CAS № 105955-11-1
Purity ≥98%
product image
                (CAS 105955-11-1)
     5 mg $35.00 0.00
     10 mg $67.00 0.00
     50 mg $280.00 0.00
     100 mg $490.00 0.00

Pricing updated 2019-03-21. Prices are subject to change without notice.

  • ODA

N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.1 Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.1 It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.2,3

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Technical Information
Formal Name
CAS Number
  • ODA
Molecular Formula
Formula Weight
A crystalline solid
220, 283 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Chu, C.J., Huang, S.M., De Petrocellis, L., et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia The Journal of Biological Chemisty 278(16), 13633-13639 (2003).

2. Tseng, C.F., Iwakami, S., Mikajiri, A., et al. Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-β-phenethylamine and N-acyldopamine derivatives Chemical & Pharmaceutical Bulletin 40(2), 396-400 (1992).

3. Iwakami, S., Shibuya, M., Tseng, C.F., et al. Inhibition of arachidonate 5-lipoxygenase by phenolic compounds Chemical & Pharmaceutical Bulletin 34, 3960-3963 (1986).

Product Citations

Matsumoto, G., Inobe, T., Amano, T., et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression Sci. Rep. 8(1), 9585 (2018).

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