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3,4-Methylenedioxy Pyrovalerone (hydrochloride)

Item № 10684
CAS № 24622-62-6
Purity ≥98%

Formulation:  A crystalline solid

SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $65.00 0.00
     10 mg $117.00 0.00
     50 mg $439.00 0.00

Pricing updated 2019-03-26. Prices are subject to change without notice.

Description
Synonyms
  • 3,4-MDPV

Pyrovalerone (Item No. 10817) and its analogs are inhibitors of the transporters for certain monoamine neurotransmitters, including dopamine and norepinephrine, preventing their uptake.1,2 3,4-Methylenedioxy Pyrovalerone (3,4-MDPV) is an analog of pyrovalerone which includes the 3,4-methylenedioxy moiety found on 3,4-methylenedioxymethamphetamine, a DEA Schedule I controlled substance. While its physiological, neurological, and toxicological actions have not been characterized, 3,4-MDPV has been reported by the DEA to be abused as a central nervous system stimulant.3 Its effective dose and chemical interactions are unknown, but it has been used alone and in combination with other stimulating compounds. Products containing 3,4-MDPV have been marketed in Europe and Australia; they have also been seized by law enforcement in several states.3 3,4-MDPV and some of its metabolites have recently been characterized by spectroscopic analysis.4,5,6,7 3,4-MDPV is to be used in the forensic analysis of samples that may contain this compound. This product, the hydrochloride salt of 3,4-MDPV, has superior solubility in aqueous solvents, compared to the free base (Item No. 10624).

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Technical Information
Formal Name
1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone, monohydrochloride
CAS Number
24622-62-6
Synonyms
  • 3,4-MDPV
Molecular Formula
C16H21NO3 • HCl
Formula Weight
311.8
Purity
≥98%
Formulation
A crystalline solid
λmax
234, 281, 318 nm
SMILES
O=C(C1=CC(OCO2)=C2C=C1)C(CCC)N3CCCC3.Cl
InChI Code
InChI=1S/C16H21NO3.ClH/c1-2-5-13(17-8-3-4-9-17)16(18)12-6-7-14-15(10-12)20-11-19-14;/h6-7,10,13H,2-5,8-9,11H2,1H3;1H
InChI Key
PYQZNWFQAMFAMT-UHFFFAOYSA-N
Schedule
I

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Heron, C., Costentin, J., and Bonnet, J.J. Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier Eur. J. Pharmacol. 264(3), 391-398 (1994).

2. Meltzer, P.C., Butler, D., Deschamps, J.R., et al. 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogs. A promising class of monoamine uptake inhibitors J. Med. Chem. 49(4), 1420-1432 (2006).

3. Drug Enforcement Admin.Office of Diversion, C. Methylenedioxypyrovalerone [(MDPV) 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone] .

4. Westphal, F., Junge, T., Rosner, P., et al. Mass and NMR spectroscopic characterization of 3,4-methylenedioxypyrovalerone: A designer drug with α-pyrrolidinophenone structure Forensic Science International 190, 1-8 (2009).

5. Meyer, M.R., Du, P., Schuster, F., et al. Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS Journal of Mass Spectrometry 45(12), 1426-1442 (2010).

6. Yohannan, J.C., and Bozenko, J.S. The characterization of 3,4-methylenedioxypyrovalerone (MDPV) Microgram Journal 7 (1), 12-15 (2010).

7. Strano-Rossi, S., Cadwallader, A.B., de la Torre, X., et al. Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry Rapid Communications in Mass Spectrometry 24, 2706-2714 (2010).

Product Citations

Tremeau-Cayel, L., Carnes, S., Schandield, M.S., et al. A comparison of single quadrupole mass detection and diode array ultraviolet detection interfaced to ultra-high performance supercritical chromatography for the quantitative analysis of synthetic cathinones J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1091, 96-100 (2018).

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