Pricing updated 2019-07-17. Prices are subject to change without notice.
Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).1,2,3,4 By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes.2 Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ‘exenatide.’ Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.5,6 Exenatide also has anxiolytic and anti-depressant effects and induces satiety.6,7
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Eng, J., Kleinman, W.A., Singh, L., et al. Isolation and characterization of exendin-
Göke, R., Fehmann, H.C., Linn, T., et al. Exendin-
Thorens, B., Porret, A., Bühler, L., et al. Cloning and functional expression of the human islet GLP-
Donnelly, D. The structure and function of the glucagon-
Perry, T., Haughey, N.J., Mattson, M.P., et al. Protection and reversal of excitotoxic neuronal damage by glucagon-
Komsuoglu Celikyurt, I., Mutlu, O., Ulak, G., et al. Exenatide treatment exerts anxiolytic-
van Bloemendaal, L., Ten Kulve, J.S., la Fleur, S.E., et al. Effects of glucagon-