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Item № 11151
CAS № 4098-40-2
Purity ≥95%
product image
                (CAS 4098-40-2)

Formulation:  A neat solid

     1 mg $65.00 0.00
     5 mg $292.00 0.00

Pricing updated 2019-03-26. Prices are subject to change without notice.

  • This product has been manufactured and tested to meet ISO17025:2005 and Guide 34:2009 guidelines
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
  • 9-methoxy Corynantheidine

Mitragynine is an indole alkaloid from the plant M. speciosa. It has stimulatory, antinociceptive, and opiate-like effects, acting through noradrenergic, serotonergic, and opioid receptors.1,2 Mitragynine has a higher affinity for the μ-opioid receptor than the δ- or κ-opioid receptors (pKi = 8.14, 7.22, and 5.96, respectively).2 Mitragynine and its derivatives have been identified in products sold as incense.3 The identification and quantification of mitragynine and related alkaloids, as well as their phase I and II metabolites, have been described.4,5,6 This product is intended for forensic applications.

This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.

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Technical Information
Formal Name
(αE,2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
CAS Number
  • 9-methoxy Corynantheidine
Molecular Formula
Formula Weight
A neat solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 1 year
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References & Product Citations
Product Description References

1. Matsumoto, K., Mizowaki, M., Suchitra, T., et al. Central antinociceptive effects of mitragynine in mice: Contribution of descending noradrenergic and serotonergic systems Eur. J. Pharmacol. 317(1), 75-81 (1996).

2. Takayama, H., Ishikawa, H., Kurihara, M., et al. Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands J. Med. Chem. 45(9), 1949-1956 (2002).

3. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3), 109-115 (2011).

4. Lu, S., Tran, B.N., Nelsen, J.L., et al. Quantitative analysis of mitragynine in human urine by high performance liquid chromatography-tandem mass spectrometry Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences 877(24), 2499-2505 (2009).

5. Philipp, A.A., Wissenbach, D.K., Weber, A.A., et al. Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography- linear ion trap- mass spectrometry Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences 879(15-16), 1049-1055 (2011).

6. Chittrakarn, S., Penjamras, P., and Keawpradub, N. Quantitative analysis of mitragynine, codeine, caffeine, chlorpheniramine and phenylephrine in a kratom (Mitragyna speciosa Korth.) cocktail using high-performance liquid chromatography Forensic Sci. Int. 217(1-3), 81-83 (2011).

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