Pricing updated 2019-04-23. Prices are subject to change without notice.
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-
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1. Filippakopoulos, P., Qi, J., Picaud, S., et al. Selective inhibition of BET bromodomains Nature 468(7327), 1067-1073 (2010).
2. Dawson, M.A., Kouzarides, T., and Huntly, B.J. Targeting epigenetic readers in cancer N. Engl. J. Med. 367(7), 647-657 (2012).
Delmore, J.E., Issa, G.C., Lemieux, M.E., et al. BET bromodomain inhibition as a therapeutic strategy to target c-
4. Mertz, J.A., Conery, A.R., Bryant, B.M., et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains Proc. Natl. Acad. Sci. USA 108(40), 16669-16674 (2011).
Dawson, M.A., Prinjha, R.K., Dittmann, A., et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-